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Regenerative capacity of the enteric nervous system: is immaturity defining the point of no return?

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Regenerative capacity of the enteric nervous system: is immaturity defining the point of no return? / von Sochaczewski, Christina Oetzmann; Wenke, Katharina; Grieve, Andrew; Westgarth-Taylor, Chris; Loveland, Jerome Alexander; Metzger, Roman; Kluth, Dietrich.

In: J SURG RES, Vol. 209, 03.2017, p. 112-121.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

von Sochaczewski, CO, Wenke, K, Grieve, A, Westgarth-Taylor, C, Loveland, JA, Metzger, R & Kluth, D 2017, 'Regenerative capacity of the enteric nervous system: is immaturity defining the point of no return?', J SURG RES, vol. 209, pp. 112-121. https://doi.org/10.1016/j.jss.2016.09.035

APA

von Sochaczewski, C. O., Wenke, K., Grieve, A., Westgarth-Taylor, C., Loveland, J. A., Metzger, R., & Kluth, D. (2017). Regenerative capacity of the enteric nervous system: is immaturity defining the point of no return? J SURG RES, 209, 112-121. https://doi.org/10.1016/j.jss.2016.09.035

Vancouver

von Sochaczewski CO, Wenke K, Grieve A, Westgarth-Taylor C, Loveland JA, Metzger R et al. Regenerative capacity of the enteric nervous system: is immaturity defining the point of no return? J SURG RES. 2017 Mar;209:112-121. https://doi.org/10.1016/j.jss.2016.09.035

Bibtex

@article{65a926e6ef7e448a9805576d9e29ee7a,
title = "Regenerative capacity of the enteric nervous system: is immaturity defining the point of no return?",
abstract = "BACKGROUND: Intestinal obstruction in newborns is associated with intestinal motility disorders after surgery. Alterations in the enteric nervous system (ENS) might cause abnormal peristalsis, which may then result in intestinal motility disorders. We aimed to quantify alterations in the myenteric plexus after a ligation and to test if these alterations were reversible.METHODS: Small intestines of chicken embryos were ligated in ovo at embryonic day (ED) 11 for either 4 d (ED 11-15) or 8 d (ED 11-19). Both treated groups and control group were sacrificed and intestinal segments examined by means of both light and electron microscopy.RESULTS: The number of proximal myenteric ganglia increased (ED 19, 30.7 ± 3.16 versus 23.1 ± 2.03; P < 0.001) in the 8-d ligature group but had values similar to the control group in the 4-d ligature group. The size distribution was skewed toward small ganglia in the 8-d ligature group (ED 19, 83.71 ± 11.60% versus 3.88 ± 4.74% in the control group; P < 0.001) but comparable with the control group in the 4-d ligature group. Subcellular alterations in the 4-d ligature group were reversible.CONCLUSIONS: The pathologic alterations in the ENS were fully reversible in the 4-d ligature group. This reversibility might be linked to the degree of immaturity of the ENS.",
keywords = "Animals, Chick Embryo, Enteric Nervous System, Nerve Regeneration, Journal Article",
author = "{von Sochaczewski}, {Christina Oetzmann} and Katharina Wenke and Andrew Grieve and Chris Westgarth-Taylor and Loveland, {Jerome Alexander} and Roman Metzger and Dietrich Kluth",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2017",
month = mar,
doi = "10.1016/j.jss.2016.09.035",
language = "English",
volume = "209",
pages = "112--121",
journal = "J SURG RES",
issn = "0022-4804",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Regenerative capacity of the enteric nervous system: is immaturity defining the point of no return?

AU - von Sochaczewski, Christina Oetzmann

AU - Wenke, Katharina

AU - Grieve, Andrew

AU - Westgarth-Taylor, Chris

AU - Loveland, Jerome Alexander

AU - Metzger, Roman

AU - Kluth, Dietrich

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2017/3

Y1 - 2017/3

N2 - BACKGROUND: Intestinal obstruction in newborns is associated with intestinal motility disorders after surgery. Alterations in the enteric nervous system (ENS) might cause abnormal peristalsis, which may then result in intestinal motility disorders. We aimed to quantify alterations in the myenteric plexus after a ligation and to test if these alterations were reversible.METHODS: Small intestines of chicken embryos were ligated in ovo at embryonic day (ED) 11 for either 4 d (ED 11-15) or 8 d (ED 11-19). Both treated groups and control group were sacrificed and intestinal segments examined by means of both light and electron microscopy.RESULTS: The number of proximal myenteric ganglia increased (ED 19, 30.7 ± 3.16 versus 23.1 ± 2.03; P < 0.001) in the 8-d ligature group but had values similar to the control group in the 4-d ligature group. The size distribution was skewed toward small ganglia in the 8-d ligature group (ED 19, 83.71 ± 11.60% versus 3.88 ± 4.74% in the control group; P < 0.001) but comparable with the control group in the 4-d ligature group. Subcellular alterations in the 4-d ligature group were reversible.CONCLUSIONS: The pathologic alterations in the ENS were fully reversible in the 4-d ligature group. This reversibility might be linked to the degree of immaturity of the ENS.

AB - BACKGROUND: Intestinal obstruction in newborns is associated with intestinal motility disorders after surgery. Alterations in the enteric nervous system (ENS) might cause abnormal peristalsis, which may then result in intestinal motility disorders. We aimed to quantify alterations in the myenteric plexus after a ligation and to test if these alterations were reversible.METHODS: Small intestines of chicken embryos were ligated in ovo at embryonic day (ED) 11 for either 4 d (ED 11-15) or 8 d (ED 11-19). Both treated groups and control group were sacrificed and intestinal segments examined by means of both light and electron microscopy.RESULTS: The number of proximal myenteric ganglia increased (ED 19, 30.7 ± 3.16 versus 23.1 ± 2.03; P < 0.001) in the 8-d ligature group but had values similar to the control group in the 4-d ligature group. The size distribution was skewed toward small ganglia in the 8-d ligature group (ED 19, 83.71 ± 11.60% versus 3.88 ± 4.74% in the control group; P < 0.001) but comparable with the control group in the 4-d ligature group. Subcellular alterations in the 4-d ligature group were reversible.CONCLUSIONS: The pathologic alterations in the ENS were fully reversible in the 4-d ligature group. This reversibility might be linked to the degree of immaturity of the ENS.

KW - Animals

KW - Chick Embryo

KW - Enteric Nervous System

KW - Nerve Regeneration

KW - Journal Article

U2 - 10.1016/j.jss.2016.09.035

DO - 10.1016/j.jss.2016.09.035

M3 - SCORING: Journal article

C2 - 28032547

VL - 209

SP - 112

EP - 121

JO - J SURG RES

JF - J SURG RES

SN - 0022-4804

ER -