Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background
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Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background. / van Paridon, Pauline C S; Panova-Noeva, Marina; van Oerle, Rene; Schulz, Andreas; Prochaska, Jürgen H; Arnold, Natalie; Schmidtmann, Irene; Beutel, Manfred; Pfeiffer, Norbert; Münzel, Thomas; Lackner, Karl J; Ten Cate, Hugo; Wild, Philipp S; Spronk, Henri M H.
In: THROMB J, Vol. 20, No. 1, 32, 08.06.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background
AU - van Paridon, Pauline C S
AU - Panova-Noeva, Marina
AU - van Oerle, Rene
AU - Schulz, Andreas
AU - Prochaska, Jürgen H
AU - Arnold, Natalie
AU - Schmidtmann, Irene
AU - Beutel, Manfred
AU - Pfeiffer, Norbert
AU - Münzel, Thomas
AU - Lackner, Karl J
AU - Ten Cate, Hugo
AU - Wild, Philipp S
AU - Spronk, Henri M H
N1 - © 2022. The Author(s).
PY - 2022/6/8
Y1 - 2022/6/8
N2 - BACKGROUND: The current study aims to identify the relationships between coagulation factors and plasma thrombin generation in a large population-based study by comparing individuals with a history of arterial or venous thrombosis to cardiovascular healthy individuals.METHODS: This study comprised 502 individuals with a history of arterial disease, 195 with history of venous thrombosis and 1402 cardiovascular healthy individuals (reference group) from the population-based Gutenberg Health Study (GHS). Calibrated Automated Thrombography was assessed and coagulation factors were measured by means of BCS XP Systems. To assess the biochemical determinants of TG variables, a multiple linear regression analysis, adjusted for age, sex and antithrombotic therapy, was conducted.RESULTS: The lag time, the time to form the first thrombin, was mainly positively associated with the natural coagulant and anti-coagulant factors in the reference group, i.e. higher factors result in a longer lag time. The same determinants were negative for individuals with a history of arterial or venous thrombosis, with a 10 times higher effect size. Endogenous thrombin potential, or area under the curve, was predominantly positively determined by factor II, VIII, X and IX in all groups. However, the effect sizes of the reported associations were 4 times higher for the arterial and venous disease groups in comparison to the reference group.CONCLUSION: This large-scale analysis demonstrated a stronger effect of the coagulant and natural anti-coagulant factors on the thrombin potential in individuals with a history of arterial or venous thrombosis as compared to healthy individuals, which implicates sustained alterations in the plasma coagulome in subjects with a history of thrombotic vascular disease, despite intake of antithrombotic therapy.
AB - BACKGROUND: The current study aims to identify the relationships between coagulation factors and plasma thrombin generation in a large population-based study by comparing individuals with a history of arterial or venous thrombosis to cardiovascular healthy individuals.METHODS: This study comprised 502 individuals with a history of arterial disease, 195 with history of venous thrombosis and 1402 cardiovascular healthy individuals (reference group) from the population-based Gutenberg Health Study (GHS). Calibrated Automated Thrombography was assessed and coagulation factors were measured by means of BCS XP Systems. To assess the biochemical determinants of TG variables, a multiple linear regression analysis, adjusted for age, sex and antithrombotic therapy, was conducted.RESULTS: The lag time, the time to form the first thrombin, was mainly positively associated with the natural coagulant and anti-coagulant factors in the reference group, i.e. higher factors result in a longer lag time. The same determinants were negative for individuals with a history of arterial or venous thrombosis, with a 10 times higher effect size. Endogenous thrombin potential, or area under the curve, was predominantly positively determined by factor II, VIII, X and IX in all groups. However, the effect sizes of the reported associations were 4 times higher for the arterial and venous disease groups in comparison to the reference group.CONCLUSION: This large-scale analysis demonstrated a stronger effect of the coagulant and natural anti-coagulant factors on the thrombin potential in individuals with a history of arterial or venous thrombosis as compared to healthy individuals, which implicates sustained alterations in the plasma coagulome in subjects with a history of thrombotic vascular disease, despite intake of antithrombotic therapy.
U2 - 10.1186/s12959-022-00392-0
DO - 10.1186/s12959-022-00392-0
M3 - SCORING: Journal article
C2 - 35676710
VL - 20
JO - THROMB J
JF - THROMB J
SN - 1477-9560
IS - 1
M1 - 32
ER -