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Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development

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Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. / Meyer, Tobias N; Meyer-Schwesinger, Catherine; Sampogna, Rosemary V; Vaughn, Duke A; Stuart, Robert O; Steer, Dylan L; Bush, Kevin T; Nigam, Sanjay K.

In: DIFFERENTIATION, Vol. 74, No. 9-10, 01.12.2006, p. 638-47.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meyer, TN, Meyer-Schwesinger, C, Sampogna, RV, Vaughn, DA, Stuart, RO, Steer, DL, Bush, KT & Nigam, SK 2006, 'Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development', DIFFERENTIATION, vol. 74, no. 9-10, pp. 638-47. https://doi.org/10.1111/j.1432-0436.2006.00102.x

APA

Meyer, T. N., Meyer-Schwesinger, C., Sampogna, R. V., Vaughn, D. A., Stuart, R. O., Steer, D. L., Bush, K. T., & Nigam, S. K. (2006). Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. DIFFERENTIATION, 74(9-10), 638-47. https://doi.org/10.1111/j.1432-0436.2006.00102.x

Vancouver

Meyer TN, Meyer-Schwesinger C, Sampogna RV, Vaughn DA, Stuart RO, Steer DL et al. Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. DIFFERENTIATION. 2006 Dec 1;74(9-10):638-47. https://doi.org/10.1111/j.1432-0436.2006.00102.x

Bibtex

@article{d6a1615830184f36b0e57f8ab6f018f8,
title = "Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development",
abstract = "In this study, five different in vitro assays, which together recapitulate much of kidney development, were used to examine the role of the Rho-associated protein serine/threonine kinase (ROCK) in events central to ureteric bud (UB) and metanephric mesenchyme (MM) morphogenensis, in isolation and together. ROCK activity was found to be critical for (1) cell proliferation, growth, and development of the whole embryonic kidney in organ culture, (2) tip and stalk formation in cultures of isolated UBs, and (3) migration of MM cells (in a novel MM migration assay) during their condensation at UB tips (in a UB/MM recombination assay). Together, the data indicate selective involvement of Rho/ROCK in distinct morphogenetic processes necessary for kidney development and that the coordination of these events by Rho/ROCK provides a potential mechanism to regulate overall branching patterns, nephron formation, and thus, kidney architecture.",
keywords = "Animals, Body Patterning, Cell Movement, Gene Expression Regulation, Developmental, Intracellular Signaling Peptides and Proteins, Kidney, Mesoderm, Morphogenesis, Nephrons, Organ Culture Techniques, Protein-Serine-Threonine Kinases, Rats, Rats, Sprague-Dawley, Ureter, rho-Associated Kinases",
author = "Meyer, {Tobias N} and Catherine Meyer-Schwesinger and Sampogna, {Rosemary V} and Vaughn, {Duke A} and Stuart, {Robert O} and Steer, {Dylan L} and Bush, {Kevin T} and Nigam, {Sanjay K}",
year = "2006",
month = dec,
day = "1",
doi = "10.1111/j.1432-0436.2006.00102.x",
language = "English",
volume = "74",
pages = "638--47",
number = "9-10",

}

RIS

TY - JOUR

T1 - Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development

AU - Meyer, Tobias N

AU - Meyer-Schwesinger, Catherine

AU - Sampogna, Rosemary V

AU - Vaughn, Duke A

AU - Stuart, Robert O

AU - Steer, Dylan L

AU - Bush, Kevin T

AU - Nigam, Sanjay K

PY - 2006/12/1

Y1 - 2006/12/1

N2 - In this study, five different in vitro assays, which together recapitulate much of kidney development, were used to examine the role of the Rho-associated protein serine/threonine kinase (ROCK) in events central to ureteric bud (UB) and metanephric mesenchyme (MM) morphogenensis, in isolation and together. ROCK activity was found to be critical for (1) cell proliferation, growth, and development of the whole embryonic kidney in organ culture, (2) tip and stalk formation in cultures of isolated UBs, and (3) migration of MM cells (in a novel MM migration assay) during their condensation at UB tips (in a UB/MM recombination assay). Together, the data indicate selective involvement of Rho/ROCK in distinct morphogenetic processes necessary for kidney development and that the coordination of these events by Rho/ROCK provides a potential mechanism to regulate overall branching patterns, nephron formation, and thus, kidney architecture.

AB - In this study, five different in vitro assays, which together recapitulate much of kidney development, were used to examine the role of the Rho-associated protein serine/threonine kinase (ROCK) in events central to ureteric bud (UB) and metanephric mesenchyme (MM) morphogenensis, in isolation and together. ROCK activity was found to be critical for (1) cell proliferation, growth, and development of the whole embryonic kidney in organ culture, (2) tip and stalk formation in cultures of isolated UBs, and (3) migration of MM cells (in a novel MM migration assay) during their condensation at UB tips (in a UB/MM recombination assay). Together, the data indicate selective involvement of Rho/ROCK in distinct morphogenetic processes necessary for kidney development and that the coordination of these events by Rho/ROCK provides a potential mechanism to regulate overall branching patterns, nephron formation, and thus, kidney architecture.

KW - Animals

KW - Body Patterning

KW - Cell Movement

KW - Gene Expression Regulation, Developmental

KW - Intracellular Signaling Peptides and Proteins

KW - Kidney

KW - Mesoderm

KW - Morphogenesis

KW - Nephrons

KW - Organ Culture Techniques

KW - Protein-Serine-Threonine Kinases

KW - Rats

KW - Rats, Sprague-Dawley

KW - Ureter

KW - rho-Associated Kinases

U2 - 10.1111/j.1432-0436.2006.00102.x

DO - 10.1111/j.1432-0436.2006.00102.x

M3 - SCORING: Journal article

C2 - 17177859

VL - 74

SP - 638

EP - 647

IS - 9-10

ER -