Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients.
Standard
Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients. / Nashan, Björn; Gaston, Robert; Emery, Vincent; Säemann, Marcus D; Mueller, Nicolas J; Couzi, Lionel; Dantal, Jacques; Shihab, Fuad; Mulgaonkar, Shamkant; Yu, Seun Kim; Brennan, Daniel C.
In: TRANSPLANTATION, Vol. 93, No. 11, 11, 2012, p. 1075-1085.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients.
AU - Nashan, Björn
AU - Gaston, Robert
AU - Emery, Vincent
AU - Säemann, Marcus D
AU - Mueller, Nicolas J
AU - Couzi, Lionel
AU - Dantal, Jacques
AU - Shihab, Fuad
AU - Mulgaonkar, Shamkant
AU - Yu, Seun Kim
AU - Brennan, Daniel C
PY - 2012
Y1 - 2012
N2 - Cytomegalovirus (CMV) infection and disease are major complications in the renal transplant recipient. The occurrence of CMV is associated with acute rejection, allograft dysfunction, significant end-organ disease, and mortality. Several clinical studies have indicated that the use of certain immunosuppressive drugs can delay the reconstitution of CMV-specific cell-mediated immune responses, thereby leading to uncontrolled CMV replication. Accumulating evidence indicates, however, that the use of the mammalian target of rapamycin (mTOR) inhibitors, sirolimus, and everolimus, may decrease the incidence and severity of CMV infection in renal transplant recipients. The purpose of this article is to review CMV infection data from randomized clinical trials that investigated the use of sirolimus- and everolimus-based treatment regimens in de novo renal transplantation. The mTOR inhibitor clinical trials included were primarily identified using biomedical literature database searches, with additional studies added at the authors' discretion. This review will summarize these studies to discuss whether mTOR inhibitor-based immunosuppressive therapy can reduce the magnitude of CMV-related complications in the de novo renal transplantation setting.
AB - Cytomegalovirus (CMV) infection and disease are major complications in the renal transplant recipient. The occurrence of CMV is associated with acute rejection, allograft dysfunction, significant end-organ disease, and mortality. Several clinical studies have indicated that the use of certain immunosuppressive drugs can delay the reconstitution of CMV-specific cell-mediated immune responses, thereby leading to uncontrolled CMV replication. Accumulating evidence indicates, however, that the use of the mammalian target of rapamycin (mTOR) inhibitors, sirolimus, and everolimus, may decrease the incidence and severity of CMV infection in renal transplant recipients. The purpose of this article is to review CMV infection data from randomized clinical trials that investigated the use of sirolimus- and everolimus-based treatment regimens in de novo renal transplantation. The mTOR inhibitor clinical trials included were primarily identified using biomedical literature database searches, with additional studies added at the authors' discretion. This review will summarize these studies to discuss whether mTOR inhibitor-based immunosuppressive therapy can reduce the magnitude of CMV-related complications in the de novo renal transplantation setting.
KW - Humans
KW - Kidney Transplantation
KW - Cytomegalovirus/drug effects
KW - Cytomegalovirus Infections/etiology/prevention & control
KW - Immunosuppressive Agents/pharmacology/therapeutic use
KW - Postoperative Complications/prevention & control
KW - Sirolimus/analogs & derivatives/pharmacology/therapeutic use
KW - Humans
KW - Kidney Transplantation
KW - Cytomegalovirus/drug effects
KW - Cytomegalovirus Infections/etiology/prevention & control
KW - Immunosuppressive Agents/pharmacology/therapeutic use
KW - Postoperative Complications/prevention & control
KW - Sirolimus/analogs & derivatives/pharmacology/therapeutic use
M3 - SCORING: Journal article
VL - 93
SP - 1075
EP - 1085
JO - TRANSPLANTATION
JF - TRANSPLANTATION
SN - 0041-1337
IS - 11
M1 - 11
ER -