Revised histopathological consensus classification of joint implant related pathology

V Krenn; L Morawietz; G Perino; H Kienapfel; R Ascherl; G J Hassenpflug; M Thomsen; P Thomas; M Huber; D Kendoff; D Baumhoer; M G Krukemeyer; S Natu; F Boettner; Josef Zustin; B Kölbel; Wolfgang Ruether; J P Kretzer; A Tiemann; A Trampuz; L Frommelt; R Tichilow; S Söder; S Müller; J Parvizi; U Illgner; T Gehrke

doi:10.1016/j.prp.2014.09.017

Revised histopathological consensus classification of joint implant related pathology

Standard

Revised histopathological consensus classification of joint implant related pathology. / Krenn, V; Morawietz, L; Perino, G; Kienapfel, H; Ascherl, R; Hassenpflug, G J; Thomsen, M; Thomas, P; Huber, M; Kendoff, D; Baumhoer, D; Krukemeyer, M G; Natu, S; Boettner, F; Zustin, Josef; Kölbel, B; Ruether, Wolfgang; Kretzer, J P; Tiemann, A; Trampuz, A; Frommelt, L; Tichilow, R; Söder, S; Müller, S; Parvizi, J; Illgner, U; Gehrke, T.

In: PATHOL RES PRACT, Vol. 210, No. 12, 01.12.2014, p. 779-86.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Krenn, V, Morawietz, L, Perino, G, Kienapfel, H, Ascherl, R, Hassenpflug, GJ, Thomsen, M, Thomas, P, Huber, M, Kendoff, D, Baumhoer, D, Krukemeyer, MG, Natu, S, Boettner, F, Zustin, J, Kölbel, B, Ruether, W, Kretzer, JP, Tiemann, A, Trampuz, A, Frommelt, L, Tichilow, R, Söder, S, Müller, S, Parvizi, J, Illgner, U & Gehrke, T 2014, 'Revised histopathological consensus classification of joint implant related pathology', PATHOL RES PRACT, vol. 210, no. 12, pp. 779-86. https://doi.org/10.1016/j.prp.2014.09.017

APA

Krenn, V., Morawietz, L., Perino, G., Kienapfel, H., Ascherl, R., Hassenpflug, G. J., Thomsen, M., Thomas, P., Huber, M., Kendoff, D., Baumhoer, D., Krukemeyer, M. G., Natu, S., Boettner, F., Zustin, J., Kölbel, B., Ruether, W., Kretzer, J. P., Tiemann, A., ... Gehrke, T. (2014). Revised histopathological consensus classification of joint implant related pathology. PATHOL RES PRACT, 210(12), 779-86. https://doi.org/10.1016/j.prp.2014.09.017

Vancouver

Krenn V, Morawietz L, Perino G, Kienapfel H, Ascherl R, Hassenpflug GJ et al. Revised histopathological consensus classification of joint implant related pathology. PATHOL RES PRACT. 2014 Dec 1;210(12):779-86. https://doi.org/10.1016/j.prp.2014.09.017

Bibtex

@article{89c16a820102424c9f36b24b93ac709a,

title = "Revised histopathological consensus classification of joint implant related pathology",

abstract = "This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues. These changes may occur as a consequence of endoprosthetic replacement of large joints and may lead to a reduction in the prosthesis survival rate. We describe the established consensus classification of the periprosthetic membrane, in which aseptic and septic prosthetic loosening can be subdivided into four histological types, as well as histopathological criteria for additional significant pathologies including endoprosthetic-associated arthrofibrosis, particle-induced immunological, inflammatory and toxic mechanisms (adverse reactions), and bone tissue pathologies. These characteristic tissue alterations and their relationships are summarized in the extended classification. Since particle heterogeneity in periprosthetic tissue is high and particle identification is a necessary part of diagnosis, the identification of different types of particles is described in the histopathological particle algorithm. The morphological qualities of prosthetic material particles and the demarcation between abrasion and non-abrasion endogenous particles are also summarized. This feasible classification which is based on low cost standard tissue processing and examination and on well-defined diagnostic criteria is a solid platform for the histological diagnosis of implant associated pathologies providing a stable and reproducible tool for the surgical pathologist. Since this classification is suitable for standardized histopathological diagnostics, it might also provide a useful data set for joint arthroplasty registers, particularly for registers based on so-called routine data.",

author = "V Krenn and L Morawietz and G Perino and H Kienapfel and R Ascherl and Hassenpflug, {G J} and M Thomsen and P Thomas and M Huber and D Kendoff and D Baumhoer and Krukemeyer, {M G} and S Natu and F Boettner and Josef Zustin and B K{\"o}lbel and Wolfgang Ruether and Kretzer, {J P} and A Tiemann and A Trampuz and L Frommelt and R Tichilow and S S{\"o}der and S M{\"u}ller and J Parvizi and U Illgner and T Gehrke",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.prp.2014.09.017",

language = "English",

volume = "210",

pages = "779--86",

journal = "PATHOL RES PRACT",

issn = "0344-0338",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

number = "12",

}

RIS

TY - JOUR

T1 - Revised histopathological consensus classification of joint implant related pathology

AU - Krenn, V

AU - Morawietz, L

AU - Perino, G

AU - Kienapfel, H

AU - Ascherl, R

AU - Hassenpflug, G J

AU - Thomsen, M

AU - Thomas, P

AU - Huber, M

AU - Kendoff, D

AU - Baumhoer, D

AU - Krukemeyer, M G

AU - Natu, S

AU - Boettner, F

AU - Zustin, Josef

AU - Kölbel, B

AU - Ruether, Wolfgang

AU - Kretzer, J P

AU - Tiemann, A

AU - Trampuz, A

AU - Frommelt, L

AU - Tichilow, R

AU - Söder, S

AU - Müller, S

AU - Parvizi, J

AU - Illgner, U

AU - Gehrke, T

PY - 2014/12/1

Y1 - 2014/12/1

N2 - This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues. These changes may occur as a consequence of endoprosthetic replacement of large joints and may lead to a reduction in the prosthesis survival rate. We describe the established consensus classification of the periprosthetic membrane, in which aseptic and septic prosthetic loosening can be subdivided into four histological types, as well as histopathological criteria for additional significant pathologies including endoprosthetic-associated arthrofibrosis, particle-induced immunological, inflammatory and toxic mechanisms (adverse reactions), and bone tissue pathologies. These characteristic tissue alterations and their relationships are summarized in the extended classification. Since particle heterogeneity in periprosthetic tissue is high and particle identification is a necessary part of diagnosis, the identification of different types of particles is described in the histopathological particle algorithm. The morphological qualities of prosthetic material particles and the demarcation between abrasion and non-abrasion endogenous particles are also summarized. This feasible classification which is based on low cost standard tissue processing and examination and on well-defined diagnostic criteria is a solid platform for the histological diagnosis of implant associated pathologies providing a stable and reproducible tool for the surgical pathologist. Since this classification is suitable for standardized histopathological diagnostics, it might also provide a useful data set for joint arthroplasty registers, particularly for registers based on so-called routine data.

AB - This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues. These changes may occur as a consequence of endoprosthetic replacement of large joints and may lead to a reduction in the prosthesis survival rate. We describe the established consensus classification of the periprosthetic membrane, in which aseptic and septic prosthetic loosening can be subdivided into four histological types, as well as histopathological criteria for additional significant pathologies including endoprosthetic-associated arthrofibrosis, particle-induced immunological, inflammatory and toxic mechanisms (adverse reactions), and bone tissue pathologies. These characteristic tissue alterations and their relationships are summarized in the extended classification. Since particle heterogeneity in periprosthetic tissue is high and particle identification is a necessary part of diagnosis, the identification of different types of particles is described in the histopathological particle algorithm. The morphological qualities of prosthetic material particles and the demarcation between abrasion and non-abrasion endogenous particles are also summarized. This feasible classification which is based on low cost standard tissue processing and examination and on well-defined diagnostic criteria is a solid platform for the histological diagnosis of implant associated pathologies providing a stable and reproducible tool for the surgical pathologist. Since this classification is suitable for standardized histopathological diagnostics, it might also provide a useful data set for joint arthroplasty registers, particularly for registers based on so-called routine data.

U2 - 10.1016/j.prp.2014.09.017

DO - 10.1016/j.prp.2014.09.017

M3 - SCORING: Journal article

C2 - 25454771

VL - 210

SP - 779

EP - 786

JO - PATHOL RES PRACT

JF - PATHOL RES PRACT

SN - 0344-0338

IS - 12

ER -