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Re-irradiation of spinal cord compression due to metastasis in elderly patients

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Re-irradiation of spinal cord compression due to metastasis in elderly patients. / Rades, Dirk; Evers, Jasmin N; Bajrovic, Amira; Veninga, Theo; Schild, Steven E.

In: ANTICANCER RES, Vol. 34, No. 5, 05.2014, p. 2555-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rades, D, Evers, JN, Bajrovic, A, Veninga, T & Schild, SE 2014, 'Re-irradiation of spinal cord compression due to metastasis in elderly patients', ANTICANCER RES, vol. 34, no. 5, pp. 2555-8.

APA

Rades, D., Evers, J. N., Bajrovic, A., Veninga, T., & Schild, S. E. (2014). Re-irradiation of spinal cord compression due to metastasis in elderly patients. ANTICANCER RES, 34(5), 2555-8.

Vancouver

Rades D, Evers JN, Bajrovic A, Veninga T, Schild SE. Re-irradiation of spinal cord compression due to metastasis in elderly patients. ANTICANCER RES. 2014 May;34(5):2555-8.

Bibtex

@article{520b84b776ef4fedb4ff4ba34c2f3946,
title = "Re-irradiation of spinal cord compression due to metastasis in elderly patients",
abstract = "BACKGROUND/AIM: The present study investigated efficacy and toxicity of re-irradiation for an in-field recurrence of spinal cord compression due to metastasis (SCCM) in elderly patients.PATIENTS AND METHODS: Data of 60 patients aged ≥65 years who were irradiated for an in-field recurrence of SCCM were retrospectively analyzed. The fractionation regimen of re-irradiation and eight additional potential prognostic factors were evaluated for motor function.RESULTS: Median time to in-field recurrence was 6 (2-45) months. After re-irradiation, 25 patients (42%) showed improvement of motor function, 28 (47%) no change, and 7 (12%) deterioration. No second in-field recurrences were observed. Post-treatment motor function was not associated with the fractionation regimen. Radiation myelopathy was not observed. The cumulative biologically-effective dose for myelopathy was 80-137 Gy2.CONCLUSION: Re-irradiation for in-field recurrences of SCCM in elderly patients appears safe and effective. Myelopathy appears unlikely, if the cumulative biologically effective dose is 137 Gy2 or less. The fractionation regimen had no significant impact on motor function.",
keywords = "Aged, Aged, 80 and over, Dose Fractionation, Female, Humans, Male, Neoplasm Recurrence, Local, Radiotherapy, Retrospective Studies, Spinal Cord Compression, Spinal Neoplasms",
author = "Dirk Rades and Evers, {Jasmin N} and Amira Bajrovic and Theo Veninga and Schild, {Steven E}",
year = "2014",
month = may,
language = "English",
volume = "34",
pages = "2555--8",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Re-irradiation of spinal cord compression due to metastasis in elderly patients

AU - Rades, Dirk

AU - Evers, Jasmin N

AU - Bajrovic, Amira

AU - Veninga, Theo

AU - Schild, Steven E

PY - 2014/5

Y1 - 2014/5

N2 - BACKGROUND/AIM: The present study investigated efficacy and toxicity of re-irradiation for an in-field recurrence of spinal cord compression due to metastasis (SCCM) in elderly patients.PATIENTS AND METHODS: Data of 60 patients aged ≥65 years who were irradiated for an in-field recurrence of SCCM were retrospectively analyzed. The fractionation regimen of re-irradiation and eight additional potential prognostic factors were evaluated for motor function.RESULTS: Median time to in-field recurrence was 6 (2-45) months. After re-irradiation, 25 patients (42%) showed improvement of motor function, 28 (47%) no change, and 7 (12%) deterioration. No second in-field recurrences were observed. Post-treatment motor function was not associated with the fractionation regimen. Radiation myelopathy was not observed. The cumulative biologically-effective dose for myelopathy was 80-137 Gy2.CONCLUSION: Re-irradiation for in-field recurrences of SCCM in elderly patients appears safe and effective. Myelopathy appears unlikely, if the cumulative biologically effective dose is 137 Gy2 or less. The fractionation regimen had no significant impact on motor function.

AB - BACKGROUND/AIM: The present study investigated efficacy and toxicity of re-irradiation for an in-field recurrence of spinal cord compression due to metastasis (SCCM) in elderly patients.PATIENTS AND METHODS: Data of 60 patients aged ≥65 years who were irradiated for an in-field recurrence of SCCM were retrospectively analyzed. The fractionation regimen of re-irradiation and eight additional potential prognostic factors were evaluated for motor function.RESULTS: Median time to in-field recurrence was 6 (2-45) months. After re-irradiation, 25 patients (42%) showed improvement of motor function, 28 (47%) no change, and 7 (12%) deterioration. No second in-field recurrences were observed. Post-treatment motor function was not associated with the fractionation regimen. Radiation myelopathy was not observed. The cumulative biologically-effective dose for myelopathy was 80-137 Gy2.CONCLUSION: Re-irradiation for in-field recurrences of SCCM in elderly patients appears safe and effective. Myelopathy appears unlikely, if the cumulative biologically effective dose is 137 Gy2 or less. The fractionation regimen had no significant impact on motor function.

KW - Aged

KW - Aged, 80 and over

KW - Dose Fractionation

KW - Female

KW - Humans

KW - Male

KW - Neoplasm Recurrence, Local

KW - Radiotherapy

KW - Retrospective Studies

KW - Spinal Cord Compression

KW - Spinal Neoplasms

M3 - SCORING: Journal article

C2 - 24778076

VL - 34

SP - 2555

EP - 2558

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 5

ER -