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Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study

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Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study. / Feltgen, Nicolas; Ach, Thomas; Ziemssen, Focke; Quante, Carolin Sophie; Gross, Oliver; Abdin, Alaa Din; Aisenbrey, Sabine; Bartram, Martin C; Blum, Marcus; Brockmann, Claudia; Dithmar, Stefan; Friedrichs, Wilko; Guthoff, Rainer; Hattenbach, Lars-Olof; Herrlinger, Klaus R; Kaskel-Paul, Susanne; Khoramnia, Ramin; Klaas, Julian E; Krohne, Tim U; Lommatzsch, Albrecht; Lueken, Sabine; Maier, Mathias; Nassri, Lina; Nguyen-Dang, Thien A; Radeck, Viola; Rau, Saskia; Roider, Johann; Sandner, Dirk; Schmalenberger, Laura; Schmidtmann, Irene; Schubert, Florian; Siegel, Helena; Spitzer, Martin S; Stahl, Andreas; Stingl, Julia V; Treumer, Felix; Viestenz, Arne; Wachtlin, Joachim; Wolf, Armin; Zimmermann, Julian; Schargus, Marc; Schuster, Alexander K.

In: J CLIN MED, Vol. 11, No. 17, 5101, 30.08.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Feltgen, N, Ach, T, Ziemssen, F, Quante, CS, Gross, O, Abdin, AD, Aisenbrey, S, Bartram, MC, Blum, M, Brockmann, C, Dithmar, S, Friedrichs, W, Guthoff, R, Hattenbach, L-O, Herrlinger, KR, Kaskel-Paul, S, Khoramnia, R, Klaas, JE, Krohne, TU, Lommatzsch, A, Lueken, S, Maier, M, Nassri, L, Nguyen-Dang, TA, Radeck, V, Rau, S, Roider, J, Sandner, D, Schmalenberger, L, Schmidtmann, I, Schubert, F, Siegel, H, Spitzer, MS, Stahl, A, Stingl, JV, Treumer, F, Viestenz, A, Wachtlin, J, Wolf, A, Zimmermann, J, Schargus, M & Schuster, AK 2022, 'Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study', J CLIN MED, vol. 11, no. 17, 5101. https://doi.org/10.3390/jcm11175101

APA

Feltgen, N., Ach, T., Ziemssen, F., Quante, C. S., Gross, O., Abdin, A. D., Aisenbrey, S., Bartram, M. C., Blum, M., Brockmann, C., Dithmar, S., Friedrichs, W., Guthoff, R., Hattenbach, L-O., Herrlinger, K. R., Kaskel-Paul, S., Khoramnia, R., Klaas, J. E., Krohne, T. U., ... Schuster, A. K. (2022). Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study. J CLIN MED, 11(17), [5101]. https://doi.org/10.3390/jcm11175101

Vancouver

Feltgen N, Ach T, Ziemssen F, Quante CS, Gross O, Abdin AD et al. Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study. J CLIN MED. 2022 Aug 30;11(17). 5101. https://doi.org/10.3390/jcm11175101

Bibtex

@article{3b7d50aa12c14626a031891e161a37d5,
title = "Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study",
abstract = "BACKGROUND: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD).METHODS: In this multicentre study, data from patients with central and branch retinal vein occlusion (CRVO and BRVO), central and branch retinal artery occlusion (CRAO and BRAO), and anterior ischaemic optic neuropathy (AION) were retrospectively collected during a 2-month index period (1 June-31 July 2021) according to a defined protocol. The relation to any previous vaccination was documented for the consecutive case series. Numbers of RVOD and COVID-19 vaccination were investigated in a case-by-case analysis. A case-control study using age- and sex-matched controls from the general population (study participants from the Gutenberg Health Study) and an adjusted conditional logistic regression analysis was conducted.RESULTS: Four hundred and twenty-one subjects presenting during the index period (61 days) were enrolled: one hundred and twenty-one patients with CRVO, seventy-five with BRVO, fifty-six with CRAO, sixty-five with BRAO, and one hundred and four with AION. Three hundred and thirty-two (78.9%) patients had been vaccinated before the onset of RVOD. The vaccines given were BNT162b2/BioNTech/Pfizer (n = 221), followed by ChadOx1/AstraZeneca (n = 57), mRNA-1273/Moderna (n = 21), and Ad26.COV2.S/Johnson & Johnson (n = 11; unknown n = 22). Our case-control analysis integrating population-based data from the GHS yielded no evidence of an increased risk after COVID-19 vaccination (OR = 0.93; 95% CI: 0.60-1.45, p = 0.75) in connection with a vaccination within a 4-week window.CONCLUSIONS: To date, there has been no evidence of any association between SARS-CoV-2 vaccination and a higher RVOD risk.",
author = "Nicolas Feltgen and Thomas Ach and Focke Ziemssen and Quante, {Carolin Sophie} and Oliver Gross and Abdin, {Alaa Din} and Sabine Aisenbrey and Bartram, {Martin C} and Marcus Blum and Claudia Brockmann and Stefan Dithmar and Wilko Friedrichs and Rainer Guthoff and Lars-Olof Hattenbach and Herrlinger, {Klaus R} and Susanne Kaskel-Paul and Ramin Khoramnia and Klaas, {Julian E} and Krohne, {Tim U} and Albrecht Lommatzsch and Sabine Lueken and Mathias Maier and Lina Nassri and Nguyen-Dang, {Thien A} and Viola Radeck and Saskia Rau and Johann Roider and Dirk Sandner and Laura Schmalenberger and Irene Schmidtmann and Florian Schubert and Helena Siegel and Spitzer, {Martin S} and Andreas Stahl and Stingl, {Julia V} and Felix Treumer and Arne Viestenz and Joachim Wachtlin and Armin Wolf and Julian Zimmermann and Marc Schargus and Schuster, {Alexander K}",
year = "2022",
month = aug,
day = "30",
doi = "10.3390/jcm11175101",
language = "English",
volume = "11",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "17",

}

RIS

TY - JOUR

T1 - Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study

AU - Feltgen, Nicolas

AU - Ach, Thomas

AU - Ziemssen, Focke

AU - Quante, Carolin Sophie

AU - Gross, Oliver

AU - Abdin, Alaa Din

AU - Aisenbrey, Sabine

AU - Bartram, Martin C

AU - Blum, Marcus

AU - Brockmann, Claudia

AU - Dithmar, Stefan

AU - Friedrichs, Wilko

AU - Guthoff, Rainer

AU - Hattenbach, Lars-Olof

AU - Herrlinger, Klaus R

AU - Kaskel-Paul, Susanne

AU - Khoramnia, Ramin

AU - Klaas, Julian E

AU - Krohne, Tim U

AU - Lommatzsch, Albrecht

AU - Lueken, Sabine

AU - Maier, Mathias

AU - Nassri, Lina

AU - Nguyen-Dang, Thien A

AU - Radeck, Viola

AU - Rau, Saskia

AU - Roider, Johann

AU - Sandner, Dirk

AU - Schmalenberger, Laura

AU - Schmidtmann, Irene

AU - Schubert, Florian

AU - Siegel, Helena

AU - Spitzer, Martin S

AU - Stahl, Andreas

AU - Stingl, Julia V

AU - Treumer, Felix

AU - Viestenz, Arne

AU - Wachtlin, Joachim

AU - Wolf, Armin

AU - Zimmermann, Julian

AU - Schargus, Marc

AU - Schuster, Alexander K

PY - 2022/8/30

Y1 - 2022/8/30

N2 - BACKGROUND: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD).METHODS: In this multicentre study, data from patients with central and branch retinal vein occlusion (CRVO and BRVO), central and branch retinal artery occlusion (CRAO and BRAO), and anterior ischaemic optic neuropathy (AION) were retrospectively collected during a 2-month index period (1 June-31 July 2021) according to a defined protocol. The relation to any previous vaccination was documented for the consecutive case series. Numbers of RVOD and COVID-19 vaccination were investigated in a case-by-case analysis. A case-control study using age- and sex-matched controls from the general population (study participants from the Gutenberg Health Study) and an adjusted conditional logistic regression analysis was conducted.RESULTS: Four hundred and twenty-one subjects presenting during the index period (61 days) were enrolled: one hundred and twenty-one patients with CRVO, seventy-five with BRVO, fifty-six with CRAO, sixty-five with BRAO, and one hundred and four with AION. Three hundred and thirty-two (78.9%) patients had been vaccinated before the onset of RVOD. The vaccines given were BNT162b2/BioNTech/Pfizer (n = 221), followed by ChadOx1/AstraZeneca (n = 57), mRNA-1273/Moderna (n = 21), and Ad26.COV2.S/Johnson & Johnson (n = 11; unknown n = 22). Our case-control analysis integrating population-based data from the GHS yielded no evidence of an increased risk after COVID-19 vaccination (OR = 0.93; 95% CI: 0.60-1.45, p = 0.75) in connection with a vaccination within a 4-week window.CONCLUSIONS: To date, there has been no evidence of any association between SARS-CoV-2 vaccination and a higher RVOD risk.

AB - BACKGROUND: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD).METHODS: In this multicentre study, data from patients with central and branch retinal vein occlusion (CRVO and BRVO), central and branch retinal artery occlusion (CRAO and BRAO), and anterior ischaemic optic neuropathy (AION) were retrospectively collected during a 2-month index period (1 June-31 July 2021) according to a defined protocol. The relation to any previous vaccination was documented for the consecutive case series. Numbers of RVOD and COVID-19 vaccination were investigated in a case-by-case analysis. A case-control study using age- and sex-matched controls from the general population (study participants from the Gutenberg Health Study) and an adjusted conditional logistic regression analysis was conducted.RESULTS: Four hundred and twenty-one subjects presenting during the index period (61 days) were enrolled: one hundred and twenty-one patients with CRVO, seventy-five with BRVO, fifty-six with CRAO, sixty-five with BRAO, and one hundred and four with AION. Three hundred and thirty-two (78.9%) patients had been vaccinated before the onset of RVOD. The vaccines given were BNT162b2/BioNTech/Pfizer (n = 221), followed by ChadOx1/AstraZeneca (n = 57), mRNA-1273/Moderna (n = 21), and Ad26.COV2.S/Johnson & Johnson (n = 11; unknown n = 22). Our case-control analysis integrating population-based data from the GHS yielded no evidence of an increased risk after COVID-19 vaccination (OR = 0.93; 95% CI: 0.60-1.45, p = 0.75) in connection with a vaccination within a 4-week window.CONCLUSIONS: To date, there has been no evidence of any association between SARS-CoV-2 vaccination and a higher RVOD risk.

U2 - 10.3390/jcm11175101

DO - 10.3390/jcm11175101

M3 - SCORING: Journal article

C2 - 36079030

VL - 11

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 17

M1 - 5101

ER -