Responsiveness of the PHQ-9 to Psychopharmacological Depression Treatment.
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Responsiveness of the PHQ-9 to Psychopharmacological Depression Treatment. / Löwe, Bernd; Schenkel, Irini; Carney-Doebbeling, Caroline; Göbel, Claus.
In: PSYCHOSOMATICS, Vol. 47, No. 1, 1, 2006, p. 62-67.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Responsiveness of the PHQ-9 to Psychopharmacological Depression Treatment.
AU - Löwe, Bernd
AU - Schenkel, Irini
AU - Carney-Doebbeling, Caroline
AU - Göbel, Claus
PY - 2006
Y1 - 2006
N2 - This is the first study that investigates the responsiveness of the Patient Health Questionnaire-9 (PHQ-9), a standard 9-item self-report depression scale, to antidepressant medication. Authors analyzed data from 1,788 depressed outpatients (66.8% women; mean age, 50.3 years), participating in a prospective, open-label, non-interventional, observational study of sertraline. On the 0-27-point PHQ-9 scale, the total sample gained 10.3 points at 12 weeks, corresponding to a standardized effect size of -1.85. With reference to two independent criterion standards, the PHQ-9 change scores were considerably greater in therapy responders than in nonresponders. The PHQ-9 was equally responsive in men and women. Therefore, the PHQ-9 qualifies as a practical tool for gauging response to pharmacological treatment in depressed patients.
AB - This is the first study that investigates the responsiveness of the Patient Health Questionnaire-9 (PHQ-9), a standard 9-item self-report depression scale, to antidepressant medication. Authors analyzed data from 1,788 depressed outpatients (66.8% women; mean age, 50.3 years), participating in a prospective, open-label, non-interventional, observational study of sertraline. On the 0-27-point PHQ-9 scale, the total sample gained 10.3 points at 12 weeks, corresponding to a standardized effect size of -1.85. With reference to two independent criterion standards, the PHQ-9 change scores were considerably greater in therapy responders than in nonresponders. The PHQ-9 was equally responsive in men and women. Therefore, the PHQ-9 qualifies as a practical tool for gauging response to pharmacological treatment in depressed patients.
M3 - SCORING: Zeitschriftenaufsatz
VL - 47
SP - 62
EP - 67
JO - PSYCHOSOMATICS
JF - PSYCHOSOMATICS
SN - 0033-3182
IS - 1
M1 - 1
ER -
