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Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging.

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Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging. / Singer, Oliver C; Humpich, Marek C; Fiehler, Jens; Albers, Gregory W; Lansberg, Maarten G; Kastrup, Andiras; Rovira, Alex; Liebeskind, David S; Gass, Achim; Rosso, Charlotte; Derex, Laurent; Kim, Jong S; Neumann-Haefelin, Tobias.

In: ANN NEUROL, Vol. 63, No. 1, 1, 2008, p. 52-60.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Singer, OC, Humpich, MC, Fiehler, J, Albers, GW, Lansberg, MG, Kastrup, A, Rovira, A, Liebeskind, DS, Gass, A, Rosso, C, Derex, L, Kim, JS & Neumann-Haefelin, T 2008, 'Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging.', ANN NEUROL, vol. 63, no. 1, 1, pp. 52-60. <http://www.ncbi.nlm.nih.gov/pubmed/17880020?dopt=Citation>

APA

Singer, O. C., Humpich, M. C., Fiehler, J., Albers, G. W., Lansberg, M. G., Kastrup, A., Rovira, A., Liebeskind, D. S., Gass, A., Rosso, C., Derex, L., Kim, J. S., & Neumann-Haefelin, T. (2008). Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging. ANN NEUROL, 63(1), 52-60. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17880020?dopt=Citation

Vancouver

Singer OC, Humpich MC, Fiehler J, Albers GW, Lansberg MG, Kastrup A et al. Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging. ANN NEUROL. 2008;63(1):52-60. 1.

Bibtex

@article{314a56710f1344718cf06813c1cf0444,
title = "Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging.",
abstract = "OBJECTIVE: The risk for symptomatic intracerebral hemorrhage (sICH) associated with thrombolytic treatment has not been evaluated in large studies using diffusion-weighted imaging (DWI). Here, we investigated the relation between pretreatment DWI lesion size and the risk for sICH after thrombolysis. METHODS: In this retrospective multicenter study, prospectively collected data from 645 patients with anterior circulation stroke treated with intravenous or intraarterial thrombolysis within 6 hours (100 ml; n = 56) DWI lesions. RESULTS: In total, 44 (6.8%) patients experienced development of sICH. The sICH rate was significantly different between subgroups: 2.8, 7.8, and 16.1% in patients with small, moderate, and large DWI lesions, respectively (p <0.05). This translates to a 5.8 (2.8)-fold greater sICH risk for patients with large DWI lesions as compared with patients with small (or moderate) DWI lesions. The results were similar in the large subgroup (n = 536) of patients treated with intravenous tissue plasminogen activator. DWI lesion size remained an independent risk factor when including National Institutes of Health Stroke Scale, age, time to thrombolysis, and leukoariosis in a logistic regression analysis. INTERPRETATION: This multicenter study provides estimates of sICH risk in potential candidates for thrombolysis. The sICH risk increases gradually with increasing DWI lesion size, indicating that the potential benefit of therapy needs to be balanced carefully against the risk for sICH, especially in patients with large DWI lesions.",
author = "Singer, {Oliver C} and Humpich, {Marek C} and Jens Fiehler and Albers, {Gregory W} and Lansberg, {Maarten G} and Andiras Kastrup and Alex Rovira and Liebeskind, {David S} and Achim Gass and Charlotte Rosso and Laurent Derex and Kim, {Jong S} and Tobias Neumann-Haefelin",
year = "2008",
language = "Deutsch",
volume = "63",
pages = "52--60",
journal = "ANN NEUROL",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging.

AU - Singer, Oliver C

AU - Humpich, Marek C

AU - Fiehler, Jens

AU - Albers, Gregory W

AU - Lansberg, Maarten G

AU - Kastrup, Andiras

AU - Rovira, Alex

AU - Liebeskind, David S

AU - Gass, Achim

AU - Rosso, Charlotte

AU - Derex, Laurent

AU - Kim, Jong S

AU - Neumann-Haefelin, Tobias

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: The risk for symptomatic intracerebral hemorrhage (sICH) associated with thrombolytic treatment has not been evaluated in large studies using diffusion-weighted imaging (DWI). Here, we investigated the relation between pretreatment DWI lesion size and the risk for sICH after thrombolysis. METHODS: In this retrospective multicenter study, prospectively collected data from 645 patients with anterior circulation stroke treated with intravenous or intraarterial thrombolysis within 6 hours (100 ml; n = 56) DWI lesions. RESULTS: In total, 44 (6.8%) patients experienced development of sICH. The sICH rate was significantly different between subgroups: 2.8, 7.8, and 16.1% in patients with small, moderate, and large DWI lesions, respectively (p <0.05). This translates to a 5.8 (2.8)-fold greater sICH risk for patients with large DWI lesions as compared with patients with small (or moderate) DWI lesions. The results were similar in the large subgroup (n = 536) of patients treated with intravenous tissue plasminogen activator. DWI lesion size remained an independent risk factor when including National Institutes of Health Stroke Scale, age, time to thrombolysis, and leukoariosis in a logistic regression analysis. INTERPRETATION: This multicenter study provides estimates of sICH risk in potential candidates for thrombolysis. The sICH risk increases gradually with increasing DWI lesion size, indicating that the potential benefit of therapy needs to be balanced carefully against the risk for sICH, especially in patients with large DWI lesions.

AB - OBJECTIVE: The risk for symptomatic intracerebral hemorrhage (sICH) associated with thrombolytic treatment has not been evaluated in large studies using diffusion-weighted imaging (DWI). Here, we investigated the relation between pretreatment DWI lesion size and the risk for sICH after thrombolysis. METHODS: In this retrospective multicenter study, prospectively collected data from 645 patients with anterior circulation stroke treated with intravenous or intraarterial thrombolysis within 6 hours (100 ml; n = 56) DWI lesions. RESULTS: In total, 44 (6.8%) patients experienced development of sICH. The sICH rate was significantly different between subgroups: 2.8, 7.8, and 16.1% in patients with small, moderate, and large DWI lesions, respectively (p <0.05). This translates to a 5.8 (2.8)-fold greater sICH risk for patients with large DWI lesions as compared with patients with small (or moderate) DWI lesions. The results were similar in the large subgroup (n = 536) of patients treated with intravenous tissue plasminogen activator. DWI lesion size remained an independent risk factor when including National Institutes of Health Stroke Scale, age, time to thrombolysis, and leukoariosis in a logistic regression analysis. INTERPRETATION: This multicenter study provides estimates of sICH risk in potential candidates for thrombolysis. The sICH risk increases gradually with increasing DWI lesion size, indicating that the potential benefit of therapy needs to be balanced carefully against the risk for sICH, especially in patients with large DWI lesions.

M3 - SCORING: Zeitschriftenaufsatz

VL - 63

SP - 52

EP - 60

JO - ANN NEUROL

JF - ANN NEUROL

SN - 0364-5134

IS - 1

M1 - 1

ER -