Revisiting AMPylation through the lens of Fic enzymes
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Revisiting AMPylation through the lens of Fic enzymes. / Gulen, Burak; Itzen, Aymelt.
In: TRENDS MICROBIOL, Vol. 30, No. 4, 04.2022, p. 350-363.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Revisiting AMPylation through the lens of Fic enzymes
AU - Gulen, Burak
AU - Itzen, Aymelt
N1 - Copyright © 2021 Elsevier Ltd. All rights reserved.
PY - 2022/4
Y1 - 2022/4
N2 - AMPylation, a post-translational modification (PTM) first discovered in the late 1960s, is catalyzed by adenosine monophosphate (AMP)-transferring enzymes. The observation that filamentation-induced-by-cyclic-AMP (fic) enzymes are associated with this unique PTM revealed that AMPylation plays a major role in hijacking of host signaling by pathogenic bacteria during infection. Studies over the past decade showed that AMPylation is conserved across all kingdoms of life and, outside their role in infection, also modulates cellular functions. Many aspects of AMPylation are yet to be uncovered. In this review we present the advancement in research on AMPylation and Fic enzymes as well as other distinct classes of enzymes that catalyze AMPylation.
AB - AMPylation, a post-translational modification (PTM) first discovered in the late 1960s, is catalyzed by adenosine monophosphate (AMP)-transferring enzymes. The observation that filamentation-induced-by-cyclic-AMP (fic) enzymes are associated with this unique PTM revealed that AMPylation plays a major role in hijacking of host signaling by pathogenic bacteria during infection. Studies over the past decade showed that AMPylation is conserved across all kingdoms of life and, outside their role in infection, also modulates cellular functions. Many aspects of AMPylation are yet to be uncovered. In this review we present the advancement in research on AMPylation and Fic enzymes as well as other distinct classes of enzymes that catalyze AMPylation.
U2 - 10.1016/j.tim.2021.08.003
DO - 10.1016/j.tim.2021.08.003
M3 - SCORING: Review article
C2 - 34531089
VL - 30
SP - 350
EP - 363
JO - TRENDS MICROBIOL
JF - TRENDS MICROBIOL
SN - 0966-842X
IS - 4
ER -