Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder

Simone Kühn; Christian Kaufmann; Daniela Simon; Tanja Endrass; Jürgen Gallinat; Norbert Kathmann

doi:10.1016/j.cortex.2012.09.001

Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder

Standard

Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder. / Kühn, Simone; Kaufmann, Christian; Simon, Daniela; Endrass, Tanja; Gallinat, Jürgen; Kathmann, Norbert.

In: CORTEX, Vol. 49, No. 8, 01.09.2013, p. 2178-85.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kühn, S, Kaufmann, C, Simon, D, Endrass, T, Gallinat, J & Kathmann, N 2013, 'Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder', CORTEX, vol. 49, no. 8, pp. 2178-85. https://doi.org/10.1016/j.cortex.2012.09.001

APA

Kühn, S., Kaufmann, C., Simon, D., Endrass, T., Gallinat, J., & Kathmann, N. (2013). Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder. CORTEX, 49(8), 2178-85. https://doi.org/10.1016/j.cortex.2012.09.001

Vancouver

Kühn S, Kaufmann C, Simon D, Endrass T, Gallinat J, Kathmann N. Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder. CORTEX. 2013 Sep 1;49(8):2178-85. https://doi.org/10.1016/j.cortex.2012.09.001

Bibtex

@article{74c73f7096b040e38c71541758a2f254,

title = "Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder",

abstract = "INTRODUCTION: Obsessive-compulsive disorder (OCD) is characterized by a pattern of repetitive, intrusive thoughts and behaviours that patients do not want to but feel they have to perform. Functional brain imaging revealed dysfunctional pathways in OCD involving the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal ganglia. Structural alterations in OCD have been discussed but analysis tools focussing on specific morphometric aspects such as cortical thickness have rarely been employed.METHODS: We acquired MRI scans from 101 OCD patients and 95 healthy control subjects. FreeSurfer analysis software was employed to model the individual grey-white and pial surfaces to compute cortical thickness as our target measure.RESULTS: Relative to controls, OCD patients demonstrate cortical thinning in dorsal and subgenual ACC (false discovery rate corrected at p < .001), as well as in several other regions within the fronto-parietal network (false discovery rate corrected at p < .05). Cortical thickness could not be predicted in whole brain analyses from symptom state, but there was a modest correlation of left dorsal ACC thickness with the obsession subscore of the Yale-Brown Obsessive-Compulsive Scale as well as with the Beck Depression Inventory score.CONCLUSIONS: The findings confirm and extend previous reports showing that OCD is associated with morphometric alterations. The location of the most robust cortical thinning in ACC regions matches the previously reported topography of functional alterations at resting state and during cognitive task execution.",

keywords = "Adult, Brain Mapping, Case-Control Studies, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Nerve Fibers, Unmyelinated, Obsessive-Compulsive Disorder, Organ Size, Severity of Illness Index, Young Adult",

author = "Simone K{\"u}hn and Christian Kaufmann and Daniela Simon and Tanja Endrass and J{\"u}rgen Gallinat and Norbert Kathmann",

year = "2013",

month = sep,

day = "1",

doi = "10.1016/j.cortex.2012.09.001",

language = "English",

volume = "49",

pages = "2178--85",

journal = "CORTEX",

issn = "0010-9452",

publisher = "Masson SpA",

number = "8",

}

RIS

TY - JOUR

T1 - Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder

AU - Kühn, Simone

AU - Kaufmann, Christian

AU - Simon, Daniela

AU - Endrass, Tanja

AU - Gallinat, Jürgen

AU - Kathmann, Norbert

PY - 2013/9/1

Y1 - 2013/9/1

N2 - INTRODUCTION: Obsessive-compulsive disorder (OCD) is characterized by a pattern of repetitive, intrusive thoughts and behaviours that patients do not want to but feel they have to perform. Functional brain imaging revealed dysfunctional pathways in OCD involving the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal ganglia. Structural alterations in OCD have been discussed but analysis tools focussing on specific morphometric aspects such as cortical thickness have rarely been employed.METHODS: We acquired MRI scans from 101 OCD patients and 95 healthy control subjects. FreeSurfer analysis software was employed to model the individual grey-white and pial surfaces to compute cortical thickness as our target measure.RESULTS: Relative to controls, OCD patients demonstrate cortical thinning in dorsal and subgenual ACC (false discovery rate corrected at p < .001), as well as in several other regions within the fronto-parietal network (false discovery rate corrected at p < .05). Cortical thickness could not be predicted in whole brain analyses from symptom state, but there was a modest correlation of left dorsal ACC thickness with the obsession subscore of the Yale-Brown Obsessive-Compulsive Scale as well as with the Beck Depression Inventory score.CONCLUSIONS: The findings confirm and extend previous reports showing that OCD is associated with morphometric alterations. The location of the most robust cortical thinning in ACC regions matches the previously reported topography of functional alterations at resting state and during cognitive task execution.

AB - INTRODUCTION: Obsessive-compulsive disorder (OCD) is characterized by a pattern of repetitive, intrusive thoughts and behaviours that patients do not want to but feel they have to perform. Functional brain imaging revealed dysfunctional pathways in OCD involving the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal ganglia. Structural alterations in OCD have been discussed but analysis tools focussing on specific morphometric aspects such as cortical thickness have rarely been employed.METHODS: We acquired MRI scans from 101 OCD patients and 95 healthy control subjects. FreeSurfer analysis software was employed to model the individual grey-white and pial surfaces to compute cortical thickness as our target measure.RESULTS: Relative to controls, OCD patients demonstrate cortical thinning in dorsal and subgenual ACC (false discovery rate corrected at p < .001), as well as in several other regions within the fronto-parietal network (false discovery rate corrected at p < .05). Cortical thickness could not be predicted in whole brain analyses from symptom state, but there was a modest correlation of left dorsal ACC thickness with the obsession subscore of the Yale-Brown Obsessive-Compulsive Scale as well as with the Beck Depression Inventory score.CONCLUSIONS: The findings confirm and extend previous reports showing that OCD is associated with morphometric alterations. The location of the most robust cortical thinning in ACC regions matches the previously reported topography of functional alterations at resting state and during cognitive task execution.

KW - Adult

KW - Brain Mapping

KW - Case-Control Studies

KW - Female

KW - Gyrus Cinguli

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Nerve Fibers, Myelinated

KW - Nerve Fibers, Unmyelinated

KW - Obsessive-Compulsive Disorder

KW - Organ Size

KW - Severity of Illness Index

KW - Young Adult

U2 - 10.1016/j.cortex.2012.09.001

DO - 10.1016/j.cortex.2012.09.001

M3 - SCORING: Journal article

C2 - 23067727

VL - 49

SP - 2178

EP - 2185

JO - CORTEX

JF - CORTEX

SN - 0010-9452

IS - 8

ER -