Review on long-term non-renal complications of childhood nephrotic syndrome

Jiwon M Lee; Andreas Kronbichler; Jae Il Shin; Jun Oh

doi:10.1111/apa.15035

Review on long-term non-renal complications of childhood nephrotic syndrome

Standard

Review on long-term non-renal complications of childhood nephrotic syndrome. / Lee, Jiwon M; Kronbichler, Andreas; Shin, Jae Il; Oh, Jun.

In: ACTA PAEDIATR, Vol. 109, No. 3, 03.2020, p. 460-470.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Lee, JM, Kronbichler, A, Shin, JI & Oh, J 2020, 'Review on long-term non-renal complications of childhood nephrotic syndrome', ACTA PAEDIATR, vol. 109, no. 3, pp. 460-470. https://doi.org/10.1111/apa.15035

APA

Lee, J. M., Kronbichler, A., Shin, J. I., & Oh, J. (2020). Review on long-term non-renal complications of childhood nephrotic syndrome. ACTA PAEDIATR, 109(3), 460-470. https://doi.org/10.1111/apa.15035

Vancouver

Lee JM, Kronbichler A, Shin JI, Oh J. Review on long-term non-renal complications of childhood nephrotic syndrome. ACTA PAEDIATR. 2020 Mar;109(3):460-470. https://doi.org/10.1111/apa.15035

Bibtex

@article{bc4817399d82461483003c2704484c73,

title = "Review on long-term non-renal complications of childhood nephrotic syndrome",

abstract = "BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular childhood disease. A body of literature has described the long-term renal prognosis of childhood-onset idiopathic NS. However, the nonrenal outcomes have not been studied as much.AIM: We aimed to discuss the long-term non-renal outcomes of childhood NS, highlighting studies with a follow-up period of more than 10 years.RESULTS: We reviewed the literature and found that a number of immunosuppressive agents have stopped inflammation, stabilised the podocyte cytoskeleton and reduce proteinuria. However, prolonged treatment has frequently been associated with a high risk of renal and non-renal complications in patients with a complicated disease course, defined as frequent relapses or steroid dependency. Non-renal complications may include impaired longitudinal growth and pubertal development, undesirable fertility outcomes, ocular complications, bone mineral diseases and potential malignancies.CONCLUSION: This review discusses and summarises the non-renal outcomes of idiopathic childhood NS.",

author = "Lee, {Jiwon M} and Andreas Kronbichler and Shin, {Jae Il} and Jun Oh",

note = "{\textcopyright} 2019 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.",

year = "2020",

month = mar,

doi = "10.1111/apa.15035",

language = "English",

volume = "109",

pages = "460--470",

journal = "ACTA PAEDIATR",

issn = "0803-5253",

publisher = "Wiley-Blackwell",

number = "3",

}

RIS

TY - JOUR

T1 - Review on long-term non-renal complications of childhood nephrotic syndrome

AU - Lee, Jiwon M

AU - Kronbichler, Andreas

AU - Shin, Jae Il

AU - Oh, Jun

PY - 2020/3

Y1 - 2020/3

N2 - BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular childhood disease. A body of literature has described the long-term renal prognosis of childhood-onset idiopathic NS. However, the nonrenal outcomes have not been studied as much.AIM: We aimed to discuss the long-term non-renal outcomes of childhood NS, highlighting studies with a follow-up period of more than 10 years.RESULTS: We reviewed the literature and found that a number of immunosuppressive agents have stopped inflammation, stabilised the podocyte cytoskeleton and reduce proteinuria. However, prolonged treatment has frequently been associated with a high risk of renal and non-renal complications in patients with a complicated disease course, defined as frequent relapses or steroid dependency. Non-renal complications may include impaired longitudinal growth and pubertal development, undesirable fertility outcomes, ocular complications, bone mineral diseases and potential malignancies.CONCLUSION: This review discusses and summarises the non-renal outcomes of idiopathic childhood NS.

AB - BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular childhood disease. A body of literature has described the long-term renal prognosis of childhood-onset idiopathic NS. However, the nonrenal outcomes have not been studied as much.AIM: We aimed to discuss the long-term non-renal outcomes of childhood NS, highlighting studies with a follow-up period of more than 10 years.RESULTS: We reviewed the literature and found that a number of immunosuppressive agents have stopped inflammation, stabilised the podocyte cytoskeleton and reduce proteinuria. However, prolonged treatment has frequently been associated with a high risk of renal and non-renal complications in patients with a complicated disease course, defined as frequent relapses or steroid dependency. Non-renal complications may include impaired longitudinal growth and pubertal development, undesirable fertility outcomes, ocular complications, bone mineral diseases and potential malignancies.CONCLUSION: This review discusses and summarises the non-renal outcomes of idiopathic childhood NS.

U2 - 10.1111/apa.15035

DO - 10.1111/apa.15035

M3 - SCORING: Review article

C2 - 31561270

VL - 109

SP - 460

EP - 470

JO - ACTA PAEDIATR

JF - ACTA PAEDIATR

SN - 0803-5253

IS - 3

ER -