Respiratory response of malignant and placental cells to changes in oxygen concentration.
Standard
Respiratory response of malignant and placental cells to changes in oxygen concentration. / Garedew, Assegid; Kämmerer, Ulrike; Singer, Dominique.
In: RESP PHYSIOL NEUROBI, Vol. 165, No. 2-3, 2-3, 2009, p. 154-160.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Respiratory response of malignant and placental cells to changes in oxygen concentration.
AU - Garedew, Assegid
AU - Kämmerer, Ulrike
AU - Singer, Dominique
PY - 2009
Y1 - 2009
N2 - Malignant cells and foetal tissues are exposed to low oxygen partial pressure (pO2) in situ due to the limited supply of oxygenated blood. Whether these cells have adapted to low pO2 or live under constant constraint is not clear. Herein, we compared the respiratory responses of different malignant cell types, maternal and foetal placental leucocytes, and benign cells by incubating them under a gradient of pO2, from saturation to hypoxia, in a high resolution respirometer. The malignant cells and foetal leucocytes showed higher rates of mitochondrial oxygen uptake compared to the benign cells and maternal leucocytes, respectively. On the other hand, the mitochondrial oxygen uptake rates of the hypoxia adapted cells declined faster than the other cell types during the onset of hypoxia, probably suggesting conformance of aerobic metabolism to the local oxygen concentration. The O2 consumption rate per million cells (JO2) of the malignant cells declined only when the O2 concentration ([O2]) decreased to values
AB - Malignant cells and foetal tissues are exposed to low oxygen partial pressure (pO2) in situ due to the limited supply of oxygenated blood. Whether these cells have adapted to low pO2 or live under constant constraint is not clear. Herein, we compared the respiratory responses of different malignant cell types, maternal and foetal placental leucocytes, and benign cells by incubating them under a gradient of pO2, from saturation to hypoxia, in a high resolution respirometer. The malignant cells and foetal leucocytes showed higher rates of mitochondrial oxygen uptake compared to the benign cells and maternal leucocytes, respectively. On the other hand, the mitochondrial oxygen uptake rates of the hypoxia adapted cells declined faster than the other cell types during the onset of hypoxia, probably suggesting conformance of aerobic metabolism to the local oxygen concentration. The O2 consumption rate per million cells (JO2) of the malignant cells declined only when the O2 concentration ([O2]) decreased to values
M3 - SCORING: Zeitschriftenaufsatz
VL - 165
SP - 154
EP - 160
JO - RESP PHYSIOL NEUROBI
JF - RESP PHYSIOL NEUROBI
SN - 1569-9048
IS - 2-3
M1 - 2-3
ER -
