Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Martin Zickler; Stephanie Stanelle-Bertram; Sandra Ehret; Fabian Heinrich; Philine Lange; Berfin Schaumburg; Nancy Mounogou Kouassi; Sebastian Beck; Michelle Y Jaeckstein; Oliver Mann; Susanne Krasemann; Maria Schroeder; Dominik Jarczak; Axel Nierhaus; Stefan Kluge; Manuela Peschka; Hartmut Schlüter; Thomas Renné; Klaus Pueschel; Andreas Kloetgen; Ludger Scheja; Benjamin Ondruschka; Joerg Heeren; Guelsah Gabriel

doi:10.1016/j.cmet.2021.12.002

Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Martin Zickler (Shared first author)
Stephanie Stanelle-Bertram (Shared first author)
Sandra Ehret (Shared first author)
Fabian Heinrich
Philine Lange
Berfin Schaumburg
Nancy Mounogou Kouassi
Sebastian Beck
Michelle Y Jaeckstein
Oliver Mann
Susanne Krasemann
Maria Schroeder
Dominik Jarczak
Axel Nierhaus
Stefan Kluge
Manuela Peschka
Hartmut Schlüter
Thomas Renné
Klaus Pueschel
Andreas Kloetgen
Ludger Scheja
Benjamin Ondruschka
Joerg Heeren (Shared last author)
Guelsah Gabriel (Shared last author)

Related Research units

Abstract

Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.

Bibliographical data

Original language	English
ISSN	1550-4131
DOIs	https://doi.org/10.1016/j.cmet.2021.12.002
Publication status	Published - 04.01.2022

Comment Deanary

PubMed	34895500