Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation
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Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation. / Camen, Stephan; Csengeri, Dora; Geelhoed, Bastiaan; Niiranen, Teemu; Gianfagna, Francesco; Vishram-Nielsen, Julie K; Costanzo, Simona; Söderberg, Stefan; Vartiainen, Erkki; Börschel, Christin S; Donati, Maria Benedetta; Løchen, Maja-Lisa; Ojeda, Francisco M; Kontto, Jukka; Mathiesen, Ellisiv B; Jensen, Steen; Koenig, Wolfgang; Kee, Frank; de Gaetano, Giovanni; Zeller, Tanja; Jørgensen, Torben; Tunstall-Pedoe, Hugh; Blankenberg, Stefan; Kuulasmaa, Kari; Linneberg, Allan; Salomaa, Veikko; Iacoviello, Licia; Schnabel, Renate B.
In: J AM HEART ASSOC, Vol. 11, No. 7, e024299, 05.04.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation
AU - Camen, Stephan
AU - Csengeri, Dora
AU - Geelhoed, Bastiaan
AU - Niiranen, Teemu
AU - Gianfagna, Francesco
AU - Vishram-Nielsen, Julie K
AU - Costanzo, Simona
AU - Söderberg, Stefan
AU - Vartiainen, Erkki
AU - Börschel, Christin S
AU - Donati, Maria Benedetta
AU - Løchen, Maja-Lisa
AU - Ojeda, Francisco M
AU - Kontto, Jukka
AU - Mathiesen, Ellisiv B
AU - Jensen, Steen
AU - Koenig, Wolfgang
AU - Kee, Frank
AU - de Gaetano, Giovanni
AU - Zeller, Tanja
AU - Jørgensen, Torben
AU - Tunstall-Pedoe, Hugh
AU - Blankenberg, Stefan
AU - Kuulasmaa, Kari
AU - Linneberg, Allan
AU - Salomaa, Veikko
AU - Iacoviello, Licia
AU - Schnabel, Renate B
PY - 2022/4/5
Y1 - 2022/4/5
N2 - Background Although myocardial infarction (MI) and atrial fibrillation (AF) are frequent comorbidities and share common cardiovascular risk factors, the direction and strength of the association of the risk factors with disease onset, subsequent disease incidence, and mortality are not completely understood. Methods and Results In pooled multivariable Cox regression analyses, we examined temporal relations of disease onset and identified predictors of MI, AF, and all-cause mortality in 108 363 individuals (median age, 46.0 years; 48.2% men) free of MI and AF at baseline from 6 European population-based cohorts. During a maximum follow-up of 10.0 years, 3558 (3.3%) individuals were diagnosed exclusively with MI, 1922 (1.8%) with AF but no MI, and 491 (0.5%) individuals developed both MI and AF. Association of sex, systolic blood pressure, antihypertensive treatment, and diabetes appeared to be stronger with incident MI than with AF, whereas increasing age and body mass index showed a higher risk for incident AF. Total cholesterol and daily smoking were significantly related to incident MI but not AF. Combined population attributable fraction of cardiovascular risk factors was >70% for incident MI, whereas it was only 27% for AF. Subsequent MI after AF (hazard ratio [HR], 1.68; 95% CI, 1.03-2.74) and subsequent AF after MI (HR, 1.75; 95% CI, 1.31-2.34) both significantly increased overall mortality risk. Conclusions We observed different associations of cardiovascular risk factors with both diseases indicating distinct pathophysiological pathways. Subsequent diagnoses of MI and AF significantly increased mortality risk.
AB - Background Although myocardial infarction (MI) and atrial fibrillation (AF) are frequent comorbidities and share common cardiovascular risk factors, the direction and strength of the association of the risk factors with disease onset, subsequent disease incidence, and mortality are not completely understood. Methods and Results In pooled multivariable Cox regression analyses, we examined temporal relations of disease onset and identified predictors of MI, AF, and all-cause mortality in 108 363 individuals (median age, 46.0 years; 48.2% men) free of MI and AF at baseline from 6 European population-based cohorts. During a maximum follow-up of 10.0 years, 3558 (3.3%) individuals were diagnosed exclusively with MI, 1922 (1.8%) with AF but no MI, and 491 (0.5%) individuals developed both MI and AF. Association of sex, systolic blood pressure, antihypertensive treatment, and diabetes appeared to be stronger with incident MI than with AF, whereas increasing age and body mass index showed a higher risk for incident AF. Total cholesterol and daily smoking were significantly related to incident MI but not AF. Combined population attributable fraction of cardiovascular risk factors was >70% for incident MI, whereas it was only 27% for AF. Subsequent MI after AF (hazard ratio [HR], 1.68; 95% CI, 1.03-2.74) and subsequent AF after MI (HR, 1.75; 95% CI, 1.31-2.34) both significantly increased overall mortality risk. Conclusions We observed different associations of cardiovascular risk factors with both diseases indicating distinct pathophysiological pathways. Subsequent diagnoses of MI and AF significantly increased mortality risk.
KW - Atrial Fibrillation/diagnosis
KW - Female
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Myocardial Infarction/diagnosis
KW - Prognosis
KW - Proportional Hazards Models
KW - Risk Factors
U2 - 10.1161/JAHA.121.024299
DO - 10.1161/JAHA.121.024299
M3 - SCORING: Journal article
C2 - 35322680
VL - 11
JO - J AM HEART ASSOC
JF - J AM HEART ASSOC
SN - 2047-9980
IS - 7
M1 - e024299
ER -
