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Risk prediction of in-hospital mortality in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: The ECMO-ACCEPTS score

Standard

Risk prediction of in-hospital mortality in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: The ECMO-ACCEPTS score. / Becher, Peter M; Twerenbold, Raphael; Schrage, Benedikt; Schmack, Bastian; Sinning, Christoph R; Fluschnik, Nina; Schwarzl, Michael; Waldeyer, Christoph; Seiffert, Moritz; Clemmensen, Peter; Neumann, Johannes T; Bernhardt, Alexander M; Zeymer, Uwe; Thiele, Holger; Reichenspurner, Hermann; Blankenberg, Stefan; Westermann, Dirk.

In: J CRIT CARE, Vol. 56, 04.2020, p. 100-105.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Becher, PM, Twerenbold, R, Schrage, B, Schmack, B, Sinning, CR, Fluschnik, N, Schwarzl, M, Waldeyer, C, Seiffert, M, Clemmensen, P, Neumann, JT, Bernhardt, AM, Zeymer, U, Thiele, H, Reichenspurner, H, Blankenberg, S & Westermann, D 2020, 'Risk prediction of in-hospital mortality in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: The ECMO-ACCEPTS score', J CRIT CARE, vol. 56, pp. 100-105. https://doi.org/10.1016/j.jcrc.2019.12.013

APA

Becher, P. M., Twerenbold, R., Schrage, B., Schmack, B., Sinning, C. R., Fluschnik, N., Schwarzl, M., Waldeyer, C., Seiffert, M., Clemmensen, P., Neumann, J. T., Bernhardt, A. M., Zeymer, U., Thiele, H., Reichenspurner, H., Blankenberg, S., & Westermann, D. (2020). Risk prediction of in-hospital mortality in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: The ECMO-ACCEPTS score. J CRIT CARE, 56, 100-105. https://doi.org/10.1016/j.jcrc.2019.12.013

Vancouver

Becher PM, Twerenbold R, Schrage B, Schmack B, Sinning CR, Fluschnik N et al. Risk prediction of in-hospital mortality in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: The ECMO-ACCEPTS score. J CRIT CARE. 2020 Apr;56:100-105. https://doi.org/10.1016/j.jcrc.2019.12.013

Bibtex

@article{998925048dfc47bda38fd72595a541cb,
title = "Risk prediction of in-hospital mortality in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: The ECMO-ACCEPTS score",
abstract = "PURPOSE: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is an increasingly used treatment option for patients in need of mechanical cardiopulmonary support, while available outcome data is limited. The aim of this study was to identify predictors for 30-day in-hospital mortality.MATERIAL AND METHODS: We analyzed baseline characteristics and outcomes of 8351 VA-ECMO procedures performed in Germany from 2007 to 2015. Using a multivariable model, we identified the ten most important variables to allow for prediction of 30-day in-hospital mortality. Based on these variables, we created a mortality prediction score (ECMO-ACCEPTS score) to enhance decision making in patients considered for or treated with VA-ECMO support.RESULTS: Of 8351 patients (71.7% male) 3567 had prior CPR. Mean age was 62 years in the present cohort. The overall 30-day in-hospital mortality was 61%. The ECMO-ACCEPTS score, derived among randomly selected 4175 patients, included ten independent predictors for in-hospital mortality. Internal validation in the remaining 4176 patients confirmed strong differentiation between low and high risk of 30-day in-hospital mortality (r = 0.97 for correlation of predicted with observed mortality, p < .001).CONCLUSIONS: The ECMO-ACCEPTS score might help clinicians to improve risk prediction among VA-ECMO patients for refractory cardiogenic shock.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Calibration, Cohort Studies, Decision Making, Extracorporeal Membrane Oxygenation/methods, Female, Germany/epidemiology, Hospital Mortality, Humans, Male, Middle Aged, Multivariate Analysis, Regression Analysis, Retrospective Studies, Severity of Illness Index, Shock, Cardiogenic/mortality, Young Adult",
author = "Becher, {Peter M} and Raphael Twerenbold and Benedikt Schrage and Bastian Schmack and Sinning, {Christoph R} and Nina Fluschnik and Michael Schwarzl and Christoph Waldeyer and Moritz Seiffert and Peter Clemmensen and Neumann, {Johannes T} and Bernhardt, {Alexander M} and Uwe Zeymer and Holger Thiele and Hermann Reichenspurner and Stefan Blankenberg and Dirk Westermann",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2020",
month = apr,
doi = "10.1016/j.jcrc.2019.12.013",
language = "English",
volume = "56",
pages = "100--105",
journal = "J CRIT CARE",
issn = "0883-9441",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Risk prediction of in-hospital mortality in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: The ECMO-ACCEPTS score

AU - Becher, Peter M

AU - Twerenbold, Raphael

AU - Schrage, Benedikt

AU - Schmack, Bastian

AU - Sinning, Christoph R

AU - Fluschnik, Nina

AU - Schwarzl, Michael

AU - Waldeyer, Christoph

AU - Seiffert, Moritz

AU - Clemmensen, Peter

AU - Neumann, Johannes T

AU - Bernhardt, Alexander M

AU - Zeymer, Uwe

AU - Thiele, Holger

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Westermann, Dirk

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2020/4

Y1 - 2020/4

N2 - PURPOSE: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is an increasingly used treatment option for patients in need of mechanical cardiopulmonary support, while available outcome data is limited. The aim of this study was to identify predictors for 30-day in-hospital mortality.MATERIAL AND METHODS: We analyzed baseline characteristics and outcomes of 8351 VA-ECMO procedures performed in Germany from 2007 to 2015. Using a multivariable model, we identified the ten most important variables to allow for prediction of 30-day in-hospital mortality. Based on these variables, we created a mortality prediction score (ECMO-ACCEPTS score) to enhance decision making in patients considered for or treated with VA-ECMO support.RESULTS: Of 8351 patients (71.7% male) 3567 had prior CPR. Mean age was 62 years in the present cohort. The overall 30-day in-hospital mortality was 61%. The ECMO-ACCEPTS score, derived among randomly selected 4175 patients, included ten independent predictors for in-hospital mortality. Internal validation in the remaining 4176 patients confirmed strong differentiation between low and high risk of 30-day in-hospital mortality (r = 0.97 for correlation of predicted with observed mortality, p < .001).CONCLUSIONS: The ECMO-ACCEPTS score might help clinicians to improve risk prediction among VA-ECMO patients for refractory cardiogenic shock.

AB - PURPOSE: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is an increasingly used treatment option for patients in need of mechanical cardiopulmonary support, while available outcome data is limited. The aim of this study was to identify predictors for 30-day in-hospital mortality.MATERIAL AND METHODS: We analyzed baseline characteristics and outcomes of 8351 VA-ECMO procedures performed in Germany from 2007 to 2015. Using a multivariable model, we identified the ten most important variables to allow for prediction of 30-day in-hospital mortality. Based on these variables, we created a mortality prediction score (ECMO-ACCEPTS score) to enhance decision making in patients considered for or treated with VA-ECMO support.RESULTS: Of 8351 patients (71.7% male) 3567 had prior CPR. Mean age was 62 years in the present cohort. The overall 30-day in-hospital mortality was 61%. The ECMO-ACCEPTS score, derived among randomly selected 4175 patients, included ten independent predictors for in-hospital mortality. Internal validation in the remaining 4176 patients confirmed strong differentiation between low and high risk of 30-day in-hospital mortality (r = 0.97 for correlation of predicted with observed mortality, p < .001).CONCLUSIONS: The ECMO-ACCEPTS score might help clinicians to improve risk prediction among VA-ECMO patients for refractory cardiogenic shock.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Calibration

KW - Cohort Studies

KW - Decision Making

KW - Extracorporeal Membrane Oxygenation/methods

KW - Female

KW - Germany/epidemiology

KW - Hospital Mortality

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Regression Analysis

KW - Retrospective Studies

KW - Severity of Illness Index

KW - Shock, Cardiogenic/mortality

KW - Young Adult

U2 - 10.1016/j.jcrc.2019.12.013

DO - 10.1016/j.jcrc.2019.12.013

M3 - SCORING: Journal article

C2 - 31896442

VL - 56

SP - 100

EP - 105

JO - J CRIT CARE

JF - J CRIT CARE

SN - 0883-9441

ER -