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Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor

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Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor. / Despotović, Sanja Z; Milićević, Novica M; Milošević, Dragoslav P; Despotović, Nebojša; Erceg, Predrag; Svorcan, Petar; Schumacher, Udo; Ullrich, Sebastian; Mihajlović, Gordana; Kalem, Dragan; Marković, Srđan; Lalić, Ivana M; Krmpot, Aleksandar J; Rabasović, Mihailo D; Pantelić, Dejan V; Jovanić, Svetlana Z; Rösch, Thomas; Milićević, Živana.

In: TUMOR BIOL, Vol. 39, No. 7, 07.2017, p. 1-10.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Despotović, SZ, Milićević, NM, Milošević, DP, Despotović, N, Erceg, P, Svorcan, P, Schumacher, U, Ullrich, S, Mihajlović, G, Kalem, D, Marković, S, Lalić, IM, Krmpot, AJ, Rabasović, MD, Pantelić, DV, Jovanić, SZ, Rösch, T & Milićević, Ž 2017, 'Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor', TUMOR BIOL, vol. 39, no. 7, pp. 1-10. https://doi.org/10.1177/1010428317711654

APA

Despotović, S. Z., Milićević, N. M., Milošević, D. P., Despotović, N., Erceg, P., Svorcan, P., Schumacher, U., Ullrich, S., Mihajlović, G., Kalem, D., Marković, S., Lalić, I. M., Krmpot, A. J., Rabasović, M. D., Pantelić, D. V., Jovanić, S. Z., Rösch, T., & Milićević, Ž. (2017). Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor. TUMOR BIOL, 39(7), 1-10. https://doi.org/10.1177/1010428317711654

Vancouver

Despotović SZ, Milićević NM, Milošević DP, Despotović N, Erceg P, Svorcan P et al. Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor. TUMOR BIOL. 2017 Jul;39(7):1-10. https://doi.org/10.1177/1010428317711654

Bibtex

@article{fe6ef260089d4ce59f389151d46d3f51,
title = "Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor",
abstract = "In recent years, it has been demonstrated that malignancy arises and advances through the molecular interplay between tumor cells and non-malignant elements of the tumor stroma, that is, fibroblasts and extracellular matrix. However, in contrast to the mounting evidence about the role of tumor stroma in the genesis and progression of the malignant disease, there are very few data regarding the uninvolved stromal tissue in the remote surrounding of the tumor. Using the objective morphometric approach in patients with adenocarcinoma, we demonstrate the remodeling of extracellular matrix of the lamina propria in the uninvolved rectal mucosa 10 and 20 cm away from the neoplasm. We show that the representation of basic extracellular matrix constituents (reticular and collagen fibers and ground substance) is decreased. Also, the diameter of empty spaces that appear within the extracellular matrix of the lamina propria is increased. These spaces do not represent the blood or lymphatic vessel elements. Very likely, they reflect the development of tissue edema in the remote, uninvolved lamina propria of the mucosa in patients with the malignant tumor of the rectum. We hypothesize that the remodeling of extracellular matrix in lamina propria of the rectal mucosa may increase its stiffness, modulating the mechano-signal transduction, and thus promote the progression of the malignant disease.",
keywords = "Adenocarcinoma, Aged, Blood Vessels, Carcinogenesis, Disease Progression, Extracellular Matrix, Female, Humans, Intestinal Mucosa, Male, Mucous Membrane, Rectal Neoplasms, Journal Article",
author = "Despotovi{\'c}, {Sanja Z} and Mili{\'c}evi{\'c}, {Novica M} and Milo{\v s}evi{\'c}, {Dragoslav P} and Neboj{\v s}a Despotovi{\'c} and Predrag Erceg and Petar Svorcan and Udo Schumacher and Sebastian Ullrich and Gordana Mihajlovi{\'c} and Dragan Kalem and Sr{\d}an Markovi{\'c} and Lali{\'c}, {Ivana M} and Krmpot, {Aleksandar J} and Rabasovi{\'c}, {Mihailo D} and Panteli{\'c}, {Dejan V} and Jovani{\'c}, {Svetlana Z} and Thomas R{\"o}sch and {\v Z}ivana Mili{\'c}evi{\'c}",
year = "2017",
month = jul,
doi = "10.1177/1010428317711654",
language = "English",
volume = "39",
pages = "1--10",
journal = "TUMOR BIOL",
issn = "1010-4283",
publisher = "Springer Netherlands",
number = "7",

}

RIS

TY - JOUR

T1 - Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor

AU - Despotović, Sanja Z

AU - Milićević, Novica M

AU - Milošević, Dragoslav P

AU - Despotović, Nebojša

AU - Erceg, Predrag

AU - Svorcan, Petar

AU - Schumacher, Udo

AU - Ullrich, Sebastian

AU - Mihajlović, Gordana

AU - Kalem, Dragan

AU - Marković, Srđan

AU - Lalić, Ivana M

AU - Krmpot, Aleksandar J

AU - Rabasović, Mihailo D

AU - Pantelić, Dejan V

AU - Jovanić, Svetlana Z

AU - Rösch, Thomas

AU - Milićević, Živana

PY - 2017/7

Y1 - 2017/7

N2 - In recent years, it has been demonstrated that malignancy arises and advances through the molecular interplay between tumor cells and non-malignant elements of the tumor stroma, that is, fibroblasts and extracellular matrix. However, in contrast to the mounting evidence about the role of tumor stroma in the genesis and progression of the malignant disease, there are very few data regarding the uninvolved stromal tissue in the remote surrounding of the tumor. Using the objective morphometric approach in patients with adenocarcinoma, we demonstrate the remodeling of extracellular matrix of the lamina propria in the uninvolved rectal mucosa 10 and 20 cm away from the neoplasm. We show that the representation of basic extracellular matrix constituents (reticular and collagen fibers and ground substance) is decreased. Also, the diameter of empty spaces that appear within the extracellular matrix of the lamina propria is increased. These spaces do not represent the blood or lymphatic vessel elements. Very likely, they reflect the development of tissue edema in the remote, uninvolved lamina propria of the mucosa in patients with the malignant tumor of the rectum. We hypothesize that the remodeling of extracellular matrix in lamina propria of the rectal mucosa may increase its stiffness, modulating the mechano-signal transduction, and thus promote the progression of the malignant disease.

AB - In recent years, it has been demonstrated that malignancy arises and advances through the molecular interplay between tumor cells and non-malignant elements of the tumor stroma, that is, fibroblasts and extracellular matrix. However, in contrast to the mounting evidence about the role of tumor stroma in the genesis and progression of the malignant disease, there are very few data regarding the uninvolved stromal tissue in the remote surrounding of the tumor. Using the objective morphometric approach in patients with adenocarcinoma, we demonstrate the remodeling of extracellular matrix of the lamina propria in the uninvolved rectal mucosa 10 and 20 cm away from the neoplasm. We show that the representation of basic extracellular matrix constituents (reticular and collagen fibers and ground substance) is decreased. Also, the diameter of empty spaces that appear within the extracellular matrix of the lamina propria is increased. These spaces do not represent the blood or lymphatic vessel elements. Very likely, they reflect the development of tissue edema in the remote, uninvolved lamina propria of the mucosa in patients with the malignant tumor of the rectum. We hypothesize that the remodeling of extracellular matrix in lamina propria of the rectal mucosa may increase its stiffness, modulating the mechano-signal transduction, and thus promote the progression of the malignant disease.

KW - Adenocarcinoma

KW - Aged

KW - Blood Vessels

KW - Carcinogenesis

KW - Disease Progression

KW - Extracellular Matrix

KW - Female

KW - Humans

KW - Intestinal Mucosa

KW - Male

KW - Mucous Membrane

KW - Rectal Neoplasms

KW - Journal Article

U2 - 10.1177/1010428317711654

DO - 10.1177/1010428317711654

M3 - SCORING: Journal article

C2 - 28718368

VL - 39

SP - 1

EP - 10

JO - TUMOR BIOL

JF - TUMOR BIOL

SN - 1010-4283

IS - 7

ER -