Relevance of Notch Signaling for Bone Metabolism and Regeneration
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Relevance of Notch Signaling for Bone Metabolism and Regeneration. / Ballhause, Tobias M; Jiang, Shan; Baranowsky, Anke; Brandt, Sabine; Mertens, Peter R; Frosch, Karl-Heinz; Yorgan, Timur; Keller, Johannes.
In: INT J MOL SCI, Vol. 22, No. 3, 29.01.2021.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Relevance of Notch Signaling for Bone Metabolism and Regeneration
AU - Ballhause, Tobias M
AU - Jiang, Shan
AU - Baranowsky, Anke
AU - Brandt, Sabine
AU - Mertens, Peter R
AU - Frosch, Karl-Heinz
AU - Yorgan, Timur
AU - Keller, Johannes
PY - 2021/1/29
Y1 - 2021/1/29
N2 - Notch1-4 receptors and their signaling pathways are expressed in almost all organ systems and play a pivotal role in cell fate decision by coordinating cell proliferation, differentiation and apoptosis. Differential expression and activation of Notch signaling pathways has been observed in a variety of organs and tissues under physiological and pathological conditions. Bone tissue represents a dynamic system, which is constantly remodeled throughout life. In bone, Notch receptors have been shown to control remodeling and regeneration. Numerous functions have been assigned to Notch receptors and ligands, including osteoblast differentiation and matrix mineralization, osteoclast recruitment and cell fusion and osteoblast/osteoclast progenitor cell proliferation. The expression and function of Notch1-4 in the skeleton are distinct and closely depend on the temporal expression at different differentiation stages. This review addresses the current knowledge on Notch signaling in adult bone with emphasis on metabolism, bone regeneration and degenerative skeletal disorders, as well as congenital disorders associated with mutant Notch genes. Moreover, the crosstalk between Notch signaling and other important pathways involved in bone turnover, including Wnt/β-catenin, BMP and RANKL/OPG, are outlined.
AB - Notch1-4 receptors and their signaling pathways are expressed in almost all organ systems and play a pivotal role in cell fate decision by coordinating cell proliferation, differentiation and apoptosis. Differential expression and activation of Notch signaling pathways has been observed in a variety of organs and tissues under physiological and pathological conditions. Bone tissue represents a dynamic system, which is constantly remodeled throughout life. In bone, Notch receptors have been shown to control remodeling and regeneration. Numerous functions have been assigned to Notch receptors and ligands, including osteoblast differentiation and matrix mineralization, osteoclast recruitment and cell fusion and osteoblast/osteoclast progenitor cell proliferation. The expression and function of Notch1-4 in the skeleton are distinct and closely depend on the temporal expression at different differentiation stages. This review addresses the current knowledge on Notch signaling in adult bone with emphasis on metabolism, bone regeneration and degenerative skeletal disorders, as well as congenital disorders associated with mutant Notch genes. Moreover, the crosstalk between Notch signaling and other important pathways involved in bone turnover, including Wnt/β-catenin, BMP and RANKL/OPG, are outlined.
U2 - 10.3390/ijms22031325
DO - 10.3390/ijms22031325
M3 - SCORING: Review article
C2 - 33572704
VL - 22
JO - INT J MOL SCI
JF - INT J MOL SCI
SN - 1661-6596
IS - 3
ER -