Relation between biomarkers in exhaled breath condensate and internal exposure to metals from gas metal arc welding.
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Relation between biomarkers in exhaled breath condensate and internal exposure to metals from gas metal arc welding. / Hoffmeyer, Frank; Raulf-Heimsoth, Monika; Weiss, Tobias; Lehnert, Martin; Gawrych, Katarzyna; Kendzia, Benjamin; Harth, Volker; Henry, Jana; Pesch, Beate; Brüning, Thomas; Group, WELDOX Study.
In: J Breath Res, Vol. 6, No. 2, 2, 2012, p. 27105.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Relation between biomarkers in exhaled breath condensate and internal exposure to metals from gas metal arc welding.
AU - Hoffmeyer, Frank
AU - Raulf-Heimsoth, Monika
AU - Weiss, Tobias
AU - Lehnert, Martin
AU - Gawrych, Katarzyna
AU - Kendzia, Benjamin
AU - Harth, Volker
AU - Henry, Jana
AU - Pesch, Beate
AU - Brüning, Thomas
AU - Group, WELDOX Study
PY - 2012
Y1 - 2012
N2 - Concerning possible harmful components of welding fumes, besides gases and quantitative aspects of the respirable welding fumes, particle-inherent metal toxicity has to be considered.The objective of this study was to investigate the effect markers leukotriene B4 (LTB4),prostaglandin E2 (PGE2) and 8-isoprostane (8-Iso PGF2?) as well as the acid–base balance(pH) in exhaled breath condensate (EBC) of 43 full-time gas metal arc welders (20 smokers) in relation to welding fume exposure. We observed different patterns of iron, chromium and nickel in respirable welding fumes and EBC. Welders with undetectable chromium in EBC(group A, n = 24) presented high iron and nickel concentrations. In this group, higher 8-isoPGF2? and LTB4 concentrations could be revealed compared to welders with detectable chromium and low levels of both iron and nickel in EBC (group B): 8-iso PGF2?443.3 pg mL?1 versus 247.2 pg mL?1; p = 0.001 and LTB4 30.5 pg mL?1 versus 17.3 pgmL?1; p = 0.016. EBC-pH was more acid in samples of group B (6.52 versus 6.82; p = 0.011).Overall, effect markers in welders were associated with iron concentrations in EBC according to smoking habits--non-smokers/smokers: LTB4 (rs = 0.48; p = 0.02/rs = 0.21; p = 0.37),PGE2 (rs = 0.15; p = 0.59/rs = 0.47; p = 0.07), 8-iso PGF2? (rs = 0.18; p = 0.54/rs = 0.59;p = 0.06). Sampling of EBC in occupational research provides a matrix for the simultaneous monitoring of metal exposure and effects on target level. Our results suggest irritative effects in the airways of healthy welders. Further studies are necessary to assess whether these individual results might be used to identify welders at elevated risk for developing a respiratory disease.
AB - Concerning possible harmful components of welding fumes, besides gases and quantitative aspects of the respirable welding fumes, particle-inherent metal toxicity has to be considered.The objective of this study was to investigate the effect markers leukotriene B4 (LTB4),prostaglandin E2 (PGE2) and 8-isoprostane (8-Iso PGF2?) as well as the acid–base balance(pH) in exhaled breath condensate (EBC) of 43 full-time gas metal arc welders (20 smokers) in relation to welding fume exposure. We observed different patterns of iron, chromium and nickel in respirable welding fumes and EBC. Welders with undetectable chromium in EBC(group A, n = 24) presented high iron and nickel concentrations. In this group, higher 8-isoPGF2? and LTB4 concentrations could be revealed compared to welders with detectable chromium and low levels of both iron and nickel in EBC (group B): 8-iso PGF2?443.3 pg mL?1 versus 247.2 pg mL?1; p = 0.001 and LTB4 30.5 pg mL?1 versus 17.3 pgmL?1; p = 0.016. EBC-pH was more acid in samples of group B (6.52 versus 6.82; p = 0.011).Overall, effect markers in welders were associated with iron concentrations in EBC according to smoking habits--non-smokers/smokers: LTB4 (rs = 0.48; p = 0.02/rs = 0.21; p = 0.37),PGE2 (rs = 0.15; p = 0.59/rs = 0.47; p = 0.07), 8-iso PGF2? (rs = 0.18; p = 0.54/rs = 0.59;p = 0.06). Sampling of EBC in occupational research provides a matrix for the simultaneous monitoring of metal exposure and effects on target level. Our results suggest irritative effects in the airways of healthy welders. Further studies are necessary to assess whether these individual results might be used to identify welders at elevated risk for developing a respiratory disease.
KW - Adult
KW - Humans
KW - Male
KW - Middle Aged
KW - Young Adult
KW - Cross-Sectional Studies
KW - Incidence
KW - Germany/epidemiology
KW - Biological Markers/analysis
KW - Exhalation
KW - Air Pollutants, Occupational/adverse effects/analysis
KW - Metals/analysis
KW - Occupational Diseases/diagnosis/metabolism
KW - Occupational Exposure/analysis
KW - Welding
KW - Adult
KW - Humans
KW - Male
KW - Middle Aged
KW - Young Adult
KW - Cross-Sectional Studies
KW - Incidence
KW - Germany/epidemiology
KW - Biological Markers/analysis
KW - Exhalation
KW - Air Pollutants, Occupational/adverse effects/analysis
KW - Metals/analysis
KW - Occupational Diseases/diagnosis/metabolism
KW - Occupational Exposure/analysis
KW - Welding
M3 - SCORING: Journal article
VL - 6
SP - 27105
JO - J BREATH RES
JF - J BREATH RES
SN - 1752-7155
IS - 2
M1 - 2
ER -
