Risk-adjusted active tuberculosis case finding strategy in central Ethiopia
Standard
Risk-adjusted active tuberculosis case finding strategy in central Ethiopia. / Fuchs, Andre; Tufa, Tafese Beyene; Pfäfflin, Frieder; Schönfeld, Andreas; Nordmann, Tamara; Melaku, Fikru; Sorsa, Abebe; Orth, Hans Martin; Häussinger, Dieter; Luedde, Tom; Feldt, Torsten.
In: IJID Regions, Vol. 3, 06.2022, p. 196-203.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Risk-adjusted active tuberculosis case finding strategy in central Ethiopia
AU - Fuchs, Andre
AU - Tufa, Tafese Beyene
AU - Pfäfflin, Frieder
AU - Schönfeld, Andreas
AU - Nordmann, Tamara
AU - Melaku, Fikru
AU - Sorsa, Abebe
AU - Orth, Hans Martin
AU - Häussinger, Dieter
AU - Luedde, Tom
AU - Feldt, Torsten
N1 - © 2022 The Authors.
PY - 2022/6
Y1 - 2022/6
N2 - BACKGROUND: The World Health Organization recommends active case finding for tuberculosis (TB). Our study evaluated the targeted screening of household contacts (HHCs) of patients with contagious pulmonary tuberculosis (PTB) in Central Ethiopia.METHODS: The HHCs of patients with microbiologically confirmed PTB were screened for TB symptoms and risk factors for TB transmission. Symptomatic HHCs were subjected to secondary investigation. Antimicrobial resistance was investigated among study participants.RESULTS: Overall, 112 index patients with TB were included, and 289 HHCs from 89 households were screened. Multidrug-resistant-TB was detected in 2.7% (n=3) of index patients. The routine public health system process did not identify any TB suspects among HHCs. In total, 23.9% (n=69) of HHCs reported ≥1 TB symptom and PTB was confirmed in 2.1% (n=6). Reporting >1 TB symptom (relative risk [RR] 29.4, 95% CI 3.5-245.5, P<0.001) and night sweats (RR 27.1, 95% CI 3.2-226.6, P<0.001) were associated with the greatest relative risk. Regular alcohol consumption was identified as an individual risk factor for TB among HHCs (P=0.022).CONCLUSION: The MDR-TB rate among our patients was higher than recently reported for Ethiopia. Enhanced contact tracing using a risk-adjusted approach seems feasible and increases the case detection rate among HHCs of confirmed TB cases.
AB - BACKGROUND: The World Health Organization recommends active case finding for tuberculosis (TB). Our study evaluated the targeted screening of household contacts (HHCs) of patients with contagious pulmonary tuberculosis (PTB) in Central Ethiopia.METHODS: The HHCs of patients with microbiologically confirmed PTB were screened for TB symptoms and risk factors for TB transmission. Symptomatic HHCs were subjected to secondary investigation. Antimicrobial resistance was investigated among study participants.RESULTS: Overall, 112 index patients with TB were included, and 289 HHCs from 89 households were screened. Multidrug-resistant-TB was detected in 2.7% (n=3) of index patients. The routine public health system process did not identify any TB suspects among HHCs. In total, 23.9% (n=69) of HHCs reported ≥1 TB symptom and PTB was confirmed in 2.1% (n=6). Reporting >1 TB symptom (relative risk [RR] 29.4, 95% CI 3.5-245.5, P<0.001) and night sweats (RR 27.1, 95% CI 3.2-226.6, P<0.001) were associated with the greatest relative risk. Regular alcohol consumption was identified as an individual risk factor for TB among HHCs (P=0.022).CONCLUSION: The MDR-TB rate among our patients was higher than recently reported for Ethiopia. Enhanced contact tracing using a risk-adjusted approach seems feasible and increases the case detection rate among HHCs of confirmed TB cases.
U2 - 10.1016/j.ijregi.2022.03.012
DO - 10.1016/j.ijregi.2022.03.012
M3 - SCORING: Journal article
C2 - 35755475
VL - 3
SP - 196
EP - 203
JO - IJID Regions
JF - IJID Regions
SN - 2772-7076
ER -