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Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis

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Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis. / Pagel, J; Hartz, A; Figge, J; Gille, C; Eschweiler, S; Petersen, K; Schreiter, L; Hammer, J; Karsten, C M; Friedrich, D; Herting, E; Göpel, W; Rupp, J; Härtel, C.

In: CLIN EXP IMMUNOL, Vol. 185, No. 2, 08.2016, p. 219-27.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pagel, J, Hartz, A, Figge, J, Gille, C, Eschweiler, S, Petersen, K, Schreiter, L, Hammer, J, Karsten, CM, Friedrich, D, Herting, E, Göpel, W, Rupp, J & Härtel, C 2016, 'Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis', CLIN EXP IMMUNOL, vol. 185, no. 2, pp. 219-27. https://doi.org/10.1111/cei.12810

APA

Pagel, J., Hartz, A., Figge, J., Gille, C., Eschweiler, S., Petersen, K., Schreiter, L., Hammer, J., Karsten, C. M., Friedrich, D., Herting, E., Göpel, W., Rupp, J., & Härtel, C. (2016). Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis. CLIN EXP IMMUNOL, 185(2), 219-27. https://doi.org/10.1111/cei.12810

Vancouver

Pagel J, Hartz A, Figge J, Gille C, Eschweiler S, Petersen K et al. Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis. CLIN EXP IMMUNOL. 2016 Aug;185(2):219-27. https://doi.org/10.1111/cei.12810

Bibtex

@article{1a4d87756a3e4d0c85cd9f26e7c55d0a,
title = "Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis",
abstract = "The predisposition of preterm neonates to invasive infection is, as yet, incompletely understood. Regulatory T cells (Tregs ) are potential candidates for the ontogenetic control of immune activation and tissue damage in preterm infants. It was the aim of our study to characterize lymphocyte subsets and in particular CD4(+) CD25(+) forkhead box protein 3 (FoxP3)(+) Tregs in peripheral blood of well-phenotyped preterm infants (n = 117; 23 + 0 - 36 + 6 weeks of gestational age) in the first 3 days of life in comparison to term infants and adults. We demonstrated a negative correlation of Treg frequencies and gestational age. Tregs were increased in blood samples of preterm infants compared to term infants and adults. Notably, we found an increased Treg frequency in preterm infants with clinical early-onset sepsis while cause of preterm delivery, e.g. chorioamnionitis, did not affect Treg frequencies. Our data suggest that Tregs apparently play an important role in maintaining maternal-fetal tolerance, which turns into an increased sepsis risk after preterm delivery. Functional analyses are needed in order to elucidate whether Tregs have potential as future target for diagnostics and therapeutics.",
keywords = "Adult, Amnion/microbiology, Chorioamnionitis/immunology, Female, Forkhead Transcription Factors/blood, Gestational Age, Humans, Immune Tolerance, Infant, Infant, Newborn, Infant, Premature/immunology, Infant, Premature, Diseases/immunology, Lymphocyte Subsets/cytology, Pregnancy, Sepsis/immunology, T-Lymphocytes, Regulatory/immunology",
author = "J Pagel and A Hartz and J Figge and C Gille and S Eschweiler and K Petersen and L Schreiter and J Hammer and Karsten, {C M} and D Friedrich and E Herting and W G{\"o}pel and J Rupp and C H{\"a}rtel",
note = "{\textcopyright} 2016 British Society for Immunology.",
year = "2016",
month = aug,
doi = "10.1111/cei.12810",
language = "English",
volume = "185",
pages = "219--27",
journal = "CLIN EXP IMMUNOL",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis

AU - Pagel, J

AU - Hartz, A

AU - Figge, J

AU - Gille, C

AU - Eschweiler, S

AU - Petersen, K

AU - Schreiter, L

AU - Hammer, J

AU - Karsten, C M

AU - Friedrich, D

AU - Herting, E

AU - Göpel, W

AU - Rupp, J

AU - Härtel, C

N1 - © 2016 British Society for Immunology.

PY - 2016/8

Y1 - 2016/8

N2 - The predisposition of preterm neonates to invasive infection is, as yet, incompletely understood. Regulatory T cells (Tregs ) are potential candidates for the ontogenetic control of immune activation and tissue damage in preterm infants. It was the aim of our study to characterize lymphocyte subsets and in particular CD4(+) CD25(+) forkhead box protein 3 (FoxP3)(+) Tregs in peripheral blood of well-phenotyped preterm infants (n = 117; 23 + 0 - 36 + 6 weeks of gestational age) in the first 3 days of life in comparison to term infants and adults. We demonstrated a negative correlation of Treg frequencies and gestational age. Tregs were increased in blood samples of preterm infants compared to term infants and adults. Notably, we found an increased Treg frequency in preterm infants with clinical early-onset sepsis while cause of preterm delivery, e.g. chorioamnionitis, did not affect Treg frequencies. Our data suggest that Tregs apparently play an important role in maintaining maternal-fetal tolerance, which turns into an increased sepsis risk after preterm delivery. Functional analyses are needed in order to elucidate whether Tregs have potential as future target for diagnostics and therapeutics.

AB - The predisposition of preterm neonates to invasive infection is, as yet, incompletely understood. Regulatory T cells (Tregs ) are potential candidates for the ontogenetic control of immune activation and tissue damage in preterm infants. It was the aim of our study to characterize lymphocyte subsets and in particular CD4(+) CD25(+) forkhead box protein 3 (FoxP3)(+) Tregs in peripheral blood of well-phenotyped preterm infants (n = 117; 23 + 0 - 36 + 6 weeks of gestational age) in the first 3 days of life in comparison to term infants and adults. We demonstrated a negative correlation of Treg frequencies and gestational age. Tregs were increased in blood samples of preterm infants compared to term infants and adults. Notably, we found an increased Treg frequency in preterm infants with clinical early-onset sepsis while cause of preterm delivery, e.g. chorioamnionitis, did not affect Treg frequencies. Our data suggest that Tregs apparently play an important role in maintaining maternal-fetal tolerance, which turns into an increased sepsis risk after preterm delivery. Functional analyses are needed in order to elucidate whether Tregs have potential as future target for diagnostics and therapeutics.

KW - Adult

KW - Amnion/microbiology

KW - Chorioamnionitis/immunology

KW - Female

KW - Forkhead Transcription Factors/blood

KW - Gestational Age

KW - Humans

KW - Immune Tolerance

KW - Infant

KW - Infant, Newborn

KW - Infant, Premature/immunology

KW - Infant, Premature, Diseases/immunology

KW - Lymphocyte Subsets/cytology

KW - Pregnancy

KW - Sepsis/immunology

KW - T-Lymphocytes, Regulatory/immunology

U2 - 10.1111/cei.12810

DO - 10.1111/cei.12810

M3 - SCORING: Journal article

C2 - 27163159

VL - 185

SP - 219

EP - 227

JO - CLIN EXP IMMUNOL

JF - CLIN EXP IMMUNOL

SN - 0009-9104

IS - 2

ER -