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Risk-related short-term clinical outcomes after transcatheter aortic valve implantation and their impact on early mortality: an analysis of claims-based data from Germany

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Risk-related short-term clinical outcomes after transcatheter aortic valve implantation and their impact on early mortality: an analysis of claims-based data from Germany. / Schofer, Niklas; Jeschke, Elke; Kröger, Janine; Baberg, Henning; Falk, Volkmar; Gummert, Jan F; Hamm, Christian W; Möckel, Martin; Goßling, Alina; Malzahn, Jürgen; Günster, Christian; Blankenberg, Stefan.

In: CLIN RES CARDIOL, Vol. 111, No. 8, 08.2022, p. 934-943.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schofer, N, Jeschke, E, Kröger, J, Baberg, H, Falk, V, Gummert, JF, Hamm, CW, Möckel, M, Goßling, A, Malzahn, J, Günster, C & Blankenberg, S 2022, 'Risk-related short-term clinical outcomes after transcatheter aortic valve implantation and their impact on early mortality: an analysis of claims-based data from Germany', CLIN RES CARDIOL, vol. 111, no. 8, pp. 934-943. https://doi.org/10.1007/s00392-022-02009-y

APA

Schofer, N., Jeschke, E., Kröger, J., Baberg, H., Falk, V., Gummert, J. F., Hamm, C. W., Möckel, M., Goßling, A., Malzahn, J., Günster, C., & Blankenberg, S. (2022). Risk-related short-term clinical outcomes after transcatheter aortic valve implantation and their impact on early mortality: an analysis of claims-based data from Germany. CLIN RES CARDIOL, 111(8), 934-943. https://doi.org/10.1007/s00392-022-02009-y

Vancouver

Schofer N, Jeschke E, Kröger J, Baberg H, Falk V, Gummert JF et al. Risk-related short-term clinical outcomes after transcatheter aortic valve implantation and their impact on early mortality: an analysis of claims-based data from Germany. CLIN RES CARDIOL. 2022 Aug;111(8):934-943. https://doi.org/10.1007/s00392-022-02009-y

Bibtex

@article{d76cb5c9a4b24dc19ed1b85dd9a79821,
title = "Risk-related short-term clinical outcomes after transcatheter aortic valve implantation and their impact on early mortality: an analysis of claims-based data from Germany",
abstract = "OBJECTIVES: We aimed to define and assess risk-specific adverse outcomes after transcatheter aortic valve implantation (TAVI) in an all-comers patient population based on German administrative claims data.METHODS: Administrative claims data of patients undergoing transvascular TAVI between 2017 and 2019 derived from the largest provider of statutory health-care insurance in Germany were used. Patients' risk profile was assessed using the established Hospital Frailty Risk (HFR) score and 30-day adverse events were evaluated. Multivariable logistic regression models were applied to investigate the relation of patients' risk factors to clinical outcomes and, subsequently, of clinical outcomes to mortality.RESULTS: A total of 21,430 patients were included in the analysis. Of those, 51% were categorized as low-, 37% as intermediate-, and 12% as high-risk TAVI patients according to HFR score. Whereas low-risk TAVI patients showed low rates of periprocedural adverse events, TAVI patients at intermediate or high risk suffered from worse outcomes. An increase in HFR score was associated with an increased risk for all adverse outcome measures. The strongest association of patients' risk profile and outcome was present for cerebrovascular events and acute renal failure after TAVI. Independent of patients' risk, the latter showed the strongest relation with early mortality after TAVI.CONCLUSIONS: Differentiated outcomes after TAVI can be assessed using claims-based data and are highly dependent on patients' risk profile. The present study might be of use to define risk-adjusted outcome margins for TAVI patients in Germany on the basis of health-insurance data.",
keywords = "Aortic Valve/surgery, Aortic Valve Stenosis, Frailty, Germany/epidemiology, Heart Valve Prosthesis Implantation/adverse effects, Humans, Risk Factors, Transcatheter Aortic Valve Replacement/adverse effects, Treatment Outcome",
author = "Niklas Schofer and Elke Jeschke and Janine Kr{\"o}ger and Henning Baberg and Volkmar Falk and Gummert, {Jan F} and Hamm, {Christian W} and Martin M{\"o}ckel and Alina Go{\ss}ling and J{\"u}rgen Malzahn and Christian G{\"u}nster and Stefan Blankenberg",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = aug,
doi = "10.1007/s00392-022-02009-y",
language = "English",
volume = "111",
pages = "934--943",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "8",

}

RIS

TY - JOUR

T1 - Risk-related short-term clinical outcomes after transcatheter aortic valve implantation and their impact on early mortality: an analysis of claims-based data from Germany

AU - Schofer, Niklas

AU - Jeschke, Elke

AU - Kröger, Janine

AU - Baberg, Henning

AU - Falk, Volkmar

AU - Gummert, Jan F

AU - Hamm, Christian W

AU - Möckel, Martin

AU - Goßling, Alina

AU - Malzahn, Jürgen

AU - Günster, Christian

AU - Blankenberg, Stefan

N1 - © 2022. The Author(s).

PY - 2022/8

Y1 - 2022/8

N2 - OBJECTIVES: We aimed to define and assess risk-specific adverse outcomes after transcatheter aortic valve implantation (TAVI) in an all-comers patient population based on German administrative claims data.METHODS: Administrative claims data of patients undergoing transvascular TAVI between 2017 and 2019 derived from the largest provider of statutory health-care insurance in Germany were used. Patients' risk profile was assessed using the established Hospital Frailty Risk (HFR) score and 30-day adverse events were evaluated. Multivariable logistic regression models were applied to investigate the relation of patients' risk factors to clinical outcomes and, subsequently, of clinical outcomes to mortality.RESULTS: A total of 21,430 patients were included in the analysis. Of those, 51% were categorized as low-, 37% as intermediate-, and 12% as high-risk TAVI patients according to HFR score. Whereas low-risk TAVI patients showed low rates of periprocedural adverse events, TAVI patients at intermediate or high risk suffered from worse outcomes. An increase in HFR score was associated with an increased risk for all adverse outcome measures. The strongest association of patients' risk profile and outcome was present for cerebrovascular events and acute renal failure after TAVI. Independent of patients' risk, the latter showed the strongest relation with early mortality after TAVI.CONCLUSIONS: Differentiated outcomes after TAVI can be assessed using claims-based data and are highly dependent on patients' risk profile. The present study might be of use to define risk-adjusted outcome margins for TAVI patients in Germany on the basis of health-insurance data.

AB - OBJECTIVES: We aimed to define and assess risk-specific adverse outcomes after transcatheter aortic valve implantation (TAVI) in an all-comers patient population based on German administrative claims data.METHODS: Administrative claims data of patients undergoing transvascular TAVI between 2017 and 2019 derived from the largest provider of statutory health-care insurance in Germany were used. Patients' risk profile was assessed using the established Hospital Frailty Risk (HFR) score and 30-day adverse events were evaluated. Multivariable logistic regression models were applied to investigate the relation of patients' risk factors to clinical outcomes and, subsequently, of clinical outcomes to mortality.RESULTS: A total of 21,430 patients were included in the analysis. Of those, 51% were categorized as low-, 37% as intermediate-, and 12% as high-risk TAVI patients according to HFR score. Whereas low-risk TAVI patients showed low rates of periprocedural adverse events, TAVI patients at intermediate or high risk suffered from worse outcomes. An increase in HFR score was associated with an increased risk for all adverse outcome measures. The strongest association of patients' risk profile and outcome was present for cerebrovascular events and acute renal failure after TAVI. Independent of patients' risk, the latter showed the strongest relation with early mortality after TAVI.CONCLUSIONS: Differentiated outcomes after TAVI can be assessed using claims-based data and are highly dependent on patients' risk profile. The present study might be of use to define risk-adjusted outcome margins for TAVI patients in Germany on the basis of health-insurance data.

KW - Aortic Valve/surgery

KW - Aortic Valve Stenosis

KW - Frailty

KW - Germany/epidemiology

KW - Heart Valve Prosthesis Implantation/adverse effects

KW - Humans

KW - Risk Factors

KW - Transcatheter Aortic Valve Replacement/adverse effects

KW - Treatment Outcome

U2 - 10.1007/s00392-022-02009-y

DO - 10.1007/s00392-022-02009-y

M3 - SCORING: Journal article

C2 - 35325270

VL - 111

SP - 934

EP - 943

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 8

ER -