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Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group

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Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group. / Sackmann, M; Morgner, A; Rudolph, B; Neubauer, A; Thiede, C; Schulz, H; Kraemer, W; Boersch, G; Rohde, P; Seifert, E; Stolte, M; Bayerdoerffer, E.

In: GASTROENTEROLOGY, Vol. 113, No. 4, 10.1997, p. 1087-90.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sackmann, M, Morgner, A, Rudolph, B, Neubauer, A, Thiede, C, Schulz, H, Kraemer, W, Boersch, G, Rohde, P, Seifert, E, Stolte, M & Bayerdoerffer, E 1997, 'Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group', GASTROENTEROLOGY, vol. 113, no. 4, pp. 1087-90.

APA

Sackmann, M., Morgner, A., Rudolph, B., Neubauer, A., Thiede, C., Schulz, H., Kraemer, W., Boersch, G., Rohde, P., Seifert, E., Stolte, M., & Bayerdoerffer, E. (1997). Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group. GASTROENTEROLOGY, 113(4), 1087-90.

Vancouver

Sackmann M, Morgner A, Rudolph B, Neubauer A, Thiede C, Schulz H et al. Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group. GASTROENTEROLOGY. 1997 Oct;113(4):1087-90.

Bibtex

@article{f91296705b694303a69948a40ba144d7,
title = "Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group",
abstract = "BACKGROUND & AIMS: Recent studies suggest that eradication of Helicobacter pylori may result in complete regression of low-grade lymphoma of the gastric mucosa-associated lymphoid tissue (MALT). Which patients benefit from this treatment is unknown. The aim of this study was to prospectively study whether staging by echoendoscopy predicts the outcome of treatment of MALT lymphoma by eradication of H. pylori.METHODS: Twenty-two patients positive for H. pylori with low-grade gastric B-cell MALT lymphoma were examined by echoendoscopy at the time of diagnosis. Treatment for H. pylori consisted of a 2-week course of oral omeprazole and amoxicillin. Patients were followed up by endoscopy and biopsy.RESULTS: H. pylori was eradicated in all patients. Complete regression of MALT lymphoma was observed in 12 patients (54%), partial regression in 5 patients (23%), and no response in 5 patients (23%) during follow-up. Twelve of 14 patients with lymphoma restricted to the mucosa or submucosa (stage E-I1) at echoendoscopy, but none of the 10 patients with higher stage (P < 0.01), showed complete regression of MALT lymphoma. In stage E-I1 patients, the probability of complete regression of lymphoma was 60% at 6, 79% at 12, and reached 100% at 14 months, respectively.CONCLUSIONS: Staging of gastric low-grade MALT lymphomas by endoscopic ultrasonography allows prediction of the response to therapy by eradication of H. pylori.",
keywords = "Adult, Aged, Aged, 80 and over, Amoxicillin, Anti-Ulcer Agents, Endoscopy, Endosonography, Female, Follow-Up Studies, Helicobacter Infections, Helicobacter pylori, Humans, Lymphoma, B-Cell, Marginal Zone, Male, Middle Aged, Neoplasm Staging, Omeprazole, Penicillins, Predictive Value of Tests, Stomach Neoplasms, Time Factors, Journal Article",
author = "M Sackmann and A Morgner and B Rudolph and A Neubauer and C Thiede and H Schulz and W Kraemer and G Boersch and P Rohde and E Seifert and M Stolte and E Bayerdoerffer",
year = "1997",
month = oct,
language = "English",
volume = "113",
pages = "1087--90",
journal = "GASTROENTEROLOGY",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group

AU - Sackmann, M

AU - Morgner, A

AU - Rudolph, B

AU - Neubauer, A

AU - Thiede, C

AU - Schulz, H

AU - Kraemer, W

AU - Boersch, G

AU - Rohde, P

AU - Seifert, E

AU - Stolte, M

AU - Bayerdoerffer, E

PY - 1997/10

Y1 - 1997/10

N2 - BACKGROUND & AIMS: Recent studies suggest that eradication of Helicobacter pylori may result in complete regression of low-grade lymphoma of the gastric mucosa-associated lymphoid tissue (MALT). Which patients benefit from this treatment is unknown. The aim of this study was to prospectively study whether staging by echoendoscopy predicts the outcome of treatment of MALT lymphoma by eradication of H. pylori.METHODS: Twenty-two patients positive for H. pylori with low-grade gastric B-cell MALT lymphoma were examined by echoendoscopy at the time of diagnosis. Treatment for H. pylori consisted of a 2-week course of oral omeprazole and amoxicillin. Patients were followed up by endoscopy and biopsy.RESULTS: H. pylori was eradicated in all patients. Complete regression of MALT lymphoma was observed in 12 patients (54%), partial regression in 5 patients (23%), and no response in 5 patients (23%) during follow-up. Twelve of 14 patients with lymphoma restricted to the mucosa or submucosa (stage E-I1) at echoendoscopy, but none of the 10 patients with higher stage (P < 0.01), showed complete regression of MALT lymphoma. In stage E-I1 patients, the probability of complete regression of lymphoma was 60% at 6, 79% at 12, and reached 100% at 14 months, respectively.CONCLUSIONS: Staging of gastric low-grade MALT lymphomas by endoscopic ultrasonography allows prediction of the response to therapy by eradication of H. pylori.

AB - BACKGROUND & AIMS: Recent studies suggest that eradication of Helicobacter pylori may result in complete regression of low-grade lymphoma of the gastric mucosa-associated lymphoid tissue (MALT). Which patients benefit from this treatment is unknown. The aim of this study was to prospectively study whether staging by echoendoscopy predicts the outcome of treatment of MALT lymphoma by eradication of H. pylori.METHODS: Twenty-two patients positive for H. pylori with low-grade gastric B-cell MALT lymphoma were examined by echoendoscopy at the time of diagnosis. Treatment for H. pylori consisted of a 2-week course of oral omeprazole and amoxicillin. Patients were followed up by endoscopy and biopsy.RESULTS: H. pylori was eradicated in all patients. Complete regression of MALT lymphoma was observed in 12 patients (54%), partial regression in 5 patients (23%), and no response in 5 patients (23%) during follow-up. Twelve of 14 patients with lymphoma restricted to the mucosa or submucosa (stage E-I1) at echoendoscopy, but none of the 10 patients with higher stage (P < 0.01), showed complete regression of MALT lymphoma. In stage E-I1 patients, the probability of complete regression of lymphoma was 60% at 6, 79% at 12, and reached 100% at 14 months, respectively.CONCLUSIONS: Staging of gastric low-grade MALT lymphomas by endoscopic ultrasonography allows prediction of the response to therapy by eradication of H. pylori.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Amoxicillin

KW - Anti-Ulcer Agents

KW - Endoscopy

KW - Endosonography

KW - Female

KW - Follow-Up Studies

KW - Helicobacter Infections

KW - Helicobacter pylori

KW - Humans

KW - Lymphoma, B-Cell, Marginal Zone

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Omeprazole

KW - Penicillins

KW - Predictive Value of Tests

KW - Stomach Neoplasms

KW - Time Factors

KW - Journal Article

M3 - SCORING: Journal article

C2 - 9322502

VL - 113

SP - 1087

EP - 1090

JO - GASTROENTEROLOGY

JF - GASTROENTEROLOGY

SN - 0016-5085

IS - 4

ER -