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Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus.

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Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. / Förster, Eckart; Tielsch, Albrecht; Saum, Barbara; Weiss, Karl Heinz; Johanssen, Celine; Graus-Porta, Diana; Müller, Ulrich; Frotscher, Michael.

In: P NATL ACAD SCI USA, Vol. 99, No. 20, 20, 2002, p. 13178-13183.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Förster, E, Tielsch, A, Saum, B, Weiss, KH, Johanssen, C, Graus-Porta, D, Müller, U & Frotscher, M 2002, 'Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus.', P NATL ACAD SCI USA, vol. 99, no. 20, 20, pp. 13178-13183. <http://www.ncbi.nlm.nih.gov/pubmed/12244214?dopt=Citation>

APA

Förster, E., Tielsch, A., Saum, B., Weiss, K. H., Johanssen, C., Graus-Porta, D., Müller, U., & Frotscher, M. (2002). Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. P NATL ACAD SCI USA, 99(20), 13178-13183. [20]. http://www.ncbi.nlm.nih.gov/pubmed/12244214?dopt=Citation

Vancouver

Förster E, Tielsch A, Saum B, Weiss KH, Johanssen C, Graus-Porta D et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. P NATL ACAD SCI USA. 2002;99(20):13178-13183. 20.

Bibtex

@article{ff60e53457424329a0005588131d0881,
title = "Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus.",
abstract = "The extracellular matrix molecule Reelin is required for the correct positioning of neurons during the development of the forebrain. However, the mechanism of Reelin action on neuronal migration is poorly understood. Reelin is assumed to act on neurons directly, but it may also affect the differentiation of glial cells necessary for neuronal migration. Here we show that a regular glial scaffold fails to form in vivo in the dentate gyrus of mice deficient of Reelin or Disabled 1, a neuronal adaptor protein in the Reelin signaling pathway. A subset of these defects is observed in mice that lack beta(1)-class integrins, known to bind Reelin. Moreover, recombinant Reelin induced branching of glial processes in vitro. Our data suggest that Reelin affects glial differentiation via Disabled 1 and beta(1)-class integrin-dependent signaling pathways.",
author = "Eckart F{\"o}rster and Albrecht Tielsch and Barbara Saum and Weiss, {Karl Heinz} and Celine Johanssen and Diana Graus-Porta and Ulrich M{\"u}ller and Michael Frotscher",
year = "2002",
language = "Deutsch",
volume = "99",
pages = "13178--13183",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "20",

}

RIS

TY - JOUR

T1 - Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus.

AU - Förster, Eckart

AU - Tielsch, Albrecht

AU - Saum, Barbara

AU - Weiss, Karl Heinz

AU - Johanssen, Celine

AU - Graus-Porta, Diana

AU - Müller, Ulrich

AU - Frotscher, Michael

PY - 2002

Y1 - 2002

N2 - The extracellular matrix molecule Reelin is required for the correct positioning of neurons during the development of the forebrain. However, the mechanism of Reelin action on neuronal migration is poorly understood. Reelin is assumed to act on neurons directly, but it may also affect the differentiation of glial cells necessary for neuronal migration. Here we show that a regular glial scaffold fails to form in vivo in the dentate gyrus of mice deficient of Reelin or Disabled 1, a neuronal adaptor protein in the Reelin signaling pathway. A subset of these defects is observed in mice that lack beta(1)-class integrins, known to bind Reelin. Moreover, recombinant Reelin induced branching of glial processes in vitro. Our data suggest that Reelin affects glial differentiation via Disabled 1 and beta(1)-class integrin-dependent signaling pathways.

AB - The extracellular matrix molecule Reelin is required for the correct positioning of neurons during the development of the forebrain. However, the mechanism of Reelin action on neuronal migration is poorly understood. Reelin is assumed to act on neurons directly, but it may also affect the differentiation of glial cells necessary for neuronal migration. Here we show that a regular glial scaffold fails to form in vivo in the dentate gyrus of mice deficient of Reelin or Disabled 1, a neuronal adaptor protein in the Reelin signaling pathway. A subset of these defects is observed in mice that lack beta(1)-class integrins, known to bind Reelin. Moreover, recombinant Reelin induced branching of glial processes in vitro. Our data suggest that Reelin affects glial differentiation via Disabled 1 and beta(1)-class integrin-dependent signaling pathways.

M3 - SCORING: Zeitschriftenaufsatz

VL - 99

SP - 13178

EP - 13183

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 20

M1 - 20

ER -