Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network
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Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network. / Ludwig, Heinz; Boccadoro, Mario; Moreau, Philippe; San-Miguel, Jesus; Cavo, Michele; Pawlyn, Charlotte; Zweegman, Sonja; Facon, Thierry; Driessen, Christoph; Hajek, Roman; Dimopoulos, Melitios A; Gay, Francesca; Avet-Loiseau, Hervé; Terpos, Evangelos; Zojer, Niklas; Mohty, Mohamad; Mateos, Maria-Victoria; Einsele, Hermann; Delforge, Michel; Caers, Jo; Weisel, Katja; Jackson, Graham; Garderet, Laurent; Engelhardt, Monika; van de Donk, Niels; Leleu, Xavier; Goldschmidt, Hartmut; Beksac, Meral; Nijhof, Inger; Abildgaard, Niels; Bringhen, Sara; Sonneveld, Pieter.
In: LEUKEMIA, Vol. 35, No. 1, 01.2021, p. 31-44.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network
AU - Ludwig, Heinz
AU - Boccadoro, Mario
AU - Moreau, Philippe
AU - San-Miguel, Jesus
AU - Cavo, Michele
AU - Pawlyn, Charlotte
AU - Zweegman, Sonja
AU - Facon, Thierry
AU - Driessen, Christoph
AU - Hajek, Roman
AU - Dimopoulos, Melitios A
AU - Gay, Francesca
AU - Avet-Loiseau, Hervé
AU - Terpos, Evangelos
AU - Zojer, Niklas
AU - Mohty, Mohamad
AU - Mateos, Maria-Victoria
AU - Einsele, Hermann
AU - Delforge, Michel
AU - Caers, Jo
AU - Weisel, Katja
AU - Jackson, Graham
AU - Garderet, Laurent
AU - Engelhardt, Monika
AU - van de Donk, Niels
AU - Leleu, Xavier
AU - Goldschmidt, Hartmut
AU - Beksac, Meral
AU - Nijhof, Inger
AU - Abildgaard, Niels
AU - Bringhen, Sara
AU - Sonneveld, Pieter
PY - 2021/1
Y1 - 2021/1
N2 - Vaccination is one of the most successful medical interventions that has saved the life of millions of people. Vaccination is particularly important in patients with multiple myeloma, who have an increased risk of infections due to the disease-inherent immune suppression, and because of the immune suppressive effects of therapy. Hence, all appropriate measures should be exploited, to elicit an effective immune response to common pathogens like influenza, pneumococci, varicella zoster virus, and to those bacteria and viruses (haemophilus influenzae, meningococci, and hepatitis) that frequently may pose a significant risk to patients with multiple myeloma. Patients after autologous, and specifically after allogeneic transplantation have severely reduced antibody titers, and therefore require a broader spectrum of vaccinations. Response to vaccination in myeloma often is less vigorous than in the general population, mandating either measurement of the postvaccination antibody titers and/or repeating the vaccination. Here, we compile the existing data on vaccination in multiple myeloma and provide recommendations for clinical practice.
AB - Vaccination is one of the most successful medical interventions that has saved the life of millions of people. Vaccination is particularly important in patients with multiple myeloma, who have an increased risk of infections due to the disease-inherent immune suppression, and because of the immune suppressive effects of therapy. Hence, all appropriate measures should be exploited, to elicit an effective immune response to common pathogens like influenza, pneumococci, varicella zoster virus, and to those bacteria and viruses (haemophilus influenzae, meningococci, and hepatitis) that frequently may pose a significant risk to patients with multiple myeloma. Patients after autologous, and specifically after allogeneic transplantation have severely reduced antibody titers, and therefore require a broader spectrum of vaccinations. Response to vaccination in myeloma often is less vigorous than in the general population, mandating either measurement of the postvaccination antibody titers and/or repeating the vaccination. Here, we compile the existing data on vaccination in multiple myeloma and provide recommendations for clinical practice.
U2 - 10.1038/s41375-020-01016-0
DO - 10.1038/s41375-020-01016-0
M3 - SCORING: Review article
C2 - 32814840
VL - 35
SP - 31
EP - 44
JO - LEUKEMIA
JF - LEUKEMIA
SN - 0887-6924
IS - 1
ER -