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Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle

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Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle. / Vezzoli, M.; Castellani, P.; Campana, L.; Corna, G.; Bosurgi, L.; Manfredi, A.A.; Bianchi, M.E.; Rubartelli, A.; Rovere-Querini, P.

In: ANN NY ACAD SCI, 2010, p. 83-90.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Vezzoli, M, Castellani, P, Campana, L, Corna, G, Bosurgi, L, Manfredi, AA, Bianchi, ME, Rubartelli, A & Rovere-Querini, P 2010, 'Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle', ANN NY ACAD SCI, pp. 83-90. https://doi.org/10.1111/j.1749-6632.2010.05748.x

APA

Vezzoli, M., Castellani, P., Campana, L., Corna, G., Bosurgi, L., Manfredi, A. A., Bianchi, M. E., Rubartelli, A., & Rovere-Querini, P. (2010). Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle. ANN NY ACAD SCI, 83-90. https://doi.org/10.1111/j.1749-6632.2010.05748.x

Vancouver

Vezzoli M, Castellani P, Campana L, Corna G, Bosurgi L, Manfredi AA et al. Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle. ANN NY ACAD SCI. 2010;83-90. https://doi.org/10.1111/j.1749-6632.2010.05748.x

Bibtex

@article{d513e1d5ea164503828e556ed1209f92,
title = "Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle",
abstract = "High-mobility group box-1 (HMGB1) is a prototypical endogenous signal that links tissue necrosis and wound healing. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage) while activating and recruiting stem cells, which foster tissue repair. However, little is known about the role environmental cues play in the extracellular functions of HMGB1. The skeletal muscle is an optimal tissue model to help us unravel these underlying molecular events. Here, sterile injury triggers a potent inflammatory response that includes infiltration by inflammatory leukocytes and the parallel activation, proliferation, and fusion of muscle-specific stem cells. Recent data suggest that the regulation of environmental redox is critical for the bioactivity of HMGB1, which is extremely sensitive to oxidation. Moreover, data suggest a potential role for infiltrating alternatively activated macrophages to influence the outcome of inflammatory responses to sterile skeletal muscle necrosis.",
author = "M. Vezzoli and P. Castellani and L. Campana and G. Corna and L. Bosurgi and A.A. Manfredi and M.E. Bianchi and A. Rubartelli and P. Rovere-Querini",
year = "2010",
doi = "10.1111/j.1749-6632.2010.05748.x",
language = "English",
pages = "83--90",
journal = "ANN NY ACAD SCI",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle

AU - Vezzoli, M.

AU - Castellani, P.

AU - Campana, L.

AU - Corna, G.

AU - Bosurgi, L.

AU - Manfredi, A.A.

AU - Bianchi, M.E.

AU - Rubartelli, A.

AU - Rovere-Querini, P.

PY - 2010

Y1 - 2010

N2 - High-mobility group box-1 (HMGB1) is a prototypical endogenous signal that links tissue necrosis and wound healing. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage) while activating and recruiting stem cells, which foster tissue repair. However, little is known about the role environmental cues play in the extracellular functions of HMGB1. The skeletal muscle is an optimal tissue model to help us unravel these underlying molecular events. Here, sterile injury triggers a potent inflammatory response that includes infiltration by inflammatory leukocytes and the parallel activation, proliferation, and fusion of muscle-specific stem cells. Recent data suggest that the regulation of environmental redox is critical for the bioactivity of HMGB1, which is extremely sensitive to oxidation. Moreover, data suggest a potential role for infiltrating alternatively activated macrophages to influence the outcome of inflammatory responses to sterile skeletal muscle necrosis.

AB - High-mobility group box-1 (HMGB1) is a prototypical endogenous signal that links tissue necrosis and wound healing. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage) while activating and recruiting stem cells, which foster tissue repair. However, little is known about the role environmental cues play in the extracellular functions of HMGB1. The skeletal muscle is an optimal tissue model to help us unravel these underlying molecular events. Here, sterile injury triggers a potent inflammatory response that includes infiltration by inflammatory leukocytes and the parallel activation, proliferation, and fusion of muscle-specific stem cells. Recent data suggest that the regulation of environmental redox is critical for the bioactivity of HMGB1, which is extremely sensitive to oxidation. Moreover, data suggest a potential role for infiltrating alternatively activated macrophages to influence the outcome of inflammatory responses to sterile skeletal muscle necrosis.

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-78049488758&partnerID=MN8TOARS

U2 - 10.1111/j.1749-6632.2010.05748.x

DO - 10.1111/j.1749-6632.2010.05748.x

M3 - SCORING: Review article

C2 - 20958320

SP - 83

EP - 90

JO - ANN NY ACAD SCI

JF - ANN NY ACAD SCI

SN - 0077-8923

ER -