Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report
Standard
Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report. / Benjamin, Emelia J; Al-Khatib, Sana M; Desvigne-Nickens, Patrice; Alonso, Alvaro; Djoussé, Luc; Forman, Daniel E; Gillis, Anne M; Hendriks, Jeroen M L; Hills, Mellanie True; Kirchhof, Paulus; Link, Mark S; Marcus, Gregory M; Mehra, Reena; Murray, Katherine T; Parkash, Ratika; Piña, Ileana L; Redline, Susan; Rienstra, Michiel; Sanders, Prashanthan; Somers, Virend K; Van Wagoner, David R; Wang, Paul J; Cooper, Lawton S; Go, Alan S.
In: J AM HEART ASSOC, Vol. 10, No. 16, e021566, 17.08.2021.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report
AU - Benjamin, Emelia J
AU - Al-Khatib, Sana M
AU - Desvigne-Nickens, Patrice
AU - Alonso, Alvaro
AU - Djoussé, Luc
AU - Forman, Daniel E
AU - Gillis, Anne M
AU - Hendriks, Jeroen M L
AU - Hills, Mellanie True
AU - Kirchhof, Paulus
AU - Link, Mark S
AU - Marcus, Gregory M
AU - Mehra, Reena
AU - Murray, Katherine T
AU - Parkash, Ratika
AU - Piña, Ileana L
AU - Redline, Susan
AU - Rienstra, Michiel
AU - Sanders, Prashanthan
AU - Somers, Virend K
AU - Van Wagoner, David R
AU - Wang, Paul J
AU - Cooper, Lawton S
AU - Go, Alan S
PY - 2021/8/17
Y1 - 2021/8/17
N2 - There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF-related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevalence of AF nationally and internationally, the AF field needs transformative research and a commitment to evidenced-based secondary prevention strategies. We report on a National Heart, Lung, and Blood Institute virtual workshop directed at identifying knowledge gaps and research opportunities in the secondary prevention of AF. Once AF has been detected, lifestyle changes and novel models of care delivery may contribute to the prevention of AF recurrence, AF progression, and AF-related complications. Although benefits seen in small subgroups, cohort studies, and selected randomized trials are impressive, the widespread effectiveness of AF secondary prevention strategies remains unknown, calling for development of scalable interventions suitable for diverse populations and for identification of subpopulations who may particularly benefit from intensive management. We identified critical research questions for 6 topics relevant to the secondary prevention of AF: (1) weight loss; (2) alcohol intake, smoking cessation, and diet; (3) cardiac rehabilitation; (4) approaches to sleep disorders; (5) integrated, team-based care; and (6) nonanticoagulant pharmacotherapy. Our goal is to stimulate innovative research that will accelerate the generation of the evidence to effectively pursue the secondary prevention of AF.
AB - There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF-related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevalence of AF nationally and internationally, the AF field needs transformative research and a commitment to evidenced-based secondary prevention strategies. We report on a National Heart, Lung, and Blood Institute virtual workshop directed at identifying knowledge gaps and research opportunities in the secondary prevention of AF. Once AF has been detected, lifestyle changes and novel models of care delivery may contribute to the prevention of AF recurrence, AF progression, and AF-related complications. Although benefits seen in small subgroups, cohort studies, and selected randomized trials are impressive, the widespread effectiveness of AF secondary prevention strategies remains unknown, calling for development of scalable interventions suitable for diverse populations and for identification of subpopulations who may particularly benefit from intensive management. We identified critical research questions for 6 topics relevant to the secondary prevention of AF: (1) weight loss; (2) alcohol intake, smoking cessation, and diet; (3) cardiac rehabilitation; (4) approaches to sleep disorders; (5) integrated, team-based care; and (6) nonanticoagulant pharmacotherapy. Our goal is to stimulate innovative research that will accelerate the generation of the evidence to effectively pursue the secondary prevention of AF.
KW - Animals
KW - Anti-Arrhythmia Agents/therapeutic use
KW - Atrial Fibrillation/diagnosis
KW - Biomedical Research
KW - Body Composition
KW - Cardiac Rehabilitation
KW - Comorbidity
KW - Disease Progression
KW - Health Priorities
KW - Health Services Needs and Demand
KW - Healthy Lifestyle
KW - Humans
KW - National Heart, Lung, and Blood Institute (U.S.)
KW - Needs Assessment
KW - Recurrence
KW - Research Design
KW - Risk Assessment
KW - Risk Factors
KW - Secondary Prevention
KW - Treatment Outcome
KW - United States
KW - Weight Loss
U2 - 10.1161/JAHA.121.021566
DO - 10.1161/JAHA.121.021566
M3 - Other (editorial matter etc.)
C2 - 34351783
VL - 10
JO - J AM HEART ASSOC
JF - J AM HEART ASSOC
SN - 2047-9980
IS - 16
M1 - e021566
ER -
