Reduction of Relapse after Unrelated Donor Stem Cell Transplantation by KIR-Based Graft Selection
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Reduction of Relapse after Unrelated Donor Stem Cell Transplantation by KIR-Based Graft Selection. / Heidenreich, Silke; Kröger, Nicolaus.
In: FRONT IMMUNOL, Vol. 8, 2017, p. 41.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Reduction of Relapse after Unrelated Donor Stem Cell Transplantation by KIR-Based Graft Selection
AU - Heidenreich, Silke
AU - Kröger, Nicolaus
PY - 2017
Y1 - 2017
N2 - Besides donor T cells, natural killer (NK) cells are considered to have a major role in preventing relapse after allogeneic hematopoietic stem cell transplantation (HSCT). After T-cell-depleted haploidentical HSCT, a strong NK alloreactivity has been described. These effects have been attributed to killer-cell immunoglobulin-like receptors (KIR). Abundant reports suggest a major role of KIR not only on outcome after haploidentical HSCT but also in the unrelated donor setting. In this review, we give a brief overview of the mechanism of NK cell activation, nomenclature of KIR haplotypes, human leukocyte antigen (HLA) groups, and distinct models for prediction of NK cell alloreactivity. It can be concluded that KIR-ligand mismatch seems to provoke adverse effects in unrelated donor HSCT with reduced overall survival and increased risk for high-grade acute graft-versus-host disease. The presence of activating KIR, as seen in KIR haplotype B, as well as the patient's HLA C1/x haplotype might reduce relapse in myeloid malignancies.
AB - Besides donor T cells, natural killer (NK) cells are considered to have a major role in preventing relapse after allogeneic hematopoietic stem cell transplantation (HSCT). After T-cell-depleted haploidentical HSCT, a strong NK alloreactivity has been described. These effects have been attributed to killer-cell immunoglobulin-like receptors (KIR). Abundant reports suggest a major role of KIR not only on outcome after haploidentical HSCT but also in the unrelated donor setting. In this review, we give a brief overview of the mechanism of NK cell activation, nomenclature of KIR haplotypes, human leukocyte antigen (HLA) groups, and distinct models for prediction of NK cell alloreactivity. It can be concluded that KIR-ligand mismatch seems to provoke adverse effects in unrelated donor HSCT with reduced overall survival and increased risk for high-grade acute graft-versus-host disease. The presence of activating KIR, as seen in KIR haplotype B, as well as the patient's HLA C1/x haplotype might reduce relapse in myeloid malignancies.
KW - Journal Article
KW - Review
U2 - 10.3389/fimmu.2017.00041
DO - 10.3389/fimmu.2017.00041
M3 - SCORING: Review article
C2 - 28228753
VL - 8
SP - 41
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
ER -