Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia.

Martin Petzoldt; Stephan Braune; Iris Bittmann; Stefan Kluge

Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia.

Standard

Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia. / Petzoldt, Martin ; Braune, Stephan; Bittmann, Iris; Kluge, Stefan.

In: RESP CARE, Vol. 57, No. 2, 2, 2012, p. 293-297.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Petzoldt, M , Braune, S, Bittmann, I & Kluge, S 2012, 'Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia.', RESP CARE, vol. 57, no. 2, 2, pp. 293-297. <http://www.ncbi.nlm.nih.gov/pubmed/21762563?dopt=Citation>

APA

Petzoldt, M., Braune, S., Bittmann, I., & Kluge, S. (2012). Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia. RESP CARE, 57(2), 293-297. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21762563?dopt=Citation

Vancouver

Petzoldt M , Braune S, Bittmann I, Kluge S. Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia. RESP CARE. 2012;57(2):293-297. 2.

Bibtex

@article{ee85434912ff41cbb1cea8b4ac82296e,

title = "Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia.",

abstract = "Idiopathic interstitial pneumonia frequently causes severe pulmonary restriction that in turn makes mechanical ventilation difficult. We report the case of a 44-year-old woman who developed a refractory severe hypercapnic respiratory failure (P(aCO(2)) 281 mm Hg, pH 6.77) despite mechanical ventilation with high inspiratory pressure and PEEP. A pumpless extracorporeal lung assist device, Novalung, was used as rescue therapy for carbon dioxide removal, enabling lung-protective ventilation and normalization of life-threatening acidosis. Open lung biopsy revealed an idiopathic interstitial pneumonia with histological features of a nonspecific interstitial pneumonia. Corticosteroid therapy led to progressive improvement of pulmonary function, soon permitting cessation of mechanical ventilation and extracorporeal therapy. The patient was discharged from the intensive care unit after 20 days. This case demonstrates the successful use of pumpless extracorporeal lung assist as an alternative device to pump-driven extracorporeal membrane oxygenation in severe hypercapnic respiratory failure secondary to nonspecific interstitial pneumonia.",

keywords = "Adult, Biopsy, Humans, Female, Severity of Illness Index, Treatment Outcome, Acidosis/etiology/metabolism/*therapy, Carbon Dioxide/blood, *Extracorporeal Membrane Oxygenation/instrumentation/methods, Hypercapnia/etiology/metabolism/*therapy, *Idiopathic Interstitial Pneumonias/complications/metabolism/physiopathology/therapy, Lung/metabolism/pathology, Oxygenators, Membrane, Positive-Pressure Respiration/methods, Respiratory Insufficiency/etiology/metabolism/physiopathology/*therapy, Adult, Biopsy, Humans, Female, Severity of Illness Index, Treatment Outcome, Acidosis/etiology/metabolism/*therapy, Carbon Dioxide/blood, *Extracorporeal Membrane Oxygenation/instrumentation/methods, Hypercapnia/etiology/metabolism/*therapy, *Idiopathic Interstitial Pneumonias/complications/metabolism/physiopathology/therapy, Lung/metabolism/pathology, Oxygenators, Membrane, Positive-Pressure Respiration/methods, Respiratory Insufficiency/etiology/metabolism/physiopathology/*therapy",

author = "Martin Petzoldt and Stephan Braune and Iris Bittmann and Stefan Kluge",

year = "2012",

language = "English",

volume = "57",

pages = "293--297",

journal = "RESP CARE",

issn = "0020-1324",

publisher = "Daedalus Enterprises Inc.",

number = "2",

}

RIS

TY - JOUR

T1 - Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia.

AU - Petzoldt, Martin

AU - Braune, Stephan

AU - Bittmann, Iris

AU - Kluge, Stefan

PY - 2012

Y1 - 2012

N2 - Idiopathic interstitial pneumonia frequently causes severe pulmonary restriction that in turn makes mechanical ventilation difficult. We report the case of a 44-year-old woman who developed a refractory severe hypercapnic respiratory failure (P(aCO(2)) 281 mm Hg, pH 6.77) despite mechanical ventilation with high inspiratory pressure and PEEP. A pumpless extracorporeal lung assist device, Novalung, was used as rescue therapy for carbon dioxide removal, enabling lung-protective ventilation and normalization of life-threatening acidosis. Open lung biopsy revealed an idiopathic interstitial pneumonia with histological features of a nonspecific interstitial pneumonia. Corticosteroid therapy led to progressive improvement of pulmonary function, soon permitting cessation of mechanical ventilation and extracorporeal therapy. The patient was discharged from the intensive care unit after 20 days. This case demonstrates the successful use of pumpless extracorporeal lung assist as an alternative device to pump-driven extracorporeal membrane oxygenation in severe hypercapnic respiratory failure secondary to nonspecific interstitial pneumonia.

AB - Idiopathic interstitial pneumonia frequently causes severe pulmonary restriction that in turn makes mechanical ventilation difficult. We report the case of a 44-year-old woman who developed a refractory severe hypercapnic respiratory failure (P(aCO(2)) 281 mm Hg, pH 6.77) despite mechanical ventilation with high inspiratory pressure and PEEP. A pumpless extracorporeal lung assist device, Novalung, was used as rescue therapy for carbon dioxide removal, enabling lung-protective ventilation and normalization of life-threatening acidosis. Open lung biopsy revealed an idiopathic interstitial pneumonia with histological features of a nonspecific interstitial pneumonia. Corticosteroid therapy led to progressive improvement of pulmonary function, soon permitting cessation of mechanical ventilation and extracorporeal therapy. The patient was discharged from the intensive care unit after 20 days. This case demonstrates the successful use of pumpless extracorporeal lung assist as an alternative device to pump-driven extracorporeal membrane oxygenation in severe hypercapnic respiratory failure secondary to nonspecific interstitial pneumonia.

KW - Adult

KW - Biopsy

KW - Humans

KW - Female

KW - Severity of Illness Index

KW - Treatment Outcome

KW - Acidosis/etiology/metabolism/therapy

KW - Carbon Dioxide/blood

KW - Extracorporeal Membrane Oxygenation/instrumentation/methods

KW - Hypercapnia/etiology/metabolism/therapy

KW - Idiopathic Interstitial Pneumonias/complications/metabolism/physiopathology/therapy

KW - Lung/metabolism/pathology

KW - Oxygenators, Membrane

KW - Positive-Pressure Respiration/methods

KW - Respiratory Insufficiency/etiology/metabolism/physiopathology/therapy

KW - Adult

KW - Biopsy

KW - Humans

KW - Female

KW - Severity of Illness Index

KW - Treatment Outcome

KW - Acidosis/etiology/metabolism/therapy

KW - Carbon Dioxide/blood

KW - Extracorporeal Membrane Oxygenation/instrumentation/methods

KW - Hypercapnia/etiology/metabolism/therapy

KW - Idiopathic Interstitial Pneumonias/complications/metabolism/physiopathology/therapy

KW - Lung/metabolism/pathology

KW - Oxygenators, Membrane

KW - Positive-Pressure Respiration/methods

KW - Respiratory Insufficiency/etiology/metabolism/physiopathology/therapy

M3 - SCORING: Journal article

VL - 57

SP - 293

EP - 297

JO - RESP CARE

JF - RESP CARE

SN - 0020-1324

IS - 2

M1 - 2

ER -