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Regional and global right ventricular dysfunction in asymptomatic or minimally symptomatic patients with congenitally corrected transposition

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Regional and global right ventricular dysfunction in asymptomatic or minimally symptomatic patients with congenitally corrected transposition. / Tulevski, Igor I; Zijta, Frank M; Smeijers, Anika S; Dodge-Khatami, Ali; van der Wall, Ernst E; Mulder, Barbara J M.

In: CARDIOL YOUNG, Vol. 14, No. 2, 04.2004, p. 168-173.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tulevski, II, Zijta, FM, Smeijers, AS, Dodge-Khatami, A, van der Wall, EE & Mulder, BJM 2004, 'Regional and global right ventricular dysfunction in asymptomatic or minimally symptomatic patients with congenitally corrected transposition', CARDIOL YOUNG, vol. 14, no. 2, pp. 168-173. https://doi.org/10.1017/S1047951104002094

APA

Tulevski, I. I., Zijta, F. M., Smeijers, A. S., Dodge-Khatami, A., van der Wall, E. E., & Mulder, B. J. M. (2004). Regional and global right ventricular dysfunction in asymptomatic or minimally symptomatic patients with congenitally corrected transposition. CARDIOL YOUNG, 14(2), 168-173. https://doi.org/10.1017/S1047951104002094

Vancouver

Tulevski II, Zijta FM, Smeijers AS, Dodge-Khatami A, van der Wall EE, Mulder BJM. Regional and global right ventricular dysfunction in asymptomatic or minimally symptomatic patients with congenitally corrected transposition. CARDIOL YOUNG. 2004 Apr;14(2):168-173. https://doi.org/10.1017/S1047951104002094

Bibtex

@article{e9ef39da40fc48ae9964e0f1600030c3,
title = "Regional and global right ventricular dysfunction in asymptomatic or minimally symptomatic patients with congenitally corrected transposition",
abstract = "Patients with congenitally corrected transposition are at risk of right ventricular dysfunction and failure. With this in mind, we examined 13 patients with congenitally corrected transposition, 7 not having undergone surgery, and 6 after physiological repair, comparing them with 6 healthy subjects matched for age and sex, using cardiac magnetic resonance imaging, at rest and during dobutamine stress, in order to determine regional and global right ventricular response to stress. At rest, the patients had significantly decreased overall wall motion compared to their healthy peers (7.2 +/- 0.5, versus 9.8 +/- 0.4 mm). During infusion of dobutamine, overall wall motion increased to 12.8 +/- 0.4 mm in the healthy subjects, versus 8.8 +/- 1.0 mm in patients. At the regional level, significant differences in mural motion were found between patients and controls in the anterior (9.5 +/- 1.1, versus 13.2 +/- 0.6 mm), posterior (10.2 +/- 1.6, versus 13.2 +/- 0.8 mm), and septal segments (5.0 +/- 0.8, versus 11.2 +/- 0.6 mm). At rest, overall mural thickening in patients was similar to that of controls, but significantly less in patients during stress. During dobutamine stress, patients showed significantly less regional wall thickening than controls, particularly in the septal (2.7 +/- 0.6, versus 6.0 +/- 0.4 mm, respectively) and in the anterior segments (4.2 +/- 0.6, versus 7.8 +/- 0.6 mm, respectively). Right ventricular ejection fraction strongly correlated with mural motion and thickening, both at rest and during stress. Abnormal regional function in the systemic morphologically right ventricle may occur in patients with congenitally corrected transposition, which strongly correlates with right ventricular ejection fraction. Our findings support the hypothesis that, in patients with congenitally corrected transposition, ischemia of the right ventricular myocardium contributes to the development of right ventricular dysfunction.",
keywords = "Adult, Cardiac Surgical Procedures/adverse effects, Case-Control Studies, Dobutamine, Echocardiography, Doppler, Female, Heart Function Tests, Hemodynamics/physiology, Humans, Magnetic Resonance Imaging/methods, Male, Myocardial Contraction/physiology, Probability, Prognosis, Retrospective Studies, Risk Assessment, Severity of Illness Index, Stroke Volume/physiology, Transposition of Great Vessels/complications, Treatment Outcome, Ventricular Dysfunction, Right/diagnosis",
author = "Tulevski, {Igor I} and Zijta, {Frank M} and Smeijers, {Anika S} and Ali Dodge-Khatami and {van der Wall}, {Ernst E} and Mulder, {Barbara J M}",
year = "2004",
month = apr,
doi = "10.1017/S1047951104002094",
language = "English",
volume = "14",
pages = "168--173",
journal = "CARDIOL YOUNG",
issn = "1047-9511",
publisher = "Cambridge University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Regional and global right ventricular dysfunction in asymptomatic or minimally symptomatic patients with congenitally corrected transposition

AU - Tulevski, Igor I

AU - Zijta, Frank M

AU - Smeijers, Anika S

AU - Dodge-Khatami, Ali

AU - van der Wall, Ernst E

AU - Mulder, Barbara J M

PY - 2004/4

Y1 - 2004/4

N2 - Patients with congenitally corrected transposition are at risk of right ventricular dysfunction and failure. With this in mind, we examined 13 patients with congenitally corrected transposition, 7 not having undergone surgery, and 6 after physiological repair, comparing them with 6 healthy subjects matched for age and sex, using cardiac magnetic resonance imaging, at rest and during dobutamine stress, in order to determine regional and global right ventricular response to stress. At rest, the patients had significantly decreased overall wall motion compared to their healthy peers (7.2 +/- 0.5, versus 9.8 +/- 0.4 mm). During infusion of dobutamine, overall wall motion increased to 12.8 +/- 0.4 mm in the healthy subjects, versus 8.8 +/- 1.0 mm in patients. At the regional level, significant differences in mural motion were found between patients and controls in the anterior (9.5 +/- 1.1, versus 13.2 +/- 0.6 mm), posterior (10.2 +/- 1.6, versus 13.2 +/- 0.8 mm), and septal segments (5.0 +/- 0.8, versus 11.2 +/- 0.6 mm). At rest, overall mural thickening in patients was similar to that of controls, but significantly less in patients during stress. During dobutamine stress, patients showed significantly less regional wall thickening than controls, particularly in the septal (2.7 +/- 0.6, versus 6.0 +/- 0.4 mm, respectively) and in the anterior segments (4.2 +/- 0.6, versus 7.8 +/- 0.6 mm, respectively). Right ventricular ejection fraction strongly correlated with mural motion and thickening, both at rest and during stress. Abnormal regional function in the systemic morphologically right ventricle may occur in patients with congenitally corrected transposition, which strongly correlates with right ventricular ejection fraction. Our findings support the hypothesis that, in patients with congenitally corrected transposition, ischemia of the right ventricular myocardium contributes to the development of right ventricular dysfunction.

AB - Patients with congenitally corrected transposition are at risk of right ventricular dysfunction and failure. With this in mind, we examined 13 patients with congenitally corrected transposition, 7 not having undergone surgery, and 6 after physiological repair, comparing them with 6 healthy subjects matched for age and sex, using cardiac magnetic resonance imaging, at rest and during dobutamine stress, in order to determine regional and global right ventricular response to stress. At rest, the patients had significantly decreased overall wall motion compared to their healthy peers (7.2 +/- 0.5, versus 9.8 +/- 0.4 mm). During infusion of dobutamine, overall wall motion increased to 12.8 +/- 0.4 mm in the healthy subjects, versus 8.8 +/- 1.0 mm in patients. At the regional level, significant differences in mural motion were found between patients and controls in the anterior (9.5 +/- 1.1, versus 13.2 +/- 0.6 mm), posterior (10.2 +/- 1.6, versus 13.2 +/- 0.8 mm), and septal segments (5.0 +/- 0.8, versus 11.2 +/- 0.6 mm). At rest, overall mural thickening in patients was similar to that of controls, but significantly less in patients during stress. During dobutamine stress, patients showed significantly less regional wall thickening than controls, particularly in the septal (2.7 +/- 0.6, versus 6.0 +/- 0.4 mm, respectively) and in the anterior segments (4.2 +/- 0.6, versus 7.8 +/- 0.6 mm, respectively). Right ventricular ejection fraction strongly correlated with mural motion and thickening, both at rest and during stress. Abnormal regional function in the systemic morphologically right ventricle may occur in patients with congenitally corrected transposition, which strongly correlates with right ventricular ejection fraction. Our findings support the hypothesis that, in patients with congenitally corrected transposition, ischemia of the right ventricular myocardium contributes to the development of right ventricular dysfunction.

KW - Adult

KW - Cardiac Surgical Procedures/adverse effects

KW - Case-Control Studies

KW - Dobutamine

KW - Echocardiography, Doppler

KW - Female

KW - Heart Function Tests

KW - Hemodynamics/physiology

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Myocardial Contraction/physiology

KW - Probability

KW - Prognosis

KW - Retrospective Studies

KW - Risk Assessment

KW - Severity of Illness Index

KW - Stroke Volume/physiology

KW - Transposition of Great Vessels/complications

KW - Treatment Outcome

KW - Ventricular Dysfunction, Right/diagnosis

U2 - 10.1017/S1047951104002094

DO - 10.1017/S1047951104002094

M3 - SCORING: Journal article

C2 - 15691406

VL - 14

SP - 168

EP - 173

JO - CARDIOL YOUNG

JF - CARDIOL YOUNG

SN - 1047-9511

IS - 2

ER -