Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample

Pauline C S van Paridon; Marina Panova-Noeva; Rene van Oerle; Andreas Schulz; Jürgen H Prochaska; Natalie Arnold; Irene Schmidtmann; Manfred Beutel; Norbert Pfeiffer; Thomas Münzel; Karl J Lackner; Tilman M Hackeng; Hugo Ten Cate; Philipp S Wild; Henri M H Spronk

doi:10.1055/s-0040-1715897

Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample

Standard

Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample. / van Paridon, Pauline C S; Panova-Noeva, Marina; van Oerle, Rene; Schulz, Andreas; Prochaska, Jürgen H; Arnold, Natalie; Schmidtmann, Irene; Beutel, Manfred; Pfeiffer, Norbert; Münzel, Thomas; Lackner, Karl J; Hackeng, Tilman M; Ten Cate, Hugo; Wild, Philipp S; Spronk, Henri M H.

In: THROMB HAEMOSTASIS, Vol. 121, No. 2, 02.2021, p. 174-181.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

van Paridon, PCS, Panova-Noeva, M, van Oerle, R, Schulz, A, Prochaska, JH, Arnold, N, Schmidtmann, I, Beutel, M, Pfeiffer, N, Münzel, T, Lackner, KJ, Hackeng, TM, Ten Cate, H, Wild, PS & Spronk, HMH 2021, 'Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample', THROMB HAEMOSTASIS, vol. 121, no. 2, pp. 174-181. https://doi.org/10.1055/s-0040-1715897

APA

van Paridon, P. C. S., Panova-Noeva, M., van Oerle, R., Schulz, A., Prochaska, J. H., Arnold, N., Schmidtmann, I., Beutel, M., Pfeiffer, N., Münzel, T., Lackner, K. J., Hackeng, T. M., Ten Cate, H., Wild, P. S., & Spronk, H. M. H. (2021). Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample. THROMB HAEMOSTASIS, 121(2), 174-181. https://doi.org/10.1055/s-0040-1715897

Vancouver

van Paridon PCS, Panova-Noeva M, van Oerle R, Schulz A, Prochaska JH, Arnold N et al. Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample. THROMB HAEMOSTASIS. 2021 Feb;121(2):174-181. https://doi.org/10.1055/s-0040-1715897

Bibtex

@article{7833acc0f1c34bed918744f4b85218aa,

title = "Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample",

abstract = "OBJECTIVE: Tissue factor pathway inhibitor (TFPI) is a potent anticoagulant protein in the extrinsic coagulation pathway. In the present study, we aim to identify the cardiovascular determinants for total TFPI activity and its association with cardiovascular disease (CVD) and total mortality.METHODS: Total TFPI activity was assessed in a selection of the population-based Gutenberg Health Study (n = 5,000). Statistical analysis was performed to identify the determinants for total TFPI activity as well as the associations with CVD and mortality.RESULTS: Multivariable linear regression analysis identified smoking (β 0.095 [0.054-0.136]) as a positive determinant for total TFPI activity, while diabetes (β -0.072 [-0.134 to -0.009]), obesity (β -0.063 [-0.101 to -0.024]), and history of coronary artery disease (CAD) were negatively associated with total TFPI activity, independent of age, sex, and the remaining cardiovascular risk factors. After adjustment for lipoprotein levels, the association between total TFPI activity levels and obesity and CAD was lost. The analysis additionally revealed a strong positive association between total TFPI activity levels and low-density lipoprotein (β 0.221 [0.204-0.237]). The Cox regression models revealed that a higher total TFPI activity, above 97.5th percentile of the reference group, was associated with an increased mortality risk (hazard ratio = 2.58 [95% confidence interval: 1.49-4.47]), independent of age, sex, and cardiovascular risk profile.CONCLUSION: In the Gutenberg Health Study population-based cohort, the highest percentage of total TFPI correlated with an increased mortality risk. While elevated TFPI may reflect endothelial cell activation, the associations between total TFPI activity and obesity and CAD, points to additional mechanistic interactions.",

author = "{van Paridon}, {Pauline C S} and Marina Panova-Noeva and {van Oerle}, Rene and Andreas Schulz and Prochaska, {J{\"u}rgen H} and Natalie Arnold and Irene Schmidtmann and Manfred Beutel and Norbert Pfeiffer and Thomas M{\"u}nzel and Lackner, {Karl J} and Hackeng, {Tilman M} and {Ten Cate}, Hugo and Wild, {Philipp S} and Spronk, {Henri M H}",

year = "2021",

month = feb,

doi = "10.1055/s-0040-1715897",

language = "English",

volume = "121",

pages = "174--181",

journal = "THROMB HAEMOSTASIS",

issn = "0340-6245",

publisher = "Schattauer",

number = "2",

}

RIS

TY - JOUR

T1 - Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample

AU - van Paridon, Pauline C S

AU - Panova-Noeva, Marina

AU - van Oerle, Rene

AU - Schulz, Andreas

AU - Prochaska, Jürgen H

AU - Arnold, Natalie

AU - Schmidtmann, Irene

AU - Beutel, Manfred

AU - Pfeiffer, Norbert

AU - Münzel, Thomas

AU - Lackner, Karl J

AU - Hackeng, Tilman M

AU - Ten Cate, Hugo

AU - Wild, Philipp S

AU - Spronk, Henri M H

PY - 2021/2

Y1 - 2021/2

N2 - OBJECTIVE: Tissue factor pathway inhibitor (TFPI) is a potent anticoagulant protein in the extrinsic coagulation pathway. In the present study, we aim to identify the cardiovascular determinants for total TFPI activity and its association with cardiovascular disease (CVD) and total mortality.METHODS: Total TFPI activity was assessed in a selection of the population-based Gutenberg Health Study (n = 5,000). Statistical analysis was performed to identify the determinants for total TFPI activity as well as the associations with CVD and mortality.RESULTS: Multivariable linear regression analysis identified smoking (β 0.095 [0.054-0.136]) as a positive determinant for total TFPI activity, while diabetes (β -0.072 [-0.134 to -0.009]), obesity (β -0.063 [-0.101 to -0.024]), and history of coronary artery disease (CAD) were negatively associated with total TFPI activity, independent of age, sex, and the remaining cardiovascular risk factors. After adjustment for lipoprotein levels, the association between total TFPI activity levels and obesity and CAD was lost. The analysis additionally revealed a strong positive association between total TFPI activity levels and low-density lipoprotein (β 0.221 [0.204-0.237]). The Cox regression models revealed that a higher total TFPI activity, above 97.5th percentile of the reference group, was associated with an increased mortality risk (hazard ratio = 2.58 [95% confidence interval: 1.49-4.47]), independent of age, sex, and cardiovascular risk profile.CONCLUSION: In the Gutenberg Health Study population-based cohort, the highest percentage of total TFPI correlated with an increased mortality risk. While elevated TFPI may reflect endothelial cell activation, the associations between total TFPI activity and obesity and CAD, points to additional mechanistic interactions.

AB - OBJECTIVE: Tissue factor pathway inhibitor (TFPI) is a potent anticoagulant protein in the extrinsic coagulation pathway. In the present study, we aim to identify the cardiovascular determinants for total TFPI activity and its association with cardiovascular disease (CVD) and total mortality.METHODS: Total TFPI activity was assessed in a selection of the population-based Gutenberg Health Study (n = 5,000). Statistical analysis was performed to identify the determinants for total TFPI activity as well as the associations with CVD and mortality.RESULTS: Multivariable linear regression analysis identified smoking (β 0.095 [0.054-0.136]) as a positive determinant for total TFPI activity, while diabetes (β -0.072 [-0.134 to -0.009]), obesity (β -0.063 [-0.101 to -0.024]), and history of coronary artery disease (CAD) were negatively associated with total TFPI activity, independent of age, sex, and the remaining cardiovascular risk factors. After adjustment for lipoprotein levels, the association between total TFPI activity levels and obesity and CAD was lost. The analysis additionally revealed a strong positive association between total TFPI activity levels and low-density lipoprotein (β 0.221 [0.204-0.237]). The Cox regression models revealed that a higher total TFPI activity, above 97.5th percentile of the reference group, was associated with an increased mortality risk (hazard ratio = 2.58 [95% confidence interval: 1.49-4.47]), independent of age, sex, and cardiovascular risk profile.CONCLUSION: In the Gutenberg Health Study population-based cohort, the highest percentage of total TFPI correlated with an increased mortality risk. While elevated TFPI may reflect endothelial cell activation, the associations between total TFPI activity and obesity and CAD, points to additional mechanistic interactions.

U2 - 10.1055/s-0040-1715897

DO - 10.1055/s-0040-1715897

M3 - SCORING: Journal article

C2 - 32877953

VL - 121

SP - 174

EP - 181

JO - THROMB HAEMOSTASIS

JF - THROMB HAEMOSTASIS

SN - 0340-6245

IS - 2

ER -