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Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

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Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation. / Chu, Chung-Ching; Ali, Niwa; Karagiannis, Panagiotis; Di Meglio, Paola; Skowera, Ania; Napolitano, Luca; Barinaga, Guillermo; Grys, Katarzyna; Sharif-Paghaleh, Ehsan; Karagiannis, Sophia N; Peakman, Mark; Lombardi, Giovanna; Nestle, Frank O.

In: J EXP MED, Vol. 209, No. 5, 07.05.2012, p. 935-45.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chu, C-C, Ali, N, Karagiannis, P, Di Meglio, P, Skowera, A, Napolitano, L, Barinaga, G, Grys, K, Sharif-Paghaleh, E, Karagiannis, SN, Peakman, M, Lombardi, G & Nestle, FO 2012, 'Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation', J EXP MED, vol. 209, no. 5, pp. 935-45. https://doi.org/10.1084/jem.20112583

APA

Chu, C-C., Ali, N., Karagiannis, P., Di Meglio, P., Skowera, A., Napolitano, L., Barinaga, G., Grys, K., Sharif-Paghaleh, E., Karagiannis, S. N., Peakman, M., Lombardi, G., & Nestle, F. O. (2012). Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation. J EXP MED, 209(5), 935-45. https://doi.org/10.1084/jem.20112583

Vancouver

Chu C-C, Ali N, Karagiannis P, Di Meglio P, Skowera A, Napolitano L et al. Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation. J EXP MED. 2012 May 7;209(5):935-45. https://doi.org/10.1084/jem.20112583

Bibtex

@article{c52d6cba3eda4500b74b10c06bec3d47,
title = "Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation",
abstract = "Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood. In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs). CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation. Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs. These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity. These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity. Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.",
keywords = "Analysis of Variance, Animals, Antigens, Surface/metabolism, Cell- and Tissue-Based Therapy/methods, Cholecalciferol/pharmacology, Dermatitis/immunology, Female, Graft vs Host Disease/prevention & control, Homeostasis/immunology, Humans, Indoles, Interleukin Receptor Common gamma Subunit/genetics, Interleukin-10/immunology, Langerhans Cells/drug effects, Lipopolysaccharide Receptors/metabolism, Male, Mice, Mice, Inbred NOD, Mice, Knockout, Mice, SCID, T-Lymphocytes, Regulatory/immunology, Thrombomodulin",
author = "Chung-Ching Chu and Niwa Ali and Panagiotis Karagiannis and {Di Meglio}, Paola and Ania Skowera and Luca Napolitano and Guillermo Barinaga and Katarzyna Grys and Ehsan Sharif-Paghaleh and Karagiannis, {Sophia N} and Mark Peakman and Giovanna Lombardi and Nestle, {Frank O}",
year = "2012",
month = may,
day = "7",
doi = "10.1084/jem.20112583",
language = "English",
volume = "209",
pages = "935--45",
journal = "J EXP MED",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

AU - Chu, Chung-Ching

AU - Ali, Niwa

AU - Karagiannis, Panagiotis

AU - Di Meglio, Paola

AU - Skowera, Ania

AU - Napolitano, Luca

AU - Barinaga, Guillermo

AU - Grys, Katarzyna

AU - Sharif-Paghaleh, Ehsan

AU - Karagiannis, Sophia N

AU - Peakman, Mark

AU - Lombardi, Giovanna

AU - Nestle, Frank O

PY - 2012/5/7

Y1 - 2012/5/7

N2 - Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood. In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs). CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation. Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs. These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity. These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity. Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.

AB - Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood. In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD14, and constitutive IL-10 secretion (CD141(+) DDCs). CD141(+) DDCs possess lymph node migratory capacity, induce T cell hyporesponsiveness, cross-present self-antigens to autoreactive T cells, and induce potent regulatory T cells that inhibit skin inflammation. Vitamin D(3) (VitD3) promotes certain phenotypic and functional properties of tissue-resident CD141(+) DDCs from human blood DCs. These CD141(+) DDC-like cells can be generated in vitro and, once transferred in vivo, have the capacity to inhibit xeno-graft versus host disease and tumor alloimmunity. These findings suggest that CD141(+) DDCs play an essential role in the maintenance of skin homeostasis and in the regulation of both systemic and tumor alloimmunity. Finally, VitD3-induced CD141(+) DDC-like cells have potential clinical use for their capacity to induce immune tolerance.

KW - Analysis of Variance

KW - Animals

KW - Antigens, Surface/metabolism

KW - Cell- and Tissue-Based Therapy/methods

KW - Cholecalciferol/pharmacology

KW - Dermatitis/immunology

KW - Female

KW - Graft vs Host Disease/prevention & control

KW - Homeostasis/immunology

KW - Humans

KW - Indoles

KW - Interleukin Receptor Common gamma Subunit/genetics

KW - Interleukin-10/immunology

KW - Langerhans Cells/drug effects

KW - Lipopolysaccharide Receptors/metabolism

KW - Male

KW - Mice

KW - Mice, Inbred NOD

KW - Mice, Knockout

KW - Mice, SCID

KW - T-Lymphocytes, Regulatory/immunology

KW - Thrombomodulin

U2 - 10.1084/jem.20112583

DO - 10.1084/jem.20112583

M3 - SCORING: Journal article

C2 - 22547651

VL - 209

SP - 935

EP - 945

JO - J EXP MED

JF - J EXP MED

SN - 0022-1007

IS - 5

ER -