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Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

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Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. / Marengère, L E; Waterhouse, P; Duncan, G S; Mittrücker, H W; Feng, G S; Mak, T W.

In: SCIENCE, Vol. 272, No. 5265, 24.05.1996, p. 1170-3.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Marengère, LE, Waterhouse, P, Duncan, GS, Mittrücker, HW, Feng, GS & Mak, TW 1996, 'Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4', SCIENCE, vol. 272, no. 5265, pp. 1170-3.

APA

Marengère, L. E., Waterhouse, P., Duncan, G. S., Mittrücker, H. W., Feng, G. S., & Mak, T. W. (1996). Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. SCIENCE, 272(5265), 1170-3.

Vancouver

Marengère LE, Waterhouse P, Duncan GS, Mittrücker HW, Feng GS, Mak TW. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. SCIENCE. 1996 May 24;272(5265):1170-3.

Bibtex

@article{a7819abc2590489cba8dcf9ce9833fd4,
title = "Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4",
abstract = "The absence of CTLA-4 results in uncontrolled T cell proliferation. The T cell receptor-specific kinases FYN, LCK, and ZAP-70 as well as the RAS pathway were found to be activated in T cells of Ctla-4-/- mutant mice. In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, an interaction mediated by the SRC homology 2 (SH2) domains of SYP and the phosphotyrosine sequence Tyr-Val-Lys-Met within the CTLA-4 cytoplasmic tail. The CTLA-4-associated SYP had phosphatase activity toward the RAS regulator p52SHC. Thus, the RAS pathway and T cell activation through the T cell receptor are regulated by CTLA-4-associated SYP.",
keywords = "Adaptor Proteins, Signal Transducing, Adaptor Proteins, Vesicular Transport, Amino Acid Sequence, Animals, Antigens, CD, Antigens, CD3, Antigens, Differentiation, CTLA-4 Antigen, GRB2 Adaptor Protein, Immunoconjugates, Intracellular Signaling Peptides and Proteins, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Mutation, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Protein Tyrosine Phosphatases, Protein-Tyrosine Kinases, Proteins, Receptors, Antigen, B-Cell, Receptors, Antigen, T-Cell, Recombinant Fusion Proteins, SH2 Domain-Containing Protein Tyrosine Phosphatases, Shc Signaling Adaptor Proteins, Signal Transduction, T-Lymphocytes, ras Proteins, src Homology Domains",
author = "Mareng{\`e}re, {L E} and P Waterhouse and Duncan, {G S} and Mittr{\"u}cker, {H W} and Feng, {G S} and Mak, {T W}",
year = "1996",
month = may,
day = "24",
language = "English",
volume = "272",
pages = "1170--3",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5265",

}

RIS

TY - JOUR

T1 - Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

AU - Marengère, L E

AU - Waterhouse, P

AU - Duncan, G S

AU - Mittrücker, H W

AU - Feng, G S

AU - Mak, T W

PY - 1996/5/24

Y1 - 1996/5/24

N2 - The absence of CTLA-4 results in uncontrolled T cell proliferation. The T cell receptor-specific kinases FYN, LCK, and ZAP-70 as well as the RAS pathway were found to be activated in T cells of Ctla-4-/- mutant mice. In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, an interaction mediated by the SRC homology 2 (SH2) domains of SYP and the phosphotyrosine sequence Tyr-Val-Lys-Met within the CTLA-4 cytoplasmic tail. The CTLA-4-associated SYP had phosphatase activity toward the RAS regulator p52SHC. Thus, the RAS pathway and T cell activation through the T cell receptor are regulated by CTLA-4-associated SYP.

AB - The absence of CTLA-4 results in uncontrolled T cell proliferation. The T cell receptor-specific kinases FYN, LCK, and ZAP-70 as well as the RAS pathway were found to be activated in T cells of Ctla-4-/- mutant mice. In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, an interaction mediated by the SRC homology 2 (SH2) domains of SYP and the phosphotyrosine sequence Tyr-Val-Lys-Met within the CTLA-4 cytoplasmic tail. The CTLA-4-associated SYP had phosphatase activity toward the RAS regulator p52SHC. Thus, the RAS pathway and T cell activation through the T cell receptor are regulated by CTLA-4-associated SYP.

KW - Adaptor Proteins, Signal Transducing

KW - Adaptor Proteins, Vesicular Transport

KW - Amino Acid Sequence

KW - Animals

KW - Antigens, CD

KW - Antigens, CD3

KW - Antigens, Differentiation

KW - CTLA-4 Antigen

KW - GRB2 Adaptor Protein

KW - Immunoconjugates

KW - Intracellular Signaling Peptides and Proteins

KW - Lymphocyte Activation

KW - Mice

KW - Mice, Inbred C57BL

KW - Molecular Sequence Data

KW - Mutation

KW - Phosphorylation

KW - Protein Tyrosine Phosphatase, Non-Receptor Type 11

KW - Protein Tyrosine Phosphatase, Non-Receptor Type 6

KW - Protein Tyrosine Phosphatases

KW - Protein-Tyrosine Kinases

KW - Proteins

KW - Receptors, Antigen, B-Cell

KW - Receptors, Antigen, T-Cell

KW - Recombinant Fusion Proteins

KW - SH2 Domain-Containing Protein Tyrosine Phosphatases

KW - Shc Signaling Adaptor Proteins

KW - Signal Transduction

KW - T-Lymphocytes

KW - ras Proteins

KW - src Homology Domains

M3 - SCORING: Journal article

C2 - 8638161

VL - 272

SP - 1170

EP - 1173

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 5265

ER -