Recipe for IBD: can we use food to control inflammatory bowel disease
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Recipe for IBD: can we use food to control inflammatory bowel disease. / Witkowski, Mario; Witkowski, Marco; Gagliani, Nicola; Huber, Samuel.
In: SEMIN IMMUNOPATHOL, Vol. 40, No. 2, 02.2018, p. 145-156.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Recipe for IBD: can we use food to control inflammatory bowel disease
AU - Witkowski, Mario
AU - Witkowski, Marco
AU - Gagliani, Nicola
AU - Huber, Samuel
PY - 2018/2
Y1 - 2018/2
N2 - The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the interaction of the intestinal mucosal immune system and the intestinal microbiota in the context of IBD. In addition, we discuss the impact of food components on immune responses in IBD. Finally, we address the current evidence of how this interaction (i.e., immune system-microbiota) can be modulated by food components, pre/probiotics, and fecal microbiota transplantation (FMT) and how these approaches can support intestinal homeostasis. By gathering the vast amount of literature available on the impact of food on IBD, we aim to distinguish between scientifically sound data and theories, which have not been included in this review.
AB - The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the interaction of the intestinal mucosal immune system and the intestinal microbiota in the context of IBD. In addition, we discuss the impact of food components on immune responses in IBD. Finally, we address the current evidence of how this interaction (i.e., immune system-microbiota) can be modulated by food components, pre/probiotics, and fecal microbiota transplantation (FMT) and how these approaches can support intestinal homeostasis. By gathering the vast amount of literature available on the impact of food on IBD, we aim to distinguish between scientifically sound data and theories, which have not been included in this review.
KW - Journal Article
KW - Review
U2 - 10.1007/s00281-017-0658-5
DO - 10.1007/s00281-017-0658-5
M3 - SCORING: Review article
C2 - 29124320
VL - 40
SP - 145
EP - 156
JO - SEMIN IMMUNOPATHOL
JF - SEMIN IMMUNOPATHOL
SN - 1863-2297
IS - 2
ER -