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Risk factors and seroprevalence of hepatitis E evaluated in frozen-serum samples (2002-2003) of pregnant women compared with female blood donors in a Southern region of Brazil

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Risk factors and seroprevalence of hepatitis E evaluated in frozen-serum samples (2002-2003) of pregnant women compared with female blood donors in a Southern region of Brazil. / Hardtke, S; Rocco, R; Ogata, J; Braga, S; Barbosa, M; Wranke, A; Doi, E; da Cunha, D; Maluf, E; Wedemeyer, H; Muzzillo, D.

In: J MED VIROL, Vol. 90, No. 12, 12.2018, p. 1856-1862.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hardtke, S, Rocco, R, Ogata, J, Braga, S, Barbosa, M, Wranke, A, Doi, E, da Cunha, D, Maluf, E, Wedemeyer, H & Muzzillo, D 2018, 'Risk factors and seroprevalence of hepatitis E evaluated in frozen-serum samples (2002-2003) of pregnant women compared with female blood donors in a Southern region of Brazil', J MED VIROL, vol. 90, no. 12, pp. 1856-1862. https://doi.org/10.1002/jmv.25274

APA

Hardtke, S., Rocco, R., Ogata, J., Braga, S., Barbosa, M., Wranke, A., Doi, E., da Cunha, D., Maluf, E., Wedemeyer, H., & Muzzillo, D. (2018). Risk factors and seroprevalence of hepatitis E evaluated in frozen-serum samples (2002-2003) of pregnant women compared with female blood donors in a Southern region of Brazil. J MED VIROL, 90(12), 1856-1862. https://doi.org/10.1002/jmv.25274

Vancouver

Hardtke S, Rocco R, Ogata J, Braga S, Barbosa M, Wranke A et al. Risk factors and seroprevalence of hepatitis E evaluated in frozen-serum samples (2002-2003) of pregnant women compared with female blood donors in a Southern region of Brazil. J MED VIROL. 2018 Dec;90(12):1856-1862. https://doi.org/10.1002/jmv.25274

Bibtex

@article{16a7495116554a48951dcf0d455faa04,
title = "Risk factors and seroprevalence of hepatitis E evaluated in frozen-serum samples (2002-2003) of pregnant women compared with female blood donors in a Southern region of Brazil",
abstract = "Hepatitis E has always been related to morbidity in pregnant women. Its epidemiology is not well understood in Brazil. Therefore, we tested sera from 209 pregnant women and 199 female blood donors, collected at a single center in Curitiba, Brazil. The Wantai assay was used for testing the anti-hepatitis E virus (anti-HEV), immunoglobulin G (IgG), and an in-house polymerase chain reaction process for testing HEV RNA. Anti-HEV was detected in 22.5% of the total group, 19% in the pregnant women group, and 26% in the blood donor group (P = 0.11), a much higher prevalence when compared with other studies in Brazil. Demographical analysis showed that 92.4% were born in the South Region of Brazil, 4.9% in the Southeast, and 2.7% were distributed over other regions of the country. With respect to their origin, 99% were from the South, 0.7% from the Southeast, and 0.2% from the Central-West regions. Income, education, race, number of pregnancies, and abortion did differ significantly when comparing both the groups (P < 0.001). Age >30 (P = 0.012) and the number (>3) of pregnancies (P = 0.008) were related to anti-HEV positivity. All anti-HEV IgG-positive females were HEV RNA negative. In conclusion, HEV positivity was found in one out of five young women, which showed an urgent need for further epidemiological studies in Brazil.",
keywords = "Adult, Blood Donors, Brazil/epidemiology, Cohort Studies, Female, Hepatitis Antibodies/blood, Hepatitis E/epidemiology, Humans, Immunoglobulin G/blood, Polymerase Chain Reaction, Pregnancy, Pregnant Women, RNA, Viral/blood, Risk Factors, Seroepidemiologic Studies, Surveys and Questionnaires",
author = "S Hardtke and R Rocco and J Ogata and S Braga and M Barbosa and A Wranke and E Doi and {da Cunha}, D and E Maluf and H Wedemeyer and D Muzzillo",
note = "{\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = dec,
doi = "10.1002/jmv.25274",
language = "English",
volume = "90",
pages = "1856--1862",
journal = "J MED VIROL",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Risk factors and seroprevalence of hepatitis E evaluated in frozen-serum samples (2002-2003) of pregnant women compared with female blood donors in a Southern region of Brazil

AU - Hardtke, S

AU - Rocco, R

AU - Ogata, J

AU - Braga, S

AU - Barbosa, M

AU - Wranke, A

AU - Doi, E

AU - da Cunha, D

AU - Maluf, E

AU - Wedemeyer, H

AU - Muzzillo, D

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2018/12

Y1 - 2018/12

N2 - Hepatitis E has always been related to morbidity in pregnant women. Its epidemiology is not well understood in Brazil. Therefore, we tested sera from 209 pregnant women and 199 female blood donors, collected at a single center in Curitiba, Brazil. The Wantai assay was used for testing the anti-hepatitis E virus (anti-HEV), immunoglobulin G (IgG), and an in-house polymerase chain reaction process for testing HEV RNA. Anti-HEV was detected in 22.5% of the total group, 19% in the pregnant women group, and 26% in the blood donor group (P = 0.11), a much higher prevalence when compared with other studies in Brazil. Demographical analysis showed that 92.4% were born in the South Region of Brazil, 4.9% in the Southeast, and 2.7% were distributed over other regions of the country. With respect to their origin, 99% were from the South, 0.7% from the Southeast, and 0.2% from the Central-West regions. Income, education, race, number of pregnancies, and abortion did differ significantly when comparing both the groups (P < 0.001). Age >30 (P = 0.012) and the number (>3) of pregnancies (P = 0.008) were related to anti-HEV positivity. All anti-HEV IgG-positive females were HEV RNA negative. In conclusion, HEV positivity was found in one out of five young women, which showed an urgent need for further epidemiological studies in Brazil.

AB - Hepatitis E has always been related to morbidity in pregnant women. Its epidemiology is not well understood in Brazil. Therefore, we tested sera from 209 pregnant women and 199 female blood donors, collected at a single center in Curitiba, Brazil. The Wantai assay was used for testing the anti-hepatitis E virus (anti-HEV), immunoglobulin G (IgG), and an in-house polymerase chain reaction process for testing HEV RNA. Anti-HEV was detected in 22.5% of the total group, 19% in the pregnant women group, and 26% in the blood donor group (P = 0.11), a much higher prevalence when compared with other studies in Brazil. Demographical analysis showed that 92.4% were born in the South Region of Brazil, 4.9% in the Southeast, and 2.7% were distributed over other regions of the country. With respect to their origin, 99% were from the South, 0.7% from the Southeast, and 0.2% from the Central-West regions. Income, education, race, number of pregnancies, and abortion did differ significantly when comparing both the groups (P < 0.001). Age >30 (P = 0.012) and the number (>3) of pregnancies (P = 0.008) were related to anti-HEV positivity. All anti-HEV IgG-positive females were HEV RNA negative. In conclusion, HEV positivity was found in one out of five young women, which showed an urgent need for further epidemiological studies in Brazil.

KW - Adult

KW - Blood Donors

KW - Brazil/epidemiology

KW - Cohort Studies

KW - Female

KW - Hepatitis Antibodies/blood

KW - Hepatitis E/epidemiology

KW - Humans

KW - Immunoglobulin G/blood

KW - Polymerase Chain Reaction

KW - Pregnancy

KW - Pregnant Women

KW - RNA, Viral/blood

KW - Risk Factors

KW - Seroepidemiologic Studies

KW - Surveys and Questionnaires

U2 - 10.1002/jmv.25274

DO - 10.1002/jmv.25274

M3 - SCORING: Journal article

C2 - 30063252

VL - 90

SP - 1856

EP - 1862

JO - J MED VIROL

JF - J MED VIROL

SN - 0146-6615

IS - 12

ER -