Research ExplorerPublicationsRelaxin Treatment in an Ang-II-Based Transgenic Preeclamptic...

Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model

Standard

Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model. / Haase, Nadine; Golic, Michaela; Herse, Florian; Rugor, Julianna; Linz, Dominik; Solano, Maria Emilia; Müller, Dominik N; Dechend, Ralf.

In: PLOS ONE, Vol. 11, No. 3, 2016, p. e0150743.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Haase, N, Golic, M, Herse, F, Rugor, J, Linz, D, Solano, ME, Müller, DN & Dechend, R 2016, 'Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model', PLOS ONE, vol. 11, no. 3, pp. e0150743. https://doi.org/10.1371/journal.pone.0150743

APA

Haase, N., Golic, M., Herse, F., Rugor, J., Linz, D., Solano, M. E., Müller, D. N., & Dechend, R. (2016). Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model. PLOS ONE, 11(3), e0150743. https://doi.org/10.1371/journal.pone.0150743

Vancouver

Haase N, Golic M, Herse F, Rugor J, Linz D, Solano ME et al. Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model. PLOS ONE. 2016;11(3):e0150743. https://doi.org/10.1371/journal.pone.0150743

Bibtex

@article{91259c1be4b34df09162d61605734f69,
title = "Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model",
abstract = "Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur. Relaxin controls the hemodynamic and renovascular adaptive changes that occur during pregnancy. Interest has evolved regarding relaxin and a therapeutic principle in preeclampsia and heart failure. Preeclampsia is a pregnancy disorder, featuring hypertension, proteinuria and placental anomalies. We investigated relaxin in an established transgenic rat model of preeclampsia, where the phenotype is induced by angiotensin (Ang)-II production in mid pregnancy. We gave recombinant relaxin to preeclamtic rats at day 9 of gestation. Hypertension and proteinuria was not ameliorated after relaxin administration. Intrauterine growth retardation of the fetus was unaltered by relaxin. Heart-rate responses and relaxin levels documented drug effects. In this Ang-II-based model of preeclampsia, we could not show a salubrious effect on preeclampsia.",
keywords = "Angiotensins, Animals, Disease Models, Animal, Female, Fetal Growth Retardation, Pre-Eclampsia, Pregnancy, Rats, Rats, Transgenic, Relaxin, Journal Article, Research Support, Non-U.S. Gov't",
author = "Nadine Haase and Michaela Golic and Florian Herse and Julianna Rugor and Dominik Linz and Solano, {Maria Emilia} and M{\"u}ller, {Dominik N} and Ralf Dechend",
year = "2016",
doi = "10.1371/journal.pone.0150743",
language = "English",
volume = "11",
pages = "e0150743",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model

AU - Haase, Nadine

AU - Golic, Michaela

AU - Herse, Florian

AU - Rugor, Julianna

AU - Linz, Dominik

AU - Solano, Maria Emilia

AU - Müller, Dominik N

AU - Dechend, Ralf

PY - 2016

Y1 - 2016

N2 - Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur. Relaxin controls the hemodynamic and renovascular adaptive changes that occur during pregnancy. Interest has evolved regarding relaxin and a therapeutic principle in preeclampsia and heart failure. Preeclampsia is a pregnancy disorder, featuring hypertension, proteinuria and placental anomalies. We investigated relaxin in an established transgenic rat model of preeclampsia, where the phenotype is induced by angiotensin (Ang)-II production in mid pregnancy. We gave recombinant relaxin to preeclamtic rats at day 9 of gestation. Hypertension and proteinuria was not ameliorated after relaxin administration. Intrauterine growth retardation of the fetus was unaltered by relaxin. Heart-rate responses and relaxin levels documented drug effects. In this Ang-II-based model of preeclampsia, we could not show a salubrious effect on preeclampsia.

AB - Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur. Relaxin controls the hemodynamic and renovascular adaptive changes that occur during pregnancy. Interest has evolved regarding relaxin and a therapeutic principle in preeclampsia and heart failure. Preeclampsia is a pregnancy disorder, featuring hypertension, proteinuria and placental anomalies. We investigated relaxin in an established transgenic rat model of preeclampsia, where the phenotype is induced by angiotensin (Ang)-II production in mid pregnancy. We gave recombinant relaxin to preeclamtic rats at day 9 of gestation. Hypertension and proteinuria was not ameliorated after relaxin administration. Intrauterine growth retardation of the fetus was unaltered by relaxin. Heart-rate responses and relaxin levels documented drug effects. In this Ang-II-based model of preeclampsia, we could not show a salubrious effect on preeclampsia.

KW - Angiotensins

KW - Animals

KW - Disease Models, Animal

KW - Female

KW - Fetal Growth Retardation

KW - Pre-Eclampsia

KW - Pregnancy

KW - Rats

KW - Rats, Transgenic

KW - Relaxin

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1371/journal.pone.0150743

DO - 10.1371/journal.pone.0150743

M3 - SCORING: Journal article

C2 - 26963382

VL - 11

SP - e0150743

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 3

ER -