Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

H W Mittrücker; T Matsuyama; A Grossman; T M Kündig; J Potter; A Shahinian; A Wakeham; B Patterson; P S Ohashi; T W Mak

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

Standard

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. / Mittrücker, H W; Matsuyama, T; Grossman, A; Kündig, T M; Potter, J; Shahinian, A; Wakeham, A; Patterson, B; Ohashi, P S; Mak, T W.

In: SCIENCE, Vol. 275, No. 5299, 24.01.1997, p. 540-3.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mittrücker, HW, Matsuyama, T, Grossman, A, Kündig, TM, Potter, J, Shahinian, A, Wakeham, A, Patterson, B, Ohashi, PS & Mak, TW 1997, 'Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function', SCIENCE, vol. 275, no. 5299, pp. 540-3.

APA

Mittrücker, H. W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W. (1997). Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. SCIENCE, 275(5299), 540-3.

Vancouver

Mittrücker HW, Matsuyama T, Grossman A, Kündig TM, Potter J, Shahinian A et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. SCIENCE. 1997 Jan 24;275(5299):540-3.

Bibtex

@article{a3277ed9cb1245fc85d20b74a4c767d7,

title = "Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function",

abstract = "Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.",

keywords = "Animals, Antigen Presentation, B-Lymphocytes, Bone Marrow Cells, Cytotoxicity, Immunologic, DNA-Binding Proteins, Female, Gene Targeting, Graft vs Host Reaction, Immunization, Immunoglobulins, Interferon Regulatory Factors, Lymphatic Diseases, Lymphocyte Activation, Lymphocyte Subsets, Lymphoid Tissue, Male, Mast-Cell Sarcoma, Mice, Mice, Inbred C57BL, Mice, SCID, Neoplasm Transplantation, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Transcription Factors",

author = "Mittr{\"u}cker, {H W} and T Matsuyama and A Grossman and K{\"u}ndig, {T M} and J Potter and A Shahinian and A Wakeham and B Patterson and Ohashi, {P S} and Mak, {T W}",

year = "1997",

month = jan,

day = "24",

language = "English",

volume = "275",

pages = "540--3",

journal = "SCIENCE",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5299",

}

RIS

TY - JOUR

T1 - Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

AU - Mittrücker, H W

AU - Matsuyama, T

AU - Grossman, A

AU - Kündig, T M

AU - Potter, J

AU - Shahinian, A

AU - Wakeham, A

AU - Patterson, B

AU - Ohashi, P S

AU - Mak, T W

PY - 1997/1/24

Y1 - 1997/1/24

N2 - Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

AB - Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

KW - Animals

KW - Antigen Presentation

KW - B-Lymphocytes

KW - Bone Marrow Cells

KW - Cytotoxicity, Immunologic

KW - DNA-Binding Proteins

KW - Female

KW - Gene Targeting

KW - Graft vs Host Reaction

KW - Immunization

KW - Immunoglobulins

KW - Interferon Regulatory Factors

KW - Lymphatic Diseases

KW - Lymphocyte Activation

KW - Lymphocyte Subsets

KW - Lymphoid Tissue

KW - Male

KW - Mast-Cell Sarcoma

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, SCID

KW - Neoplasm Transplantation

KW - T-Lymphocytes

KW - T-Lymphocytes, Cytotoxic

KW - Transcription Factors

M3 - SCORING: Journal article

C2 - 8999800

VL - 275

SP - 540

EP - 543

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 5299

ER -