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Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

Standard

Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls. / Buchert, Ralph; Kluge, Andreas; Tossici-Bolt, Livia; Dickson, John; Bronzel, Marcus; Lange, Catharina; Asenbaum, Susanne; Booij, Jan; Atay Kapucu, L Özlem; Svarer, Claus; Koulibaly, Pierre-Malick; Nobili, Flavio; Pagani, Marco; Sabri, Osama; Sera, Terez; Tatsch, Klaus; Vander Borght, Thierry; Van Laere, Koen; Varrone, Andrea; Iida, Hidehiro.

In: EUR J NUCL MED MOL I, Vol. 43, No. 7, 07.2016, p. 1323-36.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Buchert, R, Kluge, A, Tossici-Bolt, L, Dickson, J, Bronzel, M, Lange, C, Asenbaum, S, Booij, J, Atay Kapucu, LÖ, Svarer, C, Koulibaly, P-M, Nobili, F, Pagani, M, Sabri, O, Sera, T, Tatsch, K, Vander Borght, T, Van Laere, K, Varrone, A & Iida, H 2016, 'Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls', EUR J NUCL MED MOL I, vol. 43, no. 7, pp. 1323-36. https://doi.org/10.1007/s00259-016-3309-5

APA

Buchert, R., Kluge, A., Tossici-Bolt, L., Dickson, J., Bronzel, M., Lange, C., Asenbaum, S., Booij, J., Atay Kapucu, L. Ö., Svarer, C., Koulibaly, P-M., Nobili, F., Pagani, M., Sabri, O., Sera, T., Tatsch, K., Vander Borght, T., Van Laere, K., Varrone, A., & Iida, H. (2016). Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls. EUR J NUCL MED MOL I, 43(7), 1323-36. https://doi.org/10.1007/s00259-016-3309-5

Vancouver

Buchert R, Kluge A, Tossici-Bolt L, Dickson J, Bronzel M, Lange C et al. Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls. EUR J NUCL MED MOL I. 2016 Jul;43(7):1323-36. https://doi.org/10.1007/s00259-016-3309-5

Bibtex

@article{06f5fc1158224e3dbede8f6e1b8513b0,
title = "Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls",
abstract = "PURPOSE: Quantitative estimates of dopamine transporter availability, determined with [(123)I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [(123)I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis.METHODS: Of 73 healthy subjects from the European Normal Control Database of [(123)I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific {"}to kBq/ml{"} calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [(123)I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occipital cortex or cerebellum as the reference. The correlation between SBR and age was used as the primary quality measure.RESULTS: The fraction of SBR variability explained by age was highest (1) with QSPECT, independently of the reference region, and (2) with whole brain as the reference, independently of the reconstruction algorithm.CONCLUSION: QSPECT reconstruction appears to be useful for reduction of camera-specific intersubject variability of [(123)I]FP-CIT SPECT in multisite and single-site multicamera settings. Whole brain excluding striatal binding as the reference provides more stable quantitative estimates than occipital or cerebellar binding.",
keywords = "Age Factors, Databases, Factual, Dopamine Plasma Membrane Transport Proteins/metabolism, Europe, Healthy Volunteers, Humans, Image Processing, Computer-Assisted/methods, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon/instrumentation, Tropanes/metabolism",
author = "Ralph Buchert and Andreas Kluge and Livia Tossici-Bolt and John Dickson and Marcus Bronzel and Catharina Lange and Susanne Asenbaum and Jan Booij and {Atay Kapucu}, {L {\"O}zlem} and Claus Svarer and Pierre-Malick Koulibaly and Flavio Nobili and Marco Pagani and Osama Sabri and Terez Sera and Klaus Tatsch and {Vander Borght}, Thierry and {Van Laere}, Koen and Andrea Varrone and Hidehiro Iida",
year = "2016",
month = jul,
doi = "10.1007/s00259-016-3309-5",
language = "English",
volume = "43",
pages = "1323--36",
journal = "EUR J NUCL MED MOL I",
issn = "1619-7070",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

AU - Buchert, Ralph

AU - Kluge, Andreas

AU - Tossici-Bolt, Livia

AU - Dickson, John

AU - Bronzel, Marcus

AU - Lange, Catharina

AU - Asenbaum, Susanne

AU - Booij, Jan

AU - Atay Kapucu, L Özlem

AU - Svarer, Claus

AU - Koulibaly, Pierre-Malick

AU - Nobili, Flavio

AU - Pagani, Marco

AU - Sabri, Osama

AU - Sera, Terez

AU - Tatsch, Klaus

AU - Vander Borght, Thierry

AU - Van Laere, Koen

AU - Varrone, Andrea

AU - Iida, Hidehiro

PY - 2016/7

Y1 - 2016/7

N2 - PURPOSE: Quantitative estimates of dopamine transporter availability, determined with [(123)I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [(123)I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis.METHODS: Of 73 healthy subjects from the European Normal Control Database of [(123)I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific "to kBq/ml" calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [(123)I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occipital cortex or cerebellum as the reference. The correlation between SBR and age was used as the primary quality measure.RESULTS: The fraction of SBR variability explained by age was highest (1) with QSPECT, independently of the reference region, and (2) with whole brain as the reference, independently of the reconstruction algorithm.CONCLUSION: QSPECT reconstruction appears to be useful for reduction of camera-specific intersubject variability of [(123)I]FP-CIT SPECT in multisite and single-site multicamera settings. Whole brain excluding striatal binding as the reference provides more stable quantitative estimates than occipital or cerebellar binding.

AB - PURPOSE: Quantitative estimates of dopamine transporter availability, determined with [(123)I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [(123)I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis.METHODS: Of 73 healthy subjects from the European Normal Control Database of [(123)I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific "to kBq/ml" calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [(123)I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occipital cortex or cerebellum as the reference. The correlation between SBR and age was used as the primary quality measure.RESULTS: The fraction of SBR variability explained by age was highest (1) with QSPECT, independently of the reference region, and (2) with whole brain as the reference, independently of the reconstruction algorithm.CONCLUSION: QSPECT reconstruction appears to be useful for reduction of camera-specific intersubject variability of [(123)I]FP-CIT SPECT in multisite and single-site multicamera settings. Whole brain excluding striatal binding as the reference provides more stable quantitative estimates than occipital or cerebellar binding.

KW - Age Factors

KW - Databases, Factual

KW - Dopamine Plasma Membrane Transport Proteins/metabolism

KW - Europe

KW - Healthy Volunteers

KW - Humans

KW - Image Processing, Computer-Assisted/methods

KW - Sensitivity and Specificity

KW - Tomography, Emission-Computed, Single-Photon/instrumentation

KW - Tropanes/metabolism

U2 - 10.1007/s00259-016-3309-5

DO - 10.1007/s00259-016-3309-5

M3 - SCORING: Journal article

C2 - 26816194

VL - 43

SP - 1323

EP - 1336

JO - EUR J NUCL MED MOL I

JF - EUR J NUCL MED MOL I

SN - 1619-7070

IS - 7

ER -