Risk factors for heart failure are associated with alterations of the LV end-diastolic pressure-volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort
Standard
Risk factors for heart failure are associated with alterations of the LV end-diastolic pressure-volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort. / Schwarzl, Michael; Ojeda, Francisco; Zeller, Tanja; Seiffert, Moritz; Becher, Peter M; Munzel, Thomas; Wild, Philipp S; Blettner, Maria; Lackner, Karl J; Pfeiffer, Norbert; Beutel, Manfred E; Blankenberg, Stefan; Westermann, Dirk.
In: EUR HEART J, Vol. 37, No. 23, 14.06.2016, p. 1807-1814.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Risk factors for heart failure are associated with alterations of the LV end-diastolic pressure-volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort
AU - Schwarzl, Michael
AU - Ojeda, Francisco
AU - Zeller, Tanja
AU - Seiffert, Moritz
AU - Becher, Peter M
AU - Munzel, Thomas
AU - Wild, Philipp S
AU - Blettner, Maria
AU - Lackner, Karl J
AU - Pfeiffer, Norbert
AU - Beutel, Manfred E
AU - Blankenberg, Stefan
AU - Westermann, Dirk
N1 - Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.
PY - 2016/6/14
Y1 - 2016/6/14
N2 - AIMS: Left-ventricular (LV) remodelling impacts on the LV end-diastolic pressure-volume relationship (EDPVR), which is different in heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). In a large-scale, population-based cohort (Gutenberg Health Study), we aimed to investigate alterations of the EDPVR in HF patients and their association to risk factors and all-cause mortality in non-HF individuals.METHODS AND RESULTS: Based on clinical and echocardiographic data, participants were divided into 'No HF' (n = 14487), HFrEF (n = 215), and HFpEF (n = 79). We estimated the position of the EDPVR and its stiffness-coefficient β from echocardiographic data using a single-beat method. The EDPVR was shifted rightward in HFrEF and leftward in HFpEF compared with 'No HF', while the stiffness-coefficient β was increased in both HFrEF and HFpEF. In 'No HF', a higher stiffness-coefficient β was associated with age, female gender, hypertension, diabetes, and obesity, while age and female gender were associated with a leftward shift of the EDPVR, whereas dyslipidaemia, obesity, smoking, and impaired renal function were associated with a rightward shift of the EDPVR. Both changes of the EDPVR were associated with increased all-cause mortality.CONCLUSION: In a large-scale, population-based cohort, we show distinct alterations of the EDPVR in HFrEF and HFpEF. Already in non-HF individuals, the presence of risk factors for HF is linked alterations of the EDPVR, which are associated with increased mortality.
AB - AIMS: Left-ventricular (LV) remodelling impacts on the LV end-diastolic pressure-volume relationship (EDPVR), which is different in heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). In a large-scale, population-based cohort (Gutenberg Health Study), we aimed to investigate alterations of the EDPVR in HF patients and their association to risk factors and all-cause mortality in non-HF individuals.METHODS AND RESULTS: Based on clinical and echocardiographic data, participants were divided into 'No HF' (n = 14487), HFrEF (n = 215), and HFpEF (n = 79). We estimated the position of the EDPVR and its stiffness-coefficient β from echocardiographic data using a single-beat method. The EDPVR was shifted rightward in HFrEF and leftward in HFpEF compared with 'No HF', while the stiffness-coefficient β was increased in both HFrEF and HFpEF. In 'No HF', a higher stiffness-coefficient β was associated with age, female gender, hypertension, diabetes, and obesity, while age and female gender were associated with a leftward shift of the EDPVR, whereas dyslipidaemia, obesity, smoking, and impaired renal function were associated with a rightward shift of the EDPVR. Both changes of the EDPVR were associated with increased all-cause mortality.CONCLUSION: In a large-scale, population-based cohort, we show distinct alterations of the EDPVR in HFrEF and HFpEF. Already in non-HF individuals, the presence of risk factors for HF is linked alterations of the EDPVR, which are associated with increased mortality.
KW - Adult
KW - Aged
KW - Cardiac Volume/physiology
KW - Cause of Death
KW - Echocardiography
KW - Female
KW - Germany/epidemiology
KW - Heart Failure/mortality
KW - Humans
KW - Kaplan-Meier Estimate
KW - Male
KW - Middle Aged
KW - Natriuretic Peptide, Brain/metabolism
KW - Peptide Fragments/metabolism
KW - Prognosis
KW - Prospective Studies
KW - Risk Factors
KW - Stroke Volume/physiology
KW - Ventricular Dysfunction, Left/mortality
KW - Ventricular Pressure/physiology
KW - Ventricular Remodeling/physiology
U2 - 10.1093/eurheartj/ehw120
DO - 10.1093/eurheartj/ehw120
M3 - SCORING: Journal article
C2 - 27055814
VL - 37
SP - 1807
EP - 1814
JO - EUR HEART J
JF - EUR HEART J
SN - 0195-668X
IS - 23
ER -
