Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Standard
Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. / Koch-Gromus, Uwe; Narjes, Frank.
In: CURR TOP MED CHEM, Vol. 7, No. 13, 13, 2007, p. 1302-1329.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
AU - Koch-Gromus, Uwe
AU - Narjes, Frank
PY - 2007
Y1 - 2007
N2 - The global prevalence of hepatitis C virus (HCV) infection and the serious consequences associated with the chronic state of the disease have become a worldwide health problem. A combination therapy comprising Interferon-alpha and Ribavirin represents the current standard treatment for chronic HCV infection, although it has demonstrated limited success and causes serious side effects. Promising alternative approaches toward the control of HCV infection include the development of small molecule inhibitors of viral enzymes interfering with the essential steps in the life cycle of the virus. In this review we will focus on inhibitors of the HCV-encoded NS5B RNA-dependent RNA polymerase (NS5B RdRp) which is essential for viral replication and has been recognized as a prime target for therapeutic intervention.
AB - The global prevalence of hepatitis C virus (HCV) infection and the serious consequences associated with the chronic state of the disease have become a worldwide health problem. A combination therapy comprising Interferon-alpha and Ribavirin represents the current standard treatment for chronic HCV infection, although it has demonstrated limited success and causes serious side effects. Promising alternative approaches toward the control of HCV infection include the development of small molecule inhibitors of viral enzymes interfering with the essential steps in the life cycle of the virus. In this review we will focus on inhibitors of the HCV-encoded NS5B RNA-dependent RNA polymerase (NS5B RdRp) which is essential for viral replication and has been recognized as a prime target for therapeutic intervention.
M3 - SCORING: Zeitschriftenaufsatz
VL - 7
SP - 1302
EP - 1329
JO - CURR TOP MED CHEM
JF - CURR TOP MED CHEM
SN - 1568-0266
IS - 13
M1 - 13
ER -
