Research ExplorerPublicationsResting energy expenditure and substrate oxidation rates cor...

Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest- a prospective observational cohort study

Standard

Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest- a prospective observational cohort study. / Holzinger, Ulrike; Brunner, Richard; Losert, Heidrun; Fuhrmann, Valentin; Herkner, Harald; Madl, Christian; Sterz, Fritz; Schneeweiß, Bruno.

In: CRIT CARE, Vol. 19, No. 1, 29.03.2015, p. 128.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Holzinger, U, Brunner, R, Losert, H, Fuhrmann, V, Herkner, H, Madl, C, Sterz, F & Schneeweiß, B 2015, 'Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest- a prospective observational cohort study', CRIT CARE, vol. 19, no. 1, pp. 128. https://doi.org/10.1186/s13054-015-0856-2

APA

Holzinger, U., Brunner, R., Losert, H., Fuhrmann, V., Herkner, H., Madl, C., Sterz, F., & Schneeweiß, B. (2015). Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest- a prospective observational cohort study. CRIT CARE, 19(1), 128. https://doi.org/10.1186/s13054-015-0856-2

Vancouver

Holzinger U, Brunner R, Losert H, Fuhrmann V, Herkner H, Madl C et al. Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest- a prospective observational cohort study. CRIT CARE. 2015 Mar 29;19(1):128. https://doi.org/10.1186/s13054-015-0856-2

Bibtex

@article{98c90108ccd8452f8ecf93bd526d3755,
title = "Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest- a prospective observational cohort study",
abstract = "INTRODUCTION: Targeted temperature management improves outcome after cardiopulmonary resuscitation. Reduction of resting energy expenditure might be one mode of action. Aim of this study was to correlate resting energy expenditure and substrate oxidation rates with targeted temperature management at 33°C and outcome in patients after cardiac arrest.METHODS: This prospective, observational cohort study was performed at the department of emergency medicine and a medical intensive care unit of a university hospital. Patients after successful cardiopulmonary resuscitation undergoing targeted temperature management at 33°C for 24 hours with subsequent rewarming to 36°C and standardized sedation, analgesic and paralytic medication were included. Indirect calorimetry was performed 5 times within 48 h after cardiac arrest. Measurements were correlated to outcome with repeated measures ANOVA, linear and logistic regression analysis.RESULTS: In 25 patients resting energy expenditure decreased 20 (18-27) % at 33°C compared to 36°C without differences between outcome groups (favourable vs. unfavourable: 25 (21-26) vs. 21 (16-26); p = 0.5). In contrast to protein oxidation rate (favourable vs. unfavourable: 35 (11-68) g/day vs. 39 (7-75) g/day, p = 0.8) patients with favourable outcome had a significantly higher fat oxidation rate (139 (104-171) g/day vs. 117 (70-139) g/day, p < 0.05) and a significantly lower glucose oxidation rate (30 (-34-88) g/day vs. 77 (19-138) g/day; p < 0.05) as compared to patients with unfavourable neurological outcome.CONCLUSIONS: Targeted temperature management at 33°C after cardiac arrest reduces REE by 20% compared to 36°C. Glucose and fat oxidation rates differ significantly between patients with favourable and unfavourable neurological outcome.TRIAL REGISTRATION: Clinicaltrials.gov NCT00500825 . Registered 11 July 2007.",
author = "Ulrike Holzinger and Richard Brunner and Heidrun Losert and Valentin Fuhrmann and Harald Herkner and Christian Madl and Fritz Sterz and Bruno Schneewei{\ss}",
year = "2015",
month = mar,
day = "29",
doi = "10.1186/s13054-015-0856-2",
language = "English",
volume = "19",
pages = "128",
journal = "CRIT CARE",
issn = "1364-8535",
publisher = "Springer Science + Business Media",
number = "1",

}

RIS

TY - JOUR

T1 - Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest- a prospective observational cohort study

AU - Holzinger, Ulrike

AU - Brunner, Richard

AU - Losert, Heidrun

AU - Fuhrmann, Valentin

AU - Herkner, Harald

AU - Madl, Christian

AU - Sterz, Fritz

AU - Schneeweiß, Bruno

PY - 2015/3/29

Y1 - 2015/3/29

N2 - INTRODUCTION: Targeted temperature management improves outcome after cardiopulmonary resuscitation. Reduction of resting energy expenditure might be one mode of action. Aim of this study was to correlate resting energy expenditure and substrate oxidation rates with targeted temperature management at 33°C and outcome in patients after cardiac arrest.METHODS: This prospective, observational cohort study was performed at the department of emergency medicine and a medical intensive care unit of a university hospital. Patients after successful cardiopulmonary resuscitation undergoing targeted temperature management at 33°C for 24 hours with subsequent rewarming to 36°C and standardized sedation, analgesic and paralytic medication were included. Indirect calorimetry was performed 5 times within 48 h after cardiac arrest. Measurements were correlated to outcome with repeated measures ANOVA, linear and logistic regression analysis.RESULTS: In 25 patients resting energy expenditure decreased 20 (18-27) % at 33°C compared to 36°C without differences between outcome groups (favourable vs. unfavourable: 25 (21-26) vs. 21 (16-26); p = 0.5). In contrast to protein oxidation rate (favourable vs. unfavourable: 35 (11-68) g/day vs. 39 (7-75) g/day, p = 0.8) patients with favourable outcome had a significantly higher fat oxidation rate (139 (104-171) g/day vs. 117 (70-139) g/day, p < 0.05) and a significantly lower glucose oxidation rate (30 (-34-88) g/day vs. 77 (19-138) g/day; p < 0.05) as compared to patients with unfavourable neurological outcome.CONCLUSIONS: Targeted temperature management at 33°C after cardiac arrest reduces REE by 20% compared to 36°C. Glucose and fat oxidation rates differ significantly between patients with favourable and unfavourable neurological outcome.TRIAL REGISTRATION: Clinicaltrials.gov NCT00500825 . Registered 11 July 2007.

AB - INTRODUCTION: Targeted temperature management improves outcome after cardiopulmonary resuscitation. Reduction of resting energy expenditure might be one mode of action. Aim of this study was to correlate resting energy expenditure and substrate oxidation rates with targeted temperature management at 33°C and outcome in patients after cardiac arrest.METHODS: This prospective, observational cohort study was performed at the department of emergency medicine and a medical intensive care unit of a university hospital. Patients after successful cardiopulmonary resuscitation undergoing targeted temperature management at 33°C for 24 hours with subsequent rewarming to 36°C and standardized sedation, analgesic and paralytic medication were included. Indirect calorimetry was performed 5 times within 48 h after cardiac arrest. Measurements were correlated to outcome with repeated measures ANOVA, linear and logistic regression analysis.RESULTS: In 25 patients resting energy expenditure decreased 20 (18-27) % at 33°C compared to 36°C without differences between outcome groups (favourable vs. unfavourable: 25 (21-26) vs. 21 (16-26); p = 0.5). In contrast to protein oxidation rate (favourable vs. unfavourable: 35 (11-68) g/day vs. 39 (7-75) g/day, p = 0.8) patients with favourable outcome had a significantly higher fat oxidation rate (139 (104-171) g/day vs. 117 (70-139) g/day, p < 0.05) and a significantly lower glucose oxidation rate (30 (-34-88) g/day vs. 77 (19-138) g/day; p < 0.05) as compared to patients with unfavourable neurological outcome.CONCLUSIONS: Targeted temperature management at 33°C after cardiac arrest reduces REE by 20% compared to 36°C. Glucose and fat oxidation rates differ significantly between patients with favourable and unfavourable neurological outcome.TRIAL REGISTRATION: Clinicaltrials.gov NCT00500825 . Registered 11 July 2007.

U2 - 10.1186/s13054-015-0856-2

DO - 10.1186/s13054-015-0856-2

M3 - SCORING: Journal article

C2 - 25888299

VL - 19

SP - 128

JO - CRIT CARE

JF - CRIT CARE

SN - 1364-8535

IS - 1

ER -