Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging
Standard
Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging. / Kolb, Christoph; Wetscherek, Andreas; Buzan, Maria Teodora; Werner, René; Rank, Christopher M; Kachelrie, Marc; Kreuter, Michael; Dinkel, Julien; Heuel, Claus Peter; Maier-Hein, Klaus.
In: J COMPUT ASSIST TOMO, Vol. 40, No. 6, 11.2016, p. 899-906.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging
AU - Kolb, Christoph
AU - Wetscherek, Andreas
AU - Buzan, Maria Teodora
AU - Werner, René
AU - Rank, Christopher M
AU - Kachelrie, Marc
AU - Kreuter, Michael
AU - Dinkel, Julien
AU - Heuel, Claus Peter
AU - Maier-Hein, Klaus
PY - 2016/11
Y1 - 2016/11
N2 - OBJECTIVE: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI).METHODS: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR images of patients with lung fibrosis; 4D MR ventilation maps were compared with corresponding diagnostic 3D CT images of the patients and 4D CT maps of subjects without impaired lung function (serving as reference).RESULTS: Comparison between the computed patient-specific 4D MR regional ventilation maps and diagnostic CT images shows good correlation in conspicuous regions. Comparison to 4D CT-derived ventilation maps supports the plausibility of the 4D MR maps. Dynamic MRI-based flow-volume loops and spirograms further visualize the free-breathing behavior.CONCLUSIONS: The proposed methods allow for 4D MR-based regional analysis of tissue dynamics and ventilation in spontaneous breathing and comparison of patient data. The proposed atlas-based reference coordinate system provides an automated manner of annotating and comparing multimodal lung image data.
AB - OBJECTIVE: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI).METHODS: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR images of patients with lung fibrosis; 4D MR ventilation maps were compared with corresponding diagnostic 3D CT images of the patients and 4D CT maps of subjects without impaired lung function (serving as reference).RESULTS: Comparison between the computed patient-specific 4D MR regional ventilation maps and diagnostic CT images shows good correlation in conspicuous regions. Comparison to 4D CT-derived ventilation maps supports the plausibility of the 4D MR maps. Dynamic MRI-based flow-volume loops and spirograms further visualize the free-breathing behavior.CONCLUSIONS: The proposed methods allow for 4D MR-based regional analysis of tissue dynamics and ventilation in spontaneous breathing and comparison of patient data. The proposed atlas-based reference coordinate system provides an automated manner of annotating and comparing multimodal lung image data.
U2 - 10.1097/RCT.0000000000000450
DO - 10.1097/RCT.0000000000000450
M3 - SCORING: Journal article
C2 - 27331925
VL - 40
SP - 899
EP - 906
JO - J COMPUT ASSIST TOMO
JF - J COMPUT ASSIST TOMO
SN - 0363-8715
IS - 6
ER -
