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Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic Disorder

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Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic Disorder. / Rentzsch, Johannes; Thoma, Lars; Gaudlitz, Katharina; Tänzer, Nicole; Gallinat, Jürgen; Kathmann, Norbert; Ströhle, Andreas; Plag, Jens.

In: NEUROPSYCHOBIOLOGY, Vol. 78, No. 1, 2019, p. 31-37.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rentzsch, J, Thoma, L, Gaudlitz, K, Tänzer, N, Gallinat, J, Kathmann, N, Ströhle, A & Plag, J 2019, 'Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic Disorder', NEUROPSYCHOBIOLOGY, vol. 78, no. 1, pp. 31-37. https://doi.org/10.1159/000498867

APA

Rentzsch, J., Thoma, L., Gaudlitz, K., Tänzer, N., Gallinat, J., Kathmann, N., Ströhle, A., & Plag, J. (2019). Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic Disorder. NEUROPSYCHOBIOLOGY, 78(1), 31-37. https://doi.org/10.1159/000498867

Vancouver

Rentzsch J, Thoma L, Gaudlitz K, Tänzer N, Gallinat J, Kathmann N et al. Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic Disorder. NEUROPSYCHOBIOLOGY. 2019;78(1):31-37. https://doi.org/10.1159/000498867

Bibtex

@article{8930808b41a34df9abd417a11171d491,
title = "Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic Disorder",
abstract = "Panic disorder (PD) is associated with increased body vigilance and reduced cognitive resources directed at non-fear-related stimuli, particularly in the absence of stimulus-rich environments. To date, only few studies have investigated whether this deficit in PD is reflected in reduced mismatch negativity (MMN), an event-related potential indexing preattentive sensitivity to unexpected stimulus changes. We tested 35 patients affected by PD and 42 matched healthy controls in an oddball paradigm, using frequency and duration deviant stimuli to measure auditory MMN. PD patients displayed reduced duration MMN amplitudes in comparison to healthy controls. No group differences were detected for duration MMN latency, as well as frequency MMN indices. Results support the notion of reduced processing of non-fear-related stimuli in PD patients, particularly with regard to the preattentive processing of sound duration deviants. Additionally, our findings are in line with clinical studies reporting divergent deficits in preattentive processing of frequency and duration deviants.",
keywords = "Adult, Attention/physiology, Auditory Perception/physiology, Brain/physiopathology, Electroencephalography, Female, Humans, Male, Panic Disorder/physiopathology",
author = "Johannes Rentzsch and Lars Thoma and Katharina Gaudlitz and Nicole T{\"a}nzer and J{\"u}rgen Gallinat and Norbert Kathmann and Andreas Str{\"o}hle and Jens Plag",
note = "{\textcopyright} 2019 S. Karger AG, Basel.",
year = "2019",
doi = "10.1159/000498867",
language = "English",
volume = "78",
pages = "31--37",
journal = "NEUROPSYCHOBIOLOGY",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic Disorder

AU - Rentzsch, Johannes

AU - Thoma, Lars

AU - Gaudlitz, Katharina

AU - Tänzer, Nicole

AU - Gallinat, Jürgen

AU - Kathmann, Norbert

AU - Ströhle, Andreas

AU - Plag, Jens

N1 - © 2019 S. Karger AG, Basel.

PY - 2019

Y1 - 2019

N2 - Panic disorder (PD) is associated with increased body vigilance and reduced cognitive resources directed at non-fear-related stimuli, particularly in the absence of stimulus-rich environments. To date, only few studies have investigated whether this deficit in PD is reflected in reduced mismatch negativity (MMN), an event-related potential indexing preattentive sensitivity to unexpected stimulus changes. We tested 35 patients affected by PD and 42 matched healthy controls in an oddball paradigm, using frequency and duration deviant stimuli to measure auditory MMN. PD patients displayed reduced duration MMN amplitudes in comparison to healthy controls. No group differences were detected for duration MMN latency, as well as frequency MMN indices. Results support the notion of reduced processing of non-fear-related stimuli in PD patients, particularly with regard to the preattentive processing of sound duration deviants. Additionally, our findings are in line with clinical studies reporting divergent deficits in preattentive processing of frequency and duration deviants.

AB - Panic disorder (PD) is associated with increased body vigilance and reduced cognitive resources directed at non-fear-related stimuli, particularly in the absence of stimulus-rich environments. To date, only few studies have investigated whether this deficit in PD is reflected in reduced mismatch negativity (MMN), an event-related potential indexing preattentive sensitivity to unexpected stimulus changes. We tested 35 patients affected by PD and 42 matched healthy controls in an oddball paradigm, using frequency and duration deviant stimuli to measure auditory MMN. PD patients displayed reduced duration MMN amplitudes in comparison to healthy controls. No group differences were detected for duration MMN latency, as well as frequency MMN indices. Results support the notion of reduced processing of non-fear-related stimuli in PD patients, particularly with regard to the preattentive processing of sound duration deviants. Additionally, our findings are in line with clinical studies reporting divergent deficits in preattentive processing of frequency and duration deviants.

KW - Adult

KW - Attention/physiology

KW - Auditory Perception/physiology

KW - Brain/physiopathology

KW - Electroencephalography

KW - Female

KW - Humans

KW - Male

KW - Panic Disorder/physiopathology

U2 - 10.1159/000498867

DO - 10.1159/000498867

M3 - SCORING: Journal article

C2 - 30947222

VL - 78

SP - 31

EP - 37

JO - NEUROPSYCHOBIOLOGY

JF - NEUROPSYCHOBIOLOGY

SN - 0302-282X

IS - 1

ER -