Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation
Related Research units
Abstract
Most cognitive functions involving the prefrontal cortex emerge during late development. Increasing evidence links this delayed maturation to the protracted timeline of prefrontal development, which likely does not reach full maturity before the end of adolescence. However, the underlying mechanisms that drive the emergence and fine-tuning of cognitive abilities during adolescence, caused by circuit wiring, are still unknown. Here, we continuously monitored prefrontal activity throughout the postnatal development of mice and showed that an initial activity increase was interrupted by an extensive microglia-mediated breakdown of activity, followed by the rewiring of circuit elements to achieve adult-like patterns and synchrony. Interfering with these processes during adolescence, but not adulthood, led to a long-lasting microglia-induced disruption of prefrontal activity and neuronal morphology and decreased cognitive abilities. These results identified a nonlinear reorganization of prefrontal circuits during adolescence and revealed its importance for adult network function and cognitive processing.
Bibliographical data
Original language | English |
---|---|
ISSN | 0896-6273 |
DOIs | |
Publication status | Published - 07.02.2024 |
Comment Deanary
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
PubMed | 37979584 |
---|