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Reduced heart rate response after premature ventricular contraction depending on severity of atrial fibrillation symptoms - Analysis on heart rate turbulence in atrial fibrillation patients

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Reduced heart rate response after premature ventricular contraction depending on severity of atrial fibrillation symptoms - Analysis on heart rate turbulence in atrial fibrillation patients. / Makimoto, Hisaki; Blockhaus, Christian; Meyer, Christian; Lin, Tina; Jungen, Christiane; Eickholt, Christian; Clasen, Lukas; Schmidt, Jan; Kurt, Muhammed; Müller, Patrick; Shin, Dong-In; Kelm, Malte; Fürnkranz, Alexander.

In: IJC HEART VASC, Vol. 18, 03.2018, p. 33-38.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Makimoto, H, Blockhaus, C, Meyer, C, Lin, T, Jungen, C, Eickholt, C, Clasen, L, Schmidt, J, Kurt, M, Müller, P, Shin, D-I, Kelm, M & Fürnkranz, A 2018, 'Reduced heart rate response after premature ventricular contraction depending on severity of atrial fibrillation symptoms - Analysis on heart rate turbulence in atrial fibrillation patients', IJC HEART VASC, vol. 18, pp. 33-38. https://doi.org/10.1016/j.ijcha.2018.02.004

APA

Makimoto, H., Blockhaus, C., Meyer, C., Lin, T., Jungen, C., Eickholt, C., Clasen, L., Schmidt, J., Kurt, M., Müller, P., Shin, D-I., Kelm, M., & Fürnkranz, A. (2018). Reduced heart rate response after premature ventricular contraction depending on severity of atrial fibrillation symptoms - Analysis on heart rate turbulence in atrial fibrillation patients. IJC HEART VASC, 18, 33-38. https://doi.org/10.1016/j.ijcha.2018.02.004

Vancouver

Makimoto H, Blockhaus C, Meyer C, Lin T, Jungen C, Eickholt C et al. Reduced heart rate response after premature ventricular contraction depending on severity of atrial fibrillation symptoms - Analysis on heart rate turbulence in atrial fibrillation patients. IJC HEART VASC. 2018 Mar;18:33-38. https://doi.org/10.1016/j.ijcha.2018.02.004

Bibtex

@article{5da4a54ab61c42f8952a130e8148eb58,
title = "Reduced heart rate response after premature ventricular contraction depending on severity of atrial fibrillation symptoms - Analysis on heart rate turbulence in atrial fibrillation patients",
abstract = "Background: The severity of symptoms during atrial fibrillation (AF) may be influenced by heart rate and blood pressure variation, due to irregular beats and the related adaptations in baroreflex sensitivity. This study investigated whether heart rate turbulence (HRT) as a reflection of baroreflex sensitivity is related to symptom severity during AF.Method: Ninety-seven patients (pts) who underwent electrophysiological study were enrolled. Consecutive 56 pts had paroxysmal AF (21 with milder symptoms [EHRA I or II; Group-M], 35 with severe symptoms [EHRA III or IV; Group-S]), and 41 age-matched controls without AF were included. After delivering a single ventricular extrastimulus during sinus rhythm and repeating the process 10 times, the quantification of HRT was performed by measuring turbulence onset (TO: heart rate acceleration) and turbulence slope (TS: rate of heart rate deceleration).Results: Group-M pts showed significantly diminished TO as compared to controls and Group-S pts (P = 0.012). There was no significant difference of the TS between the 3 groups. Given that a TO ≥ 0% or TS ≤ 2.5 ms/RR was considered abnormal, Group-M pts showed significantly higher incidences of abnormal HRT as compared to controls and Group-S pts (71% vs 40% vs 21%, respectively, P = 0.0012). Regression analysis demonstrated an independent and significant association between a diminished TO and milder AF symptoms (P < 0.05).Conclusions: The usual heart rate acceleration after premature ventricular contraction is significantly diminished in pts with milder AF symptoms as compared to pts with severe AF symptoms. The mechanism of association between this diminished response and symptoms should be further investigated.",
author = "Hisaki Makimoto and Christian Blockhaus and Christian Meyer and Tina Lin and Christiane Jungen and Christian Eickholt and Lukas Clasen and Jan Schmidt and Muhammed Kurt and Patrick M{\"u}ller and Dong-In Shin and Malte Kelm and Alexander F{\"u}rnkranz",
year = "2018",
month = mar,
doi = "10.1016/j.ijcha.2018.02.004",
language = "English",
volume = "18",
pages = "33--38",
journal = "IJC HEART VASC",
issn = "2352-9067",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Reduced heart rate response after premature ventricular contraction depending on severity of atrial fibrillation symptoms - Analysis on heart rate turbulence in atrial fibrillation patients

AU - Makimoto, Hisaki

AU - Blockhaus, Christian

AU - Meyer, Christian

AU - Lin, Tina

AU - Jungen, Christiane

AU - Eickholt, Christian

AU - Clasen, Lukas

AU - Schmidt, Jan

AU - Kurt, Muhammed

AU - Müller, Patrick

AU - Shin, Dong-In

AU - Kelm, Malte

AU - Fürnkranz, Alexander

PY - 2018/3

Y1 - 2018/3

N2 - Background: The severity of symptoms during atrial fibrillation (AF) may be influenced by heart rate and blood pressure variation, due to irregular beats and the related adaptations in baroreflex sensitivity. This study investigated whether heart rate turbulence (HRT) as a reflection of baroreflex sensitivity is related to symptom severity during AF.Method: Ninety-seven patients (pts) who underwent electrophysiological study were enrolled. Consecutive 56 pts had paroxysmal AF (21 with milder symptoms [EHRA I or II; Group-M], 35 with severe symptoms [EHRA III or IV; Group-S]), and 41 age-matched controls without AF were included. After delivering a single ventricular extrastimulus during sinus rhythm and repeating the process 10 times, the quantification of HRT was performed by measuring turbulence onset (TO: heart rate acceleration) and turbulence slope (TS: rate of heart rate deceleration).Results: Group-M pts showed significantly diminished TO as compared to controls and Group-S pts (P = 0.012). There was no significant difference of the TS between the 3 groups. Given that a TO ≥ 0% or TS ≤ 2.5 ms/RR was considered abnormal, Group-M pts showed significantly higher incidences of abnormal HRT as compared to controls and Group-S pts (71% vs 40% vs 21%, respectively, P = 0.0012). Regression analysis demonstrated an independent and significant association between a diminished TO and milder AF symptoms (P < 0.05).Conclusions: The usual heart rate acceleration after premature ventricular contraction is significantly diminished in pts with milder AF symptoms as compared to pts with severe AF symptoms. The mechanism of association between this diminished response and symptoms should be further investigated.

AB - Background: The severity of symptoms during atrial fibrillation (AF) may be influenced by heart rate and blood pressure variation, due to irregular beats and the related adaptations in baroreflex sensitivity. This study investigated whether heart rate turbulence (HRT) as a reflection of baroreflex sensitivity is related to symptom severity during AF.Method: Ninety-seven patients (pts) who underwent electrophysiological study were enrolled. Consecutive 56 pts had paroxysmal AF (21 with milder symptoms [EHRA I or II; Group-M], 35 with severe symptoms [EHRA III or IV; Group-S]), and 41 age-matched controls without AF were included. After delivering a single ventricular extrastimulus during sinus rhythm and repeating the process 10 times, the quantification of HRT was performed by measuring turbulence onset (TO: heart rate acceleration) and turbulence slope (TS: rate of heart rate deceleration).Results: Group-M pts showed significantly diminished TO as compared to controls and Group-S pts (P = 0.012). There was no significant difference of the TS between the 3 groups. Given that a TO ≥ 0% or TS ≤ 2.5 ms/RR was considered abnormal, Group-M pts showed significantly higher incidences of abnormal HRT as compared to controls and Group-S pts (71% vs 40% vs 21%, respectively, P = 0.0012). Regression analysis demonstrated an independent and significant association between a diminished TO and milder AF symptoms (P < 0.05).Conclusions: The usual heart rate acceleration after premature ventricular contraction is significantly diminished in pts with milder AF symptoms as compared to pts with severe AF symptoms. The mechanism of association between this diminished response and symptoms should be further investigated.

U2 - 10.1016/j.ijcha.2018.02.004

DO - 10.1016/j.ijcha.2018.02.004

M3 - SCORING: Journal article

C2 - 29876501

VL - 18

SP - 33

EP - 38

JO - IJC HEART VASC

JF - IJC HEART VASC

SN - 2352-9067

ER -