Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) for the Treatment of Nonunion of the Femur in Children and Adolescents: A Retrospective Analysis
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Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) for the Treatment of Nonunion of the Femur in Children and Adolescents: A Retrospective Analysis. / Hissnauer, Tim N; Stiel, Norbert; Babin, Kornelia; Rupprecht, Martin; Ridderbusch, Karsten; Rueger, Johannes M; Stuecker, Ralf; Spiro, Alexander S.
In: BIOMED RES INT , Vol. 2017, 02.03.2017, p. 3046842.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) for the Treatment of Nonunion of the Femur in Children and Adolescents: A Retrospective Analysis
AU - Hissnauer, Tim N
AU - Stiel, Norbert
AU - Babin, Kornelia
AU - Rupprecht, Martin
AU - Ridderbusch, Karsten
AU - Rueger, Johannes M
AU - Stuecker, Ralf
AU - Spiro, Alexander S
PY - 2017/3/2
Y1 - 2017/3/2
N2 - Background. The aim of this study was to examine clinical and radiographic healing after rhBMP-2 application in children and adolescents presenting with nonunion of the femur and to investigate the safety of rhBMP-2 use in these cases. Materials and Methods. We reviewed the medical records of five patients with a mean age of 11 years (5.4 to 16.2) with nonunion of the femur who were treated with rhBMP-2 and internal fixation using a locking plate at a single institution. Particular attention was paid to identify all adverse events that may be due to rhBMP-2 use. Results. Union occurred in four of five patients at a mean of 12.1 months (7.9 to 18.9). The locking plates were removed after a mean of 16 months (11 to 23). One patient had nonunion due to deep infection. After a mean follow-up of 62.5 months (17 to 100), union was still evident in all four patients and they were fully weight-bearing without pain. Discussion. In this retrospective study, rhBMP-2 combined with a locking plate has been used successfully to treat children and adolescents with nonunion of the femur in four of five cases. One major complication was thought to be possibly related to its use.
AB - Background. The aim of this study was to examine clinical and radiographic healing after rhBMP-2 application in children and adolescents presenting with nonunion of the femur and to investigate the safety of rhBMP-2 use in these cases. Materials and Methods. We reviewed the medical records of five patients with a mean age of 11 years (5.4 to 16.2) with nonunion of the femur who were treated with rhBMP-2 and internal fixation using a locking plate at a single institution. Particular attention was paid to identify all adverse events that may be due to rhBMP-2 use. Results. Union occurred in four of five patients at a mean of 12.1 months (7.9 to 18.9). The locking plates were removed after a mean of 16 months (11 to 23). One patient had nonunion due to deep infection. After a mean follow-up of 62.5 months (17 to 100), union was still evident in all four patients and they were fully weight-bearing without pain. Discussion. In this retrospective study, rhBMP-2 combined with a locking plate has been used successfully to treat children and adolescents with nonunion of the femur in four of five cases. One major complication was thought to be possibly related to its use.
KW - Adolescent
KW - Bone Morphogenetic Protein 2
KW - Child
KW - Child, Preschool
KW - Drug-Related Side Effects and Adverse Reactions
KW - Female
KW - Femur
KW - Fracture Fixation, Internal
KW - Fractures, Bone
KW - Humans
KW - Male
KW - Recombinant Proteins
KW - Retrospective Studies
KW - Journal Article
U2 - 10.1155/2017/3046842
DO - 10.1155/2017/3046842
M3 - SCORING: Journal article
C2 - 28349058
VL - 2017
SP - 3046842
JO - BIOMED RES INT
JF - BIOMED RES INT
SN - 2314-6133
ER -
