Regulation of Bone Metabolism by microRNAs

Hanna Taipaleenmäki

doi:10.1007/s11914-018-0417-0

Regulation of Bone Metabolism by microRNAs

Standard

Regulation of Bone Metabolism by microRNAs. / Taipaleenmäki, Hanna.

In: CURR OSTEOPOROS REP, Vol. 16, No. 1, 02.2018, p. 1-12.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Taipaleenmäki, H 2018, 'Regulation of Bone Metabolism by microRNAs', CURR OSTEOPOROS REP, vol. 16, no. 1, pp. 1-12. https://doi.org/10.1007/s11914-018-0417-0

APA

Taipaleenmäki, H. (2018). Regulation of Bone Metabolism by microRNAs. CURR OSTEOPOROS REP, 16(1), 1-12. https://doi.org/10.1007/s11914-018-0417-0

Vancouver

Taipaleenmäki H. Regulation of Bone Metabolism by microRNAs. CURR OSTEOPOROS REP. 2018 Feb;16(1):1-12. https://doi.org/10.1007/s11914-018-0417-0

Bibtex

@article{8d0501ec82854480bc0077a9ed2ecc3c,

title = "Regulation of Bone Metabolism by microRNAs",

abstract = "PURPOSE OF REVIEW: The small non-coding microRNAs (miRNAs) have emerged as important post-transcriptional regulators of various physiological and pathological processes. The purpose of this article is to review the important recent advances on the role of miRNAs in bone remodeling and metabolic bone disorders.RECENT FINDINGS: In a physiological context, miRNAs regulate bone formation and bone resorption, thereby contributing to the maintenance of bone homeostasis. Under pathological conditions, an aberrant miRNA signaling contributes to the onset and progression of skeletal disorders, such as osteoporosis. Furthermore, miRNAs can be secreted to circulation and have clinical potential as non-invasive biomarkers. In a therapeutic setting, miRNA delivery or antagonism has been reported to affect several diseases under pre-clinical conditions thereby emerging as novel pharmacological tools. miRNAs are key regulators of bone remodeling in health and disease. The future perspectives in the field include the role of secreted miRNAs in cell-cell communication in the bone environment. Furthermore, the clinical potential of using miRNAs as diagnostic tools and therapeutic targets to treat metabolic bone diseases provides an attractive future direction.",

keywords = "Journal Article, Review",

author = "Hanna Taipaleenm{\"a}ki",

year = "2018",

month = feb,

doi = "10.1007/s11914-018-0417-0",

language = "English",

volume = "16",

pages = "1--12",

journal = "CURR OSTEOPOROS REP",

issn = "1544-1873",

publisher = "SPRINGER US",

number = "1",

}

RIS

TY - JOUR

T1 - Regulation of Bone Metabolism by microRNAs

AU - Taipaleenmäki, Hanna

PY - 2018/2

Y1 - 2018/2

N2 - PURPOSE OF REVIEW: The small non-coding microRNAs (miRNAs) have emerged as important post-transcriptional regulators of various physiological and pathological processes. The purpose of this article is to review the important recent advances on the role of miRNAs in bone remodeling and metabolic bone disorders.RECENT FINDINGS: In a physiological context, miRNAs regulate bone formation and bone resorption, thereby contributing to the maintenance of bone homeostasis. Under pathological conditions, an aberrant miRNA signaling contributes to the onset and progression of skeletal disorders, such as osteoporosis. Furthermore, miRNAs can be secreted to circulation and have clinical potential as non-invasive biomarkers. In a therapeutic setting, miRNA delivery or antagonism has been reported to affect several diseases under pre-clinical conditions thereby emerging as novel pharmacological tools. miRNAs are key regulators of bone remodeling in health and disease. The future perspectives in the field include the role of secreted miRNAs in cell-cell communication in the bone environment. Furthermore, the clinical potential of using miRNAs as diagnostic tools and therapeutic targets to treat metabolic bone diseases provides an attractive future direction.

AB - PURPOSE OF REVIEW: The small non-coding microRNAs (miRNAs) have emerged as important post-transcriptional regulators of various physiological and pathological processes. The purpose of this article is to review the important recent advances on the role of miRNAs in bone remodeling and metabolic bone disorders.RECENT FINDINGS: In a physiological context, miRNAs regulate bone formation and bone resorption, thereby contributing to the maintenance of bone homeostasis. Under pathological conditions, an aberrant miRNA signaling contributes to the onset and progression of skeletal disorders, such as osteoporosis. Furthermore, miRNAs can be secreted to circulation and have clinical potential as non-invasive biomarkers. In a therapeutic setting, miRNA delivery or antagonism has been reported to affect several diseases under pre-clinical conditions thereby emerging as novel pharmacological tools. miRNAs are key regulators of bone remodeling in health and disease. The future perspectives in the field include the role of secreted miRNAs in cell-cell communication in the bone environment. Furthermore, the clinical potential of using miRNAs as diagnostic tools and therapeutic targets to treat metabolic bone diseases provides an attractive future direction.

KW - Journal Article

KW - Review

U2 - 10.1007/s11914-018-0417-0

DO - 10.1007/s11914-018-0417-0

M3 - SCORING: Review article

C2 - 29335833

VL - 16

SP - 1

EP - 12

JO - CURR OSTEOPOROS REP

JF - CURR OSTEOPOROS REP

SN - 1544-1873

IS - 1

ER -