Recent insights into comorbidities in atopic dermatitis
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Recent insights into comorbidities in atopic dermatitis. / Gewiss, Caroline; Augustin, Matthias.
In: EXPERT REV CLIN IMMU, Vol. 19, No. 4, 04.2023, p. 393-404.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Recent insights into comorbidities in atopic dermatitis
AU - Gewiss, Caroline
AU - Augustin, Matthias
PY - 2023/4
Y1 - 2023/4
N2 - INTRODUCTION: The relationship between atopic dermatitis and atopic diseases such as food allergies, asthma, and allergic rhinitis in terms of co-occurrence, underlying mechanisms, and therapy is well documented. There is increasing evidence that atopic dermatitis is associated with non-atopic comorbidities such as cardiac, autoimmune, and neuropsychological comorbidities, as well as cutaneous and extracutaneous infections, establishing atopic dermatitis as a systemic disease.AREAS COVERED: The authors reviewed evidence on atopic and non-atopic comorbidities of atopic dermatitis. A literature search was conducted in PubMed for peer-reviewed articles published until October 2022.EXPERT OPINION: Atopic and non-atopic diseases coexist with atopic dermatitis more often than would be expected by chance. The effect of biologics and small molecules on atopic and non-atopic comorbidities may contribute to a better understanding of the relationship between atopic dermatitis and its comorbidities. Their relationship needs to be explored further to dismantle the underlying mechanism and move toward an atopic dermatitis endotype-based therapeutic approach.
AB - INTRODUCTION: The relationship between atopic dermatitis and atopic diseases such as food allergies, asthma, and allergic rhinitis in terms of co-occurrence, underlying mechanisms, and therapy is well documented. There is increasing evidence that atopic dermatitis is associated with non-atopic comorbidities such as cardiac, autoimmune, and neuropsychological comorbidities, as well as cutaneous and extracutaneous infections, establishing atopic dermatitis as a systemic disease.AREAS COVERED: The authors reviewed evidence on atopic and non-atopic comorbidities of atopic dermatitis. A literature search was conducted in PubMed for peer-reviewed articles published until October 2022.EXPERT OPINION: Atopic and non-atopic diseases coexist with atopic dermatitis more often than would be expected by chance. The effect of biologics and small molecules on atopic and non-atopic comorbidities may contribute to a better understanding of the relationship between atopic dermatitis and its comorbidities. Their relationship needs to be explored further to dismantle the underlying mechanism and move toward an atopic dermatitis endotype-based therapeutic approach.
KW - Humans
KW - Dermatitis, Atopic/epidemiology
KW - Comorbidity
KW - Asthma
KW - Rhinitis, Allergic/epidemiology
KW - Food Hypersensitivity
U2 - 10.1080/1744666X.2023.2181790
DO - 10.1080/1744666X.2023.2181790
M3 - SCORING: Review article
C2 - 36796057
VL - 19
SP - 393
EP - 404
JO - EXPERT REV CLIN IMMU
JF - EXPERT REV CLIN IMMU
SN - 1744-666X
IS - 4
ER -