Relationship between plasma Neuregulin-1 and cardiac function in patients with ST-elevation myocardial infarction
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Relationship between plasma Neuregulin-1 and cardiac function in patients with ST-elevation myocardial infarction. / Haller, Paul M; Gonçalves, Inês F; Acar, Eylem; Jäger, Bernhard; Pilz, Patrick M; Wojta, Johann; Huber, Kurt; Kiss, Attila; Podesser, Bruno K.
In: REV CARDIOVASC MED, Vol. 23, No. 2, 14.02.2022, p. 63.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Relationship between plasma Neuregulin-1 and cardiac function in patients with ST-elevation myocardial infarction
AU - Haller, Paul M
AU - Gonçalves, Inês F
AU - Acar, Eylem
AU - Jäger, Bernhard
AU - Pilz, Patrick M
AU - Wojta, Johann
AU - Huber, Kurt
AU - Kiss, Attila
AU - Podesser, Bruno K
N1 - © 2022 The Author(s). Published by IMR Press.
PY - 2022/2/14
Y1 - 2022/2/14
N2 - BACKGROUND: Neuregulin-1 (NRG-1) is a stress-mediated transmembrane growth factor. Reduced myocardial damage and higher NRG-1 levels upon treatment with remote ischemic conditioning (RIC) has been described in rats. However, the role of NRG-1 in patients with acute myocardial infarction (MI) is unknown. Thus, we conducted a post hoc analysis of a randomized controlled trial that tested RIC in patients with MI scheduled for primary percutaneous coronary intervention (PCI).METHODS: Blood was drawn from 30 patients before RIC/PCI, within 1 hour, 4 days and 1 month later. Median left ventricular ejection fraction (LVEF) in the overall study population following MI was 48.5%.RESULTS: NRG-1 plasma levels decreased significantly following PCI/RIC and remained decreased up to 1 month following MI (p < 0.0001). We observed no association of NRG-1 with other variables, including total ischemic time, LVEF or RIC.CONCLUSIONS: Thus, we identified NRG-1 may be independently affected by MI. However, further large clinical trials are warranted to clarify this hypothesis.
AB - BACKGROUND: Neuregulin-1 (NRG-1) is a stress-mediated transmembrane growth factor. Reduced myocardial damage and higher NRG-1 levels upon treatment with remote ischemic conditioning (RIC) has been described in rats. However, the role of NRG-1 in patients with acute myocardial infarction (MI) is unknown. Thus, we conducted a post hoc analysis of a randomized controlled trial that tested RIC in patients with MI scheduled for primary percutaneous coronary intervention (PCI).METHODS: Blood was drawn from 30 patients before RIC/PCI, within 1 hour, 4 days and 1 month later. Median left ventricular ejection fraction (LVEF) in the overall study population following MI was 48.5%.RESULTS: NRG-1 plasma levels decreased significantly following PCI/RIC and remained decreased up to 1 month following MI (p < 0.0001). We observed no association of NRG-1 with other variables, including total ischemic time, LVEF or RIC.CONCLUSIONS: Thus, we identified NRG-1 may be independently affected by MI. However, further large clinical trials are warranted to clarify this hypothesis.
KW - Animals
KW - Humans
KW - Neuregulin-1
KW - Percutaneous Coronary Intervention/adverse effects
KW - Rats
KW - ST Elevation Myocardial Infarction/diagnosis
KW - Stroke Volume
KW - Treatment Outcome
KW - Ventricular Function, Left
U2 - 10.31083/j.rcm2302063
DO - 10.31083/j.rcm2302063
M3 - SCORING: Journal article
C2 - 35229554
VL - 23
SP - 63
JO - REV CARDIOVASC MED
JF - REV CARDIOVASC MED
SN - 1530-6550
IS - 2
ER -
