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Resection margin clearance in pancreatic cancer after implementation of the Leeds Pathology Protocol (LEEPP): clinically relevant or just academic?

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Resection margin clearance in pancreatic cancer after implementation of the Leeds Pathology Protocol (LEEPP): clinically relevant or just academic? / Gebauer, Florian; Tachezy, Michael; Vashist, Yogesh K; Marx, Andreas H; Yekebas, Emre; Izbicki, Jakob R; Bockhorn, Maximilian.

In: WORLD J SURG, Vol. 39, No. 2, 02.2015, p. 493-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gebauer, F, Tachezy, M, Vashist, YK, Marx, AH, Yekebas, E, Izbicki, JR & Bockhorn, M 2015, 'Resection margin clearance in pancreatic cancer after implementation of the Leeds Pathology Protocol (LEEPP): clinically relevant or just academic?', WORLD J SURG, vol. 39, no. 2, pp. 493-9. https://doi.org/10.1007/s00268-014-2808-4

APA

Gebauer, F., Tachezy, M., Vashist, Y. K., Marx, A. H., Yekebas, E., Izbicki, J. R., & Bockhorn, M. (2015). Resection margin clearance in pancreatic cancer after implementation of the Leeds Pathology Protocol (LEEPP): clinically relevant or just academic? WORLD J SURG, 39(2), 493-9. https://doi.org/10.1007/s00268-014-2808-4

Vancouver

Gebauer F, Tachezy M, Vashist YK, Marx AH, Yekebas E, Izbicki JR et al. Resection margin clearance in pancreatic cancer after implementation of the Leeds Pathology Protocol (LEEPP): clinically relevant or just academic? WORLD J SURG. 2015 Feb;39(2):493-9. https://doi.org/10.1007/s00268-014-2808-4

Bibtex

@article{ebddf949308c404cb941513398c655ff,
title = "Resection margin clearance in pancreatic cancer after implementation of the Leeds Pathology Protocol (LEEPP): clinically relevant or just academic?",
abstract = "BACKGROUND AND OBJECTIVES: The aim of this study was to assess the overall survival (OS) after R0/R1 resections in patients with pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head after implementation of a standardized histopathologic protocol (Leeds Pathology Protocol, LEEPP).METHODS: One hundred and twenty-five patients underwent surgical resection because of PDAC of the pancreatic head. Patients were histopathologically examined according to a standardized protocol. Their oncologic outcome and clinicopathologic data were compared with those of a patient group before implementation of the LEEPP (n = 116).RESULTS: The R1 rate increased significantly from 13 to 52 %. There was no significant difference in OS between R0 and R1 resections. The median OS in patients with a tumor clearance of less than 2 mm from the resection margin was 15.1 months (12.1-18.1 months) versus 22.2 months (7.8-36.7 months) (P = 0.046). Multivariate analysis revealed a margin clearance or 2 mm and more as an independent prognosticator for OS.CONCLUSIONS: With applying the LEEPP, there was still no significant correlation between the R-status and OS in patients with PDAC. However, since a margin clearance of 2 mm or more is a predictive factor for OS, the R1 definition might have to be adapted in PDAC.",
keywords = "Adult, Aged, Aged, 80 and over, Carcinoma, Pancreatic Ductal, Female, Humans, Male, Middle Aged, Multivariate Analysis, Neoplasm, Residual, Pancreatic Neoplasms, Pancreaticoduodenectomy, Prospective Studies, Survival Rate",
author = "Florian Gebauer and Michael Tachezy and Vashist, {Yogesh K} and Marx, {Andreas H} and Emre Yekebas and Izbicki, {Jakob R} and Maximilian Bockhorn",
year = "2015",
month = feb,
doi = "10.1007/s00268-014-2808-4",
language = "English",
volume = "39",
pages = "493--9",
journal = "WORLD J SURG",
issn = "0364-2313",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Resection margin clearance in pancreatic cancer after implementation of the Leeds Pathology Protocol (LEEPP): clinically relevant or just academic?

AU - Gebauer, Florian

AU - Tachezy, Michael

AU - Vashist, Yogesh K

AU - Marx, Andreas H

AU - Yekebas, Emre

AU - Izbicki, Jakob R

AU - Bockhorn, Maximilian

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND AND OBJECTIVES: The aim of this study was to assess the overall survival (OS) after R0/R1 resections in patients with pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head after implementation of a standardized histopathologic protocol (Leeds Pathology Protocol, LEEPP).METHODS: One hundred and twenty-five patients underwent surgical resection because of PDAC of the pancreatic head. Patients were histopathologically examined according to a standardized protocol. Their oncologic outcome and clinicopathologic data were compared with those of a patient group before implementation of the LEEPP (n = 116).RESULTS: The R1 rate increased significantly from 13 to 52 %. There was no significant difference in OS between R0 and R1 resections. The median OS in patients with a tumor clearance of less than 2 mm from the resection margin was 15.1 months (12.1-18.1 months) versus 22.2 months (7.8-36.7 months) (P = 0.046). Multivariate analysis revealed a margin clearance or 2 mm and more as an independent prognosticator for OS.CONCLUSIONS: With applying the LEEPP, there was still no significant correlation between the R-status and OS in patients with PDAC. However, since a margin clearance of 2 mm or more is a predictive factor for OS, the R1 definition might have to be adapted in PDAC.

AB - BACKGROUND AND OBJECTIVES: The aim of this study was to assess the overall survival (OS) after R0/R1 resections in patients with pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head after implementation of a standardized histopathologic protocol (Leeds Pathology Protocol, LEEPP).METHODS: One hundred and twenty-five patients underwent surgical resection because of PDAC of the pancreatic head. Patients were histopathologically examined according to a standardized protocol. Their oncologic outcome and clinicopathologic data were compared with those of a patient group before implementation of the LEEPP (n = 116).RESULTS: The R1 rate increased significantly from 13 to 52 %. There was no significant difference in OS between R0 and R1 resections. The median OS in patients with a tumor clearance of less than 2 mm from the resection margin was 15.1 months (12.1-18.1 months) versus 22.2 months (7.8-36.7 months) (P = 0.046). Multivariate analysis revealed a margin clearance or 2 mm and more as an independent prognosticator for OS.CONCLUSIONS: With applying the LEEPP, there was still no significant correlation between the R-status and OS in patients with PDAC. However, since a margin clearance of 2 mm or more is a predictive factor for OS, the R1 definition might have to be adapted in PDAC.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Pancreatic Ductal

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasm, Residual

KW - Pancreatic Neoplasms

KW - Pancreaticoduodenectomy

KW - Prospective Studies

KW - Survival Rate

U2 - 10.1007/s00268-014-2808-4

DO - 10.1007/s00268-014-2808-4

M3 - SCORING: Journal article

C2 - 25270344

VL - 39

SP - 493

EP - 499

JO - WORLD J SURG

JF - WORLD J SURG

SN - 0364-2313

IS - 2

ER -